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Preparation method of ultrathin cavity composite microfiber material based on microfluidic technology

A microfluidic technology and microfiber technology, which is applied in the field of preparation of ultra-thin cavity composite microfiber materials, can solve problems such as difficult to achieve large-scale preparation and limit the mixing of large flow rates, and achieve novel material structure and preparation The method is simple and the effect of great application value

Inactive Publication Date: 2020-01-24
DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The process of preparing fibers based on the interfacial complexation method of polyelectrolytes with opposite charges is relatively mild and can be prepared in aqueous solution at room temperature, but it is difficult to achieve large-scale preparation.
Mainly because in order to form a stable contact interface of two polyelectrolytes with different charges, the flow rate must be controlled in advection, which limits the mixing of large flows and the subsequent preparation of
In addition, the diameter of the fiber is approximately close to that of a cell, so it is challenging to prepare smooth fibers loaded with cells.
This limits this method to only a small range of research in the laboratory

Method used

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  • Preparation method of ultrathin cavity composite microfiber material based on microfluidic technology
  • Preparation method of ultrathin cavity composite microfiber material based on microfluidic technology
  • Preparation method of ultrathin cavity composite microfiber material based on microfluidic technology

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Experimental program
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Effect test

Embodiment 1

[0051] Sodium alginate with a mass volume concentration of 1% g / ml is used as the sample fluid in advance; methyl cellulose with a mass volume concentration of 2% g / ml is used as an inert fluid; acetic acid with a volume percentage of 1.5% is prepared with a mass volume concentration of 3% g / ml chitosan solution as a modification fluid, or chitosan and methylcellulose are mixed to obtain methylcellulose solutions containing different chitosan concentrations as a modification fluid; mass volume concentration 0.5% g / mlCaCl 2 as a sheath fluid;

[0052] Using a microfluidic chip, using figure 1 The microfluidic chip shown, with an air pump to control the CaCl 2 The Harvard pump is used to control the fluid flow rate of the other three channels, and the inert fluid is methylcellulose, the modified fluid is chitosan or the mixture of chitosan and methylcellulose, and the sample fluid is alginic acid. Sodium and sheath fluid CaCl 2 ;The flow rates of the first three are 0.4μl / min...

Embodiment 2

[0055] Sodium alginate with a mass volume concentration of 2% g / ml is used as the sample fluid in advance; methyl cellulose with a mass volume concentration of 3% g / ml is used as an inert fluid; ml of chitosan solution as a modification fluid, or mix chitosan and methylcellulose to obtain methylcellulose solutions containing different chitosan concentrations as a modification fluid; mass volume concentration 1% g / ml CaCl 2 as a sheath fluid;

[0056] A microfluidic chip is used to control CaCl with an air pump 2 The flow rate of the fluid in the other three channels is controlled by Harvard pump, and the inert fluid containing cells, i.e. methylcellulose, the modified fluid, i.e. chitosan or the mixture of chitosan and methylcellulose, and the sample are successively introduced into the chip. Fluid sodium alginate and sheath fluid CaCl 2 ;The flow rates of the first three are 0.8μl / min, 0.2μl / min, and 10μl / min respectively; the pressure of the pneumatic pump of the sheath fl...

Embodiment 3

[0059] Sodium alginate with a mass volume concentration of 5% g / ml is used as the sample fluid in advance; methyl cellulose with a mass volume concentration of 2% g / ml is used as an inert fluid; The chitosan solution of ml is used as the modified fluid, or chitosan and methylcellulose are mixed to obtain methylcellulose solutions containing different chitosan concentrations as the modified fluid; CaCl with a mass volume concentration of 2% g / ml 2 as a sheath fluid;

[0060] A microfluidic chip is used to control CaCl with an air pump 2 The flow rate of the fluid in the other three channels is controlled by Harvard pump, and the inert fluid containing cells, i.e. methylcellulose, the modified fluid, i.e. chitosan or the mixture of chitosan and methylcellulose, and the sample are successively introduced into the chip. Fluid sodium alginate and sheath fluid CaCl 2 ;The flow rates of the first three are 1.5μl / min, 0.3μl / min, and 20μl / min respectively; the pressure of the pneumat...

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Abstract

The invention provides a preparation method of an ultrathin cavity composite microfiber material based on a microfluidic technology. In the process of preparing common cavity microfibers, a modification material capable of being combined with a microfiber material on the outer layer is introduced into the cavity of the microfibers, the modification material is attached to the cavity while the cavity is formed to form a modification coating, and then an outer layer material is dissolved to obtain the ultrathin microfiber material. A micro-scale channel capable of generating a coaxial laminar flow pattern can be formed by utilizing a micro-fluidic chip technology, so that flow pattern control of sample fluid is realized, the sample fluid is finally solidified into a micro-scale cavity fibermaterial with a specific inner coating structure, and the ultra-thin cavity composite micro-fiber material is obtained by removing the outer layer material. The microfiber material can simulate microstructures in human tissues, and a new method and idea are provided for tissue engineering and organ regeneration.

Description

technical field [0001] The invention relates to a preparation method of an ultrathin cavity composite microfiber material, and in particular provides a preparation method of an ultrathin cavity composite microfiber material based on microfluidic technology. Background technique [0002] The interfacial complexation method is to self-assemble two polyelectrolytes with opposite charges into a macromolecular complex through electrostatic force. Microcapsules, thin films, multilayer films, etc. can be prepared by this method. Yamamoto and his colleagues proposed for the first time the formation of fibers by combining two oppositely charged polyelectrolytes at interfacial contacts through electrostatic forces. In this process, they carefully added the gellan gum aqueous solution to the chitosan aqueous solution dropwise, and at 50°C without stirring, a complex film was formed at the interface between the two, and after drying, a complex film was formed. fiber. ACA.Wan took thi...

Claims

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Application Information

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IPC IPC(8): D01F8/18D01F8/02D01F1/08B01L3/00
CPCB01L3/502707B01L2300/12D01F1/08D01F8/02D01F8/18
Inventor 秦建华刘慧于跃
Owner DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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