54 results about "Cerebral embolus" patented technology

There is disclosed a porous emboli deflector for preventing cerebral emboli while maintaining cerebral blood flow during an endovascular or open surgical procedure. The device prevents the entrance of emboli of a size able to cause stroke (such as greater than 100 microns) from entering either the right or left common carotid arteries, and / or the right or left vertebral arteries by deflecting emboli downstream of these vessels. The device can be placed prior to any manipulation of the heart or aorta allowing maximal protection of the brain during the index procedure. The deflector has a low profile within the aorta which allows sheaths, catheters, or wires used in the index procedure to pass. Also disclosed are methods for insertion and removal of the deflector.

There is disclosed a porous emboli deflector for preventing cerebral emboli while maintaining cerebral blood flow during an endovascular or open surgical procedure. The device prevents the entrance of emboli of a size able to cause stroke (such as greater than 100 microns) from entering either the right or left common carotid arteries, and / or the right or left vertebral arteries by deflecting emboli downstream of these vessels. The device can be placed prior to any manipulation of the heart or aorta allowing maximal protection of the brain during the index procedure. The deflector has a low profile within the aorta which allows sheaths, catheters, or wires used in the index procedure to pass. Also disclosed are methods for insertion and removal of the deflector.

There is disclosed a porous emboli deflector for preventing cerebral emboli while maintaining cerebral blood flow during an endovascular or open surgical procedure. The device prevents the entrance of emboli of a size able to cause stroke (such as greater than 100 microns) from entering either the right or left common carotid arteries, and / or the right or left vertebral arteries by deflecting emboli downstream of these vessels. The device can be placed prior to any manipulation of the heart or aorta allowing maximal protection of the brain during the index procedure. The deflector has a low profile within the aorta which allows sheaths, catheters, or wires used in the index procedure to pass. The deflector shaft could have a first portion and a second portion, the second portion being more flexible than the first portion. The deflector frame can include one, two, or more movable structures, such as hinges. Also disclosed are methods for insertion and removal of the deflector.

There is disclosed a porous emboli deflector for preventing cerebral emboli while maintaining cerebral blood flow during an endovascular or open surgical procedure. The device prevents the entrance of emboli of a size able to cause stroke (such as greater than 100 microns) from entering either the right or left common carotid arteries, and / or the right or left vertebral arteries by deflecting emboli downstream of these vessels. The device can be placed prior to any manipulation of the heart or aorta allowing maximal protection of the brain during the index procedure. The deflector has a low profile within the aorta which allows sheaths, catheters, or wires used in the index procedure to pass. Also disclosed are methods for insertion and removal of the deflector.

There is disclosed a porous emboli deflector for preventing cerebral emboli while maintaining cerebral blood flow during an endovascular or open surgical procedure. The device prevents the entrance of emboli of a size able to cause stroke (greater than 100 microns in the preferred embodiment) from entering either the right or left carotid arteries by deflecting emboli downstream in the blood flow. The device can be placed prior to any manipulation of the heart or aorta allowing maximal protection of the brain during the index procedure. The device has a low profile within the aorta which allows sheaths, catheters, or wires used in the index procedure to pass. Also disclosed are methods for insertion and removal of the device.

There is disclosed a porous emboli deflector for preventing cerebral emboli while maintaining cerebral blood flow during an endovascular or open surgical procedure. The device prevents the entrance of emboli of a size able to cause stroke (such as greater than 100 microns) from entering either the right or left common carotid arteries, and / or the right or left vertebral arteries by deflecting emboli downstream of these vessels. The device can be placed prior to any manipulation of the heart or aorta allowing maximal protection of the brain during the index procedure. The deflector has a low profile within the aorta which allows sheaths, catheters, or wires used in the index procedure to pass. Also disclosed are methods for insertion and removal of the deflector.

The novel amidino derivatives of the formula (I):wherein all the symbols are as in specification defined;have an inhibitory activity of a blood coagulation factor VIIa and are useful for treatment and / or prevention of several angiopathy caused by enhancing a coagulation activity, such as disseminated intravascular coagulation, coronary thrombosis, cerebral infarction, cerebral embolism, transient ischemic attack, cerebrovascular disorders, pulmonary vascular diseases, deep venous thrombosis, peripheral arterial obstruction, thrombosis after artificial vascular transplantation and artificial valve transplantation, post-operative thrombosis, reobstruction and restenosis after coronary artery bypass operation, reobstruction and restenosis after PTCA or PTCR, thrombosis by extracorporeal circulation and procoagulative diseases such as glomerlonephriitis.

There is disclosed a porous emboli deflector for preventing cerebral emboli while maintaining cerebral blood flow during an endovascular or open surgical procedure. The device prevents the entrance of emboli of a size able to cause stroke (such as greater than 100 microns) from entering either the right or left common carotid arteries, and / or the right or left vertebral arteries by deflecting emboli downstream of these vessels. The device can be placed prior to any manipulation of the heart or aorta allowing maximal protection of the brain during the index procedure. The deflector has a low profile within the aorta which allows sheaths, catheters, or wires used in the index procedure to pass. Also disclosed are methods for insertion and removal of the deflector.

There is disclosed a porous emboli deflector for preventing cerebral emboli while maintaining cerebral blood flow during an endovascular or open surgical procedure. The device prevents the entrance of emboli of a size able to cause stroke (greater than 100 microns in the preferred embodiment) from entering either the right or left carotid arteries by deflecting emboli downstream in the blood flow. The device can be placed prior to any manipulation of the heart or aorta allowing maximal protection of the brain during the index procedure. The device has a low profile within the aorta which allows sheaths, catheters, or wires used in the index procedure to pass. Also disclosed are methods for insertion and removal of the device.

The invention belongs to the technical field of medicaments and provides active ingredients of Chinese herbal medicine camptosorus sibiricus and an extraction method and use of the same. The extraction method comprises a water extraction method, an alcohol extraction method, a macroporous resin purification method and a solvent extraction method. The main active ingredients of an extract obtained by the method are total flavonoids, total momordica saponins and total organic acids, wherein the content of the total flavonoids is 1 to 35 percent, the content of the total momordica saponins is 1 to 25 percent and the content of the total organic acids is 1 to 3 percent. The invention also provides a method for preparing the camptosorus sibiricus into a proper formulation directly or by mixing with solid or liquid commonly used for preparations of the type in pharmaceutics. The active ingredients of the camptosorus sibiricus and the preparation thereof have functions of treating thromboangiitis obliterans, nephritis, traumatism and bleeding, metrorrhagia, neurodermitis, hemiplegia caused by cerebral embolism and diabetes-related complications. The extraction method is simple, easy to implement and low in cost. And the extract obtained is free from toxic and side effects.

Drug compositions containing a substituted diamine compound represented by formula (1):Q1-Q2-r-N(R1)-Q3-N(R2)  (1)wherein Q3 represents the following groupwherein Q5 represents an alkylene group having 4 carbon atoms, R3 represents a hydrogen atom, and R4 represents a 3-6 membered heterocyclic group which may be substituted; are useful for preventing and / or treating cerebral infarction, cerebral embolism, myocardial infarction, angina pectoris, pulmonary infarction, pulmonary embolism, Buerger's disease, deep venous thrombosis, disseminated intravascular coagulation syndrome, thrombus formation after artificial valve or joint replacement, thrombus formation and reocclusion after angioplasty, systemic inflammatory response syndrome (SIRS), multiple organ dysfunction syndrome (MODS), thrombus formation during extracorporeal circulation, or blood clotting upon blood drawing.

The present invention belongs to the field of pharmaceutical technology and relates to transdermal Ligustrazine plaster and its preparation. It has Ligustrazine phosphate or Ligustrazine as active medicinal component and consists of medicine storing back, adhering layer, release controlling film, back lining layer and protective layer. It is superior to available Ligustrazine preparation forms inmedicine releasing are, transdermal rate and lasting release time, and has the features of determined curative effect, stable quality, high safety, etc. Animal experiments show that the plaster can retard the effect of ischemic to cerebral damage, inhibit thrombosis caused by tissue damage, prevent and treat cerebral embolism and maintain balanced medicine density in blood for 24 hr; and has light irritation to skin, no irritability and no toxic reaction.

The invention provides a traditional Chinese medicine compound used for treating cardiovascular and cerebrovascular diseases, which is made of the following components by weight ratios: 5-25 portions of red sage root, 5-25 portions of astragalus root, 5-25 portions of pseudostellaria root, 3-23 portions of polygala aureocauda dunn, 3-23 portions of shepherds purse, 1-6 portions of notoginseng, 3-23 portions of oldenlandia, 3-23 portions of eucommia bark, 3-23 portions of prepared rehmannia root, and 1-6 portions of prepared licorice. The components of the traditional Chinese medicine compound can produce synergetic effect, thus treating the cardiovascular and cerebrovascular diseases with high efficiency. Clinical control studies prove that the traditional Chinese medicine compound has the total effective rate of 96.9% on treating cerebral embolism and the total effective rate of 100% on treating hypertension. Also, the traditional Chinese medicine compound has the advantages of quick effect and good and lasting curative effect.

The invention discloses application of (E)-2-(3,5-dimethoxybenzylidene)-cyclopentanone in preparing a medicine for treating cerebrovascular diseases. The related research indicates that the compound has an obvious cranial nerve protection effect, obviously reduces the focal cerebral ischemia rat cerebral infarction volume and remarkably improves the neurologic symptom. The (E)-2-(3,5-dimethoxybenzylidene)-cyclopentanone is used for preventing or treating the diseases such as ischemic brain injury, cerebral hemorrhage, cerebral thrombosis, cerebral embolism, cerebral infarction, cerebral apoplexy, lacunar infarction, transient ischemic attack, cerebral arteriosclerosis, diabetic cerebrovascular complications and the like.

The invention discloses a medicinal composition for treating cardiovascular and cerebrovascular diseases, and a preparation method and application of the medicinal composition. The medicinal composition can prolong coagulation time, reduce cholesterol levels and contribute to reducing the formation rate of thrombus and atherosclerosis, can be used for treating cerebrovascular diseases such as cerebral ischemia, cerebral thrombosis, cerebral embolism and the like, and cardiovascular diseases such as coronary disease, hypertension, hyperlipaemia, atherosclerosis, myocardial ischemia, arrhythmia, heart failure, stenocardia, myocardial infarction and the like, particularly has good treatment effect when used for continued treatment on patients suffering the cardiovascular and cerebrovascular diseases after emergency treatment, and is a new choice for clinical medication.

The invention belongs to the technical field of medicine and discloses a pharmaceutical composition for treating cardiovascular and cerebrovascular diseases. The pharmaceutical composition is prepared by ginsenoside and carithamine as main ingredients and can be prepared into pharmaceutically or clinically acceptable dosage forms. The pharmaceutical composition has functions of expanding blood vessels of brain, reducing cerebral vascular resistance, increasing cerebral blood flow, obviously minimizing infarct area of brain tissues, obviously lightening behavior disorders caused by brain tissue necrosis, and the like, and can be used for preparing medicaments for treating diseases such as cerebral circulation insufficiency, cerebral thrombosis, cerebral embolism, brain blood vessels spasm, brain insufficiency, senile dementia, Parkinsonism, cerebral apoplexy, hypertension, hyperlipemia, arteriosclerosis, coronary heart disease, angina pectoris, miocardial infarction, etc.

The present invention discloses a preparation method of Chinese medicine preparation for treating ischemic cardiovascular and cerebrovascular diseases. The method comprises the following steps of: extracting and refining the ginkgo leaf and szechuan lovage rhizome to obtain the extract with higher content of active ingredient, adding the extract with pharmaceutic adjuvant with a ratio of 1 : 1 - 5 and 1 : 1 - 8, mixing uniformly, and preparing into soft capsule and pills respectively. The Chinese medicine preparation has significant effect on the treatment of ischemic cardiovascular and cerebrovascular diseases, coronary heart disease, angina pectoris, cerebral embolism, cerebral vasospasm and the like, no toxic and side-effect, the production technology is simple, and the quality control of product is convenient.

The invention discloses application of salvianolic acid A in preparation of a drug for treating cerebral hemorrhage. Cerebral hemorrhage comprises simple cerebral hemorrhage stroke, hemorrhage after cerebral embolism and hemorrhage caused by thrombolytic drug treatment and other factors. Experimental research finds that salvianolic acid A can significantly reduce the cerebral infarction volume andencephaledema of rats, improve neurological functions and protect blood-brain barrier damage caused by thrombolytic drugs such as t-PA, thereby reducing the risk and degree of hemorrhagic transformation when the thrombolytic drugs are used. The salvianolic acid A can be used for preparing the drug for treating cerebral hemorrhage and hemorrhage caused by thrombolytic drug treatment, relieving secondary hemorrhage in ischemic areas and improving prognosis of patients.

The present invention provides a kind of capsule for treating cardiac and cerebral vascular diseases. The capsule has effective component total arasaponin comprising ginsenoside Rg1 10.0-80.0%, ginsenoside Rb1 10.0-87.0% and arasaponin R1 2.0-75.0%. The preparation process includes the following steps: crushing axial root of notoginseng and soaking in ethanol; percolating in ethanol and regulating pH to 5.0-8.0 and stilling; filtering and decompression concentrating to recover ethanol; drying and crushing extractum; adding supplementary material and encapsulating. The capsule is used in treating cardiac and cerebral vascular diseases.

A medicine in the form of dispersing tablet for treating apoplexy, coronary heart disease, cerebral infarction, etc is proportionally prepared from tribulus saponin, cross-linked polyvinyl pyrrolidone, low-substituted hydroxypropyl cellulose and / or carboxymethyl cellulose sodium, carboxymethyl starch sodium, hydroxypropyl cellulose, microcrystalline cellulose, magnesium stearate, and micropowdered silica gel or SiO2.

The invention relates to applications of ozonized oil in prevention and treatment of ischemic cardiovascular and cerebrovascular diseases, chronic gastritis and type 2 diabetes as well as combined medication of medicines for treating the diseases. The invention particularly relates to applications of ozonized oil in prevention and treatment of coronary occlusion, angina pectoris, arrhythmia, premature beat, arrhythmia, cerebral infarction (including cerebral embolism and cerebral thrombosis), cerebral hemorrhage, cardiovascular and cerebrovascular atherosclerosis, chronic gastritis (including superficial gastritis, atrophic gastritis and erosive gastritis) and type 2 diabetes by virtue of an oral administration route.

The invention relates to the technical field of medical equipment, and discloses nursing equipment for assisting limb movement of a cerebral embolism patient. The nursing equipment comprises a frame body, a sliding platform is movably connected to the interior of the frame body, the front surface of the sliding platform is movably connected with a positioning platform, a driving mechanism is movably connected to the front face of the positioning platform, a limiting frame is movably connected to the left side of the driving mechanism, a connecting rod is movably connected into the limiting frame, a return spring is movably connected to the outer side of the connecting rod in a sleeving mode, and a self-locking mechanism is movably connected to the left side of the limiting frame. Accordingto the nursing equipment, through the advantages of constant advancing distance and self-locking, the strides of the patient are consistent all the time when the limb training movement is conducted,the muscle memory of the patient can be effectively improved, meanwhile, the patient can be prevented from falling down due to backward leaning through the self-locking design, and the use safety of the equipment is improved.

The invention discloses application of 5-(3', 5'-dimethoxybenzylidene)-2-sulfo-imidazole-4-one to preparation of drugs for treating cerebrovascular diseases. According to relevant researches disclosed by the invention, the compound has a remarkable cerebral nerve protection effect, can obviously reduce the volume of cerebral infarction of a focal cerebral ischemia rat and can obviously improve neurological signs; and moreover, the protection effect of an IV4 compound to cerebral ischemic injuries is related to the inhibition of the activation of lysosomal enzyme cathepsin B, so that the compound can be used for preparing drugs for preventing or treating diseases such as ischemic brain injuries, cerebral hemorrhage, cerebral thrombosis, cerebral embolism, cerebral infarction, cerebral stroke, lacunar infarction, transient ischemia attacks, cerebral arteriosclerosis and diabetic cardiovascular complications.

The invention relates to an acanthopanax root, schisandra chinensis and xylitol healthy beverage and a preparation method thereof. The preparation method specifically comprises a formula, a preparation method and an application thereof. The formula and the preparation method are designed for developing health management and service in cooperation, facilitating application and ensuring the safety and health-care function of the composition; aiming at consumption groups of middle-aged and elderly patients suffering from coronary heart disease, cerebral embolism, cerebral hemorrhage, hypertension, diabetes mellitus complicated with double heart disease (cardiac neurosis), the beverage has the health-care functions of improving sleep and glycometabolism, reducing clinical risk factors, reducing drug dosage and the like. A health management and health service technical scheme is added, the health service capability of traditional Chinese medicine is improved, the construction of a complete large health industry chain and healthy beverage industry specifications is accelerated, and the industrialization, standardization, health and internationalization development of medicinal and edible substances is promoted.

The invention discloses a traditional Chinese medicine formula for treating cerebrovascular disease and a preparation method. The traditional Chinese medicine formula contains 4.7-10.3 parts of astragalus membranaceus, 3.7-5.3 parts of pseudo-ginseng, 17.3-21.8 parts of polished round-grained rice, and 0.17-0.21 part of pericarpium citri reticulatae powder. The preparation method comprises the following steps: firstly, decocting 4.7-10.3 parts of astragalus membranaceus and 3.7-5.3 parts of pseudo-ginseng herba with water; then deslagging the decoction thick juice, and adding 17.3-21.8 parts of polished round-grained rice for boiling; and finally, when the polished round-grained rice is thoroughly cooked, adding 0.17-0.21 part of pericarpium citri reticulatae powder, and boiling for a moment. The invention has the following advantages: the formula is low in cost, the preparation process is simple and feasible, and the formula has a remarkable treatment and prevention effect for cerebral embolism, and can delay transformation of cerebral ischemia patient to cerebral infarction disease, promote platelet aggregation and deformation and release substances such as ADP, platelet factor III and calcium ions, so as to achieve a hemostasis effect. The traditional Chinese medicine formula can obviously reduce cerebral infarction area and has a remarkable efficacy for treating cerebral infaction.

The invention provides a pharmaceutical composition. The pharmaceutical composition is prepared from aspirin, atorvastatin, valsartan, hydrochlorothiazide, folic acid substances and pharmaceutically acceptable auxiliary materials. The pharmaceutical composition provided by the invention has the advantages that the pharmaceutical composition provided by the invention has a multi-target synergistic prevention effect on vascular diseases, especially cerebral embolism, that is, the composition not only can reduce blood pressure, blood fat and blood homocysteine level, but also has an effect of preventing thrombosis, and reduces the risk of cerebral apoplexy. In addition, the form of the pharmaceutical composition is beneficial to improving the medication compliance of patients.

The utility model relates to the technical field of cerebral embolism models, in particular to a suppository for cerebral embolism experiments, which comprises a catheter. The two sets of steering mechanisms are movably installed in the guide pipe and used for adjusting the orientation of the end of the guide pipe. The moving structure is movably mounted in the middle of the interior of the catheter, and the moving structure is used for blocking a blood vessel with the embolism; and the injection molding assembly is movably mounted at the upper end of the outer wall of the catheter and is used for filling the embolism. The utility model discloses. A corrugated pipe is installed on the lower side of the outer wall of the fixing block, so that the fixing block has certain rotating capacity, rotation is controlled through a first connecting line and a second connecting line which are fixedly connected to the lower side of the outer wall of the fixing block, two caps connected to the outer wall of the fixing block in a sleeving mode are matched with each other, and a user can manufacture blockages by means of wax blocks by himself / herself, so that the use cost is reduced; and through the cooperation of the guide pipe and the push rod, the wire bolt can be quickly moved to a target position to release the blocking object.

The invention discloses a medicine composition for treating cerebrovascular and cardiovascular diseases as well as a preparation method and an application of the medicine composition. The medicine composition can resist thrombosis and blood stasis and can be used treating cerebrovascular diseases such as cerebral ischemia, cerebral thrombosis, cerebral embolism and the like and cardiovascular diseases such as coronary heart disease, hypertension, hyperlipidemia, atherosclerosis, atherosclerosis, arrhythmia, heat failure, angina, myocardial infarction and the like. The medicine composition is especially used for continuously treating patients with cerebrovascular and cardiovascular diseases after emergency treatment and has good curative effects, and a new choice is provided for clinical medication.