The invention relates to a preparation method of a hydroxyapatite /
drug-loaded
hydrogel composite coating on the surface of micro-arc
titanium oxide. The preparation method comprises the following steps of: soaking a
titanium sample subjected to micro-arc oxidation treatment in an alkaline solution, and carrying out
hydrothermal treatment to form a hydroxyapatite
bioactive coating on the surface of micro-arc
titanium oxide; putting an aluminum template into a culture dish, then adding a mixture of a
prepolymer of PDMS and a curing agent, and curing to obtain a PDMS template; and mixing a
chitosan aqueous solution and a
sodium alginate
aqueous solution, adding a
drug to obtain a
drug-loaded hydrogel solution, adding a
photoinitiator to the drug-loaded hydrogel solution, dropwise adding to the template, placing a sample on the PDMS template, curing under
ultraviolet light, and carrying out
freeze drying. According to the method, a
composite coating with a porous structure and a
nanorod shape is generated through micro-arc oxidation and
hydrothermal treatment, and the
bonding strength and the
biological activity of the
implant and bones are improved. The drug-loaded composite hydrogel is loaded on the surface of the micro-arc
titanium oxide through the PDMS template, so that the
implant coating is endowed with more biological functions.