Medical applications and administration route for ozonized oil

A technology of ozonated oil and drug delivery route, which is applied in the direction of medical preparations containing active ingredients, pharmaceutical formulas, digestive system, etc., and can solve the problems of unclear specific mechanism, long course of treatment, difficulty in ensuring the effective concentration of gas entering the body, etc.

Inactive Publication Date: 2017-01-25
侯建生
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The function of ozone gas may be realized through the following three ways: (1), ozone generates substances similar to active oxygen through biochemical reactions in the body (hydroxyl radical OH - , superoxide anion O 2 - etc.), extensively affects the redox system of the body; (2), ozone can cause the aggregation of endothelial progenitor cells and promote the generation of nitric oxide (NO), which can relax blood vessels; (3), ozone can induce bone marrow stem cells to At the site of vascular injury, it promotes the repair and reconstruction of damaged blood vessels, but the specific mechanism is still unclear
[0003] There are many defects in the above route of administration: in the process of entering the body, it has been in contact with too many substances, and it is difficult to ensure the effective concentration of the gas entering the body
If given too much, it is very easy to induce discomfort in the body, and the operation process is cumbersome, coupled with the long course of treatment, it is difficult for patients to accept

Method used

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  • Medical applications and administration route for ozonized oil
  • Medical applications and administration route for ozonized oil
  • Medical applications and administration route for ozonized oil

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Example 1 Preparation of ozonated olive oil enteric-coated capsules

[0037] 1. Preparation of ozone gas. The invention adopts medical oxygen to prepare ozone gas through an ozone generator.

[0038] It is selected from the DRO3-A ozone machine (power≦55W) designed and produced by Xi'an Derun Biotechnology Co., Ltd.

[0039] 2. The whole process of preparing ozonated oil and ozonated oil enteric-coated capsules must be carried out at 20-25°C to ensure that the ozonated oil does not undergo pyrolysis.

[0040] 3. Put 3kg of olive oil into the reactor; 3 / h flow rate was added, and the total reaction time was 20 hours. After the reaction is over, the residual gas is inactivated.

[0041] 4. The obtained ozonated olive oil has a concentration of 40 mg / L and can be stored stably for ten months at 25°C.

[0042] 5. Preparation of ozonated olive oil enteric-coated capsules.

[0043] (1) Preparation of capsule material: Weigh water, gelatin, glycerin and glutinous rice f...

Embodiment 2

[0046] Embodiment 2 Preparation of enteric-coated capsules of ozonized ozonated olive oil, soybean oil and peanut oil mixed oil

[0047] 1. Preparation of ozone gas. The invention adopts medical oxygen to prepare ozone gas through an ozone generator.

[0048] It is selected from the DRO3-A ozone machine (power≦55W) designed and produced by Xi'an Derun Biotechnology Co., Ltd.

[0049] 2. The whole process of preparing ozonated oil and ozonated oil enteric-coated capsules must be carried out at 20-25°C to ensure that the ozonated oil does not undergo pyrolysis.

[0050] 3. Put 1kg of olive oil, 1kg of soybean oil and 1kg of peanut oil into the reaction kettle; 3 / h flow rate was added, and the total reaction time was 20 hours. After the reaction is over, the residual gas is inactivated.

[0051] 4. The concentration of the obtained ozonated mixed oil is 40mg / L, and it can be stored stably for ten months at 25°C.

[0052] 5. Preparation of ozonated mixed oil enteric-coated c...

Embodiment 3

[0056] Example 3 Preparation of ozonated olive oil enteric-coated capsules containing surfactant

[0057] 1. Preparation of ozone gas. The invention adopts medical oxygen to prepare ozone gas through an ozone generator.

[0058] It is selected from the DRO3-A ozone machine (power≦55W) designed and produced by Xi'an Derun Biotechnology Co., Ltd.

[0059] 2. The whole process of preparing ozonated oil and ozonated oil enteric-coated capsules must be carried out at 20-25°C to ensure that the ozonated oil does not undergo pyrolysis.

[0060] 3. Put 3kg of olive oil into the reaction kettle, slowly add 20mL of sorbitan monooleate polyoxyethylene ether (Tween 80), mix well, and use ozone at 150m 3 / h flow rate was added, and the total reaction time was 20 hours. After the reaction is over, the residual gas is inactivated.

[0061] 4. The obtained ozonated olive oil has a concentration of 40 mg / L and can be stored stably for ten months at 25°C.

[0062] 5. Preparation of ozonate...

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PUM

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Abstract

The invention relates to applications of ozonized oil in prevention and treatment of ischemic cardiovascular and cerebrovascular diseases, chronic gastritis and type 2 diabetes as well as combined medication of medicines for treating the diseases. The invention particularly relates to applications of ozonized oil in prevention and treatment of coronary occlusion, angina pectoris, arrhythmia, premature beat, arrhythmia, cerebral infarction (including cerebral embolism and cerebral thrombosis), cerebral hemorrhage, cardiovascular and cerebrovascular atherosclerosis, chronic gastritis (including superficial gastritis, atrophic gastritis and erosive gastritis) and type 2 diabetes by virtue of an oral administration route.

Description

technical field [0001] The present invention relates to the medical function of ozonized oil and its administration route. It specifically relates to the treatment of ischemic cardiovascular and cerebrovascular diseases (including myocardial infarction, angina pectoris, arrhythmia, premature beat, arrhythmia, cerebral infarction (including cerebral embolism and cerebral thrombosis), cerebral hemorrhage) by taking ozonated oil orally in the form of capsules. and cardiovascular and cerebral atherosclerosis, etc.), chronic gastritis (including superficial gastritis, atrophic gastritis and erosive gastritis) and type Ⅱ diabetes mellitus. Background technique [0002] Velio Bocci in the book "Ozone Therapy" outlines the use of low doses of ozone gas to perform many beneficial functions without side effects, namely ozone therapy (see "Oxygen-Ozone Therapy" by Velio Bocci, Peking University Medical Press , 2004). Ozone therapy can be achieved through a variety of routes of admini...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/00A61K9/66A61K47/44A61P1/04A61P3/10A61P9/10A61P9/06A61P7/02
CPCA61K33/00A61K9/0019A61K9/0053A61K9/4808A61K9/4816A61K9/4858A61K47/44
Inventor 李新平侯建生
Owner 侯建生
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