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Callicarpa nudiflora Hook. et Arn. extract, preparation method and application of callicarpa nudiflora Hook. et Arn. Extract for resisting cervicitis

A technology of Auranthus nudiflora and its extract, which is applied in the field of preparation of Aurantia nudiflora extract, to achieve the effect of reducing TNF-α, the preparation method is simple and easy, and the effect of strong anti-cervicitis activity

Inactive Publication Date: 2020-01-24
HUANGHE S & T COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although Zizhu nudiflora is effective as a compound drug, there is no research about its single drug in the treatment of cervicitis. Therefore, the present invention takes Zizhu nudiflora as the research object to study its anti-inflammation, hemostasis and its effect on phenol-induced cervical cancer. The role of the rat model of cervicitis, revealing the mechanism of the anti-cervicitis of the nudibranch

Method used

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  • Callicarpa nudiflora Hook. et Arn. extract, preparation method and application of callicarpa nudiflora Hook. et Arn. Extract for resisting cervicitis
  • Callicarpa nudiflora Hook. et Arn. extract, preparation method and application of callicarpa nudiflora Hook. et Arn. Extract for resisting cervicitis
  • Callicarpa nudiflora Hook. et Arn. extract, preparation method and application of callicarpa nudiflora Hook. et Arn. Extract for resisting cervicitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Embodiment 1: the preparation method of nudibranch purple pearl extract:

[0044] (1) Take the leaves of Auranthus nudiflora and grind them, then add them to the faucet bottle, add 90% ethanol solution for the first time, soak for 24 hours, collect the extract and configure 3000mL of 90% ethanol at the same time, start washing (the liquid level should not be low in dregs).

[0045] (2) Take the powder of Auranthus nudiflora leaves, prepare a 90% ethanol solution for the first time and soak for 24 hours, add 8000mL of 90% ethanol successively after washing, and obtain Aurantia radiata extract A.

[0046] (3) Evaporate the extract A of A. nudiflora by rotary evaporation to obtain an extract-like object B.

[0047] (4) Add ultrapure water to the extract-like object B, and obtain a dispersion liquid by ultrasonic vibration, divide the dispersion liquid into two parts of equal volume, each part is sequentially extracted with petroleum ether, ethyl acetate, and n-butanol , ...

Embodiment 2

[0048] Embodiment 2: the preparation method of nudibranch extract:

[0049] (1) Take 1081g of Auranthus nudiflora leaves and crush them, then add them to the faucet bottle, add 4000mL of ethanol solution with a mass fraction of 90% for the first time, soak for 24h, collect the extract and prepare 2500mL of ethanol solution with a mass fraction of 90% , start washing (requires that the liquid level should not be lower than the dregs).

[0050] (2) Take 1000g of Auranthus nudiflora leaf powder, prepare 4000ml of ethanol solution with a mass fraction of 90% for the first time, soak for 24h, add 7000ml of 90% ethanol successively after washing, and obtain Aurora nudeflora extract A.

[0051] (3) Concentrating the extract A of Aurantia nudica at 40-45°C with a rotary evaporator to obtain an extract-like object B.

[0052] (4) Add ultrapure water to the extract-like object B, and obtain a dispersion liquid by ultrasonic vibration, divide the dispersion liquid into two parts of equa...

Embodiment 3

[0053] Embodiment 3: the preparation method of nudibranch extract:

[0054] (1) Take 1081g of Auranthus nudiflora leaves and crush them, then add them to the faucet bottle, add 6000mL of ethanol solution with a mass fraction of 90% for the first time, soak for 24h, collect the extract and prepare 3500mL of ethanol solution with a mass fraction of 90% , start washing (requires that the liquid level should not be lower than the dregs).

[0055] (2) Take 1000g of Auranthus nudiflora leaf powder, prepare 6000ml of ethanol solution with a mass fraction of 90% for the first time, soak for 24h, add 9000ml of 90% ethanol successively after washing, and obtain Aurora nudiflora extract A.

[0056] (3) Concentrating the extract A of Aurantia nudica at 40-45°C with a rotary evaporator to obtain an extract-like object B.

[0057] (4) Add ultrapure water to the extract-like object B, and obtain a dispersion liquid by ultrasonic vibration, divide the dispersion liquid into two parts of equal ...

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Abstract

The invention relates to the field of extraction of traditional Chinese medicines, in particular to a callicarpa nudiflora Hook. et Arn. extract, preparation method and application of the callicarpa nudiflora Hook. et Arn. extract for resisting cervicitis. The callicarpa nudiflora Hook. et Arn. extract is a callicarpa nudiflora Hook. et Arn. n-butanol extract; the preparation method of the callicarpa nudiflora Hook. et Arn. extract is simple, feasible, and low in cost; and the callicarpa nudiflora Hook. et Arn. extract is higher in cervicitis-resistant activity, and can obviously repair lesiontissues of the cervicitis.

Description

technical field [0001] The invention relates to the field of extraction of traditional Chinese medicines, in particular to a preparation method of an extract of Auranthus nudiflora and its anti-cervicitis application. Background technique [0002] The survey of Chinese women by the World Health Organization shows that about 41% of women of childbearing age in my country suffer from gynecological inflammatory diseases to varying degrees, and the incidence rate of married women is as high as 70%. According to statistics, cervicitis accounts for about 40-50% of the total number of obstetrics and gynecology outpatients, ranking first among gynecological diseases, and chronic cervicitis accounts for 10% to 25% of outpatients. urgent demands of patients. [0003] Nudihua Zizhu is the dry leaf of the Verbenaceae Zizhu plant. This genus comes from the Verbenaceae. The "Dictionary of Chinese Medicine" records that Zizhu is Duhonghua and Huazizhu, which have the functions of detoxifi...

Claims

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Application Information

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IPC IPC(8): A61K36/85A61P15/00A61P29/00A61K127/00
CPCA61K36/85A61K2236/333A61K2236/39A61K2236/51A61K2236/53A61P15/00A61P29/00
Inventor 杨娟尚曙玉贾安
Owner HUANGHE S & T COLLEGE
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