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A kind of coating technology of naltrexone implant and its application

A technology for implants and naltrexone, which is applied to the drug coating process and its application fields, can solve problems such as affecting the integrity of the drug, adhesion and rupture on the surface of the coating, and achieve the effect of avoiding the problem of incomplete coating.

Active Publication Date: 2021-02-23
SHENZHEN SCIENCARE MEDICAL INDUSTRIES CO. LTD.
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, as mentioned above, due to the excessive viscosity of polylactic acid, the contact between the coated microspheres or tablets and the bottom surface of the tray when placed on the tray when they are dry will cause adhesion and rupture of the coated surface, affecting the integrity of the drug.

Method used

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  • A kind of coating technology of naltrexone implant and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Embodiment 1 naltrexone implant coating process

[0041] as attached figure 1 As shown, the coating process of naltrexone implants is specifically:

[0042] (1) Polylactic acid with a molecular weight of 60,000 is dissolved in methylene chloride to form a coating solution with a concentration of 6%, which is placed in the coating pool 1 for subsequent use;

[0043] (2) Push the naltrexone implant 3 into the liquid pool pipe 2 with evenly distributed small holes arranged inside the coated pool 1, and move the implant 3 from one end of the liquid pool pipe 2 to the other end by external force for encapsulation. film, the coating time is 30s, and the temperature is 37°C.

[0044] (3) The naltrexone implant 3 was transferred to the air-drying device 4, air-dried at 20° C. for 30 seconds, and then vacuum-dried at 40° C. for 48 hours.

[0045] Wherein, the aperture density of liquid pool pipeline 2 is 150 / 30cm tube length, and the pipeline diameter of liquid pool pipeline ...

Embodiment 2

[0047] Embodiment 2 naltrexone implant coating process

[0048] as attached figure 1 Shown, the coating process of naltrexone implant is:

[0049] (1) Polylactic acid with a molecular weight of 50,000 is dissolved in methylene chloride to form a coating solution with a concentration of 5%, which is placed in the coating pool 1 for subsequent use;

[0050] (2) Push the naltrexone implant 3 into the liquid pool pipe 2 with evenly distributed small holes arranged inside the coated pool 1, and move the implant 3 from one end of the liquid pool pipe 2 to the other end by external force for encapsulation. film, the coating time is 50s, and the temperature is 33°C.

[0051] (3) The naltrexone implant was transferred to the air-drying device 4, air-dried at 24° C. for 15 seconds, and then vacuum-dried at 30° C. for 50 hours.

[0052] Wherein, the small hole density of the liquid pool pipeline 2 is 100 / 30cm tube length, the diameter of the inlet of the liquid pool pipeline 2 is 0.5 mm...

Embodiment 3

[0054] Embodiment 3 naltrexone implant coating process

[0055] as attached figure 1 Shown, the coating process of naltrexone implant is:

[0056] (1) Polylactic acid with a molecular weight of 70,000 is dissolved in ethyl acetate to form a coating solution with a concentration of 7%, which is placed in the coating pool 1 for subsequent use;

[0057] (2) Push the naltrexone implant 3 into the liquid pool pipe 2 with evenly distributed small holes arranged inside the coated pool 1, and move the implant 3 from one end of the liquid pool pipe 2 to the other end by external force for encapsulation. film, the coating time is 15s, and the temperature is 40°C.

[0058] (3) The naltrexone implant 3 was transferred to the air-drying device 4, air-dried at 18° C. for 45 minutes, and then vacuum-dried at 50° C. for 50 hours.

[0059] Wherein, the aperture density of liquid pool pipeline 2 is 200 / 30cm pipe length, and the pipeline diameter of liquid pool pipeline 2 entrance and the pip...

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Abstract

The invention belongs to the field of pharmaceutical coating technology, and specifically provides a coating technology for naltrexone implants, comprising the following steps: (1) dissolving polylactic acid in an organic solvent to form a coating solution, and placing it in a coating pool , standby; (2) Soak the naltrexone implant in the coating solution, wrap a layer of polylactic acid film on the surface of the implant; (3) hang and dry the naltrexone implant wrapped with the polylactic acid film . The coating pool is equipped with a liquid pool pipeline, which is evenly distributed with small holes and soaked in the coating liquid, so that the tablets can be evenly wrapped when passing through the liquid pool pipeline, and the method of hanging and drying is adopted to avoid the high viscosity. The coating fluid compromises the integrity of the coating due to the tablets sticking to each other or coming into contact with other objects. The present invention also provides the application of the above coating process in the preparation of naltrexone implants.

Description

technical field [0001] The invention relates to a drug coating process and its application, in particular to a naltrexone implant coating process and its application. Background technique [0002] The abuse of heroin and other drugs and alcohol is a global public hazard. In recent years, it has re-spread in our country and has an increasing trend year by year. For the detoxification treatment of addicts, no matter what method is given, the relapse rate is as high as 90-95%. In order to reduce the relapse rate, two measures with completely opposite pharmacological effects are commonly used in the world at present: one is to maintain treatment with opioid receptor agonists such as methadone and LAAM; the other is to use opioid receptor antagonists such as Naltrexone. The former is essentially a palliative measure aimed at substitution, while the latter program embodies the active efforts of biomedical methods to prevent relapse. [0003] Naltrexone, whose chemical name is 1...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/32A61K47/34A61K31/485A61P25/36
CPCA61K9/0024A61K9/2853A61K9/2893A61K31/485A61P25/36
Inventor 尹述贵王实强贾少微张涛刘庆哲
Owner SHENZHEN SCIENCARE MEDICAL INDUSTRIES CO. LTD.
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