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Medical antibacterial coating layer and preparation method thereof

A coating and performance technology, applied in the field of medical antibacterial coating materials and their preparation, can solve the problems of increasing the preparation cost, wasting scarce resources, etc., and achieves the effect of saving resources, efficient antibacterial effect, and compact structure

Inactive Publication Date: 2018-03-06
NANJING UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In order to improve the antibacterial effect, most of the current research directions are to increase the amount of antibacterial sources to obtain high antibacterial properties, which not only increases the cost of preparation, but also wastes precious and scarce resources on the earth.

Method used

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  • Medical antibacterial coating layer and preparation method thereof
  • Medical antibacterial coating layer and preparation method thereof
  • Medical antibacterial coating layer and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Present embodiment is a kind of preparation method of HA coating, comprises the following steps:

[0025] The first step: chemically clean the surface of quartz, aluminum alloy, and single crystal silicon wafers to remove grease and other pollutants on the surface. Washing with water; ultrasonic cleaning in acetone solution, ethanol solution and deionized water to improve the surface activity of the substrate, thereby enhancing the bonding force between the film and the substrate material; after cleaning, place the substrate in an oven to dry and store.

[0026] Step 2: Take 7.5g of HA powder and press it into a target with a diameter of 30mm and a target thickness of 5mm with a tablet press;

[0027] Step 3: Place the above target in the target position of the pulsed laser deposition vacuum chamber, and place the above substrate in the substrate position of the vacuum chamber;

[0028] Step 4: Start the pulse laser instrument and adjust the pulse laser intensity to 50...

Embodiment 2

[0032] Present embodiment is a kind of preparation method of HA-silver nitrate nanocomposite coating, comprises the following steps:

[0033] The first step: chemically clean the surface of quartz, aluminum alloy, and single crystal silicon wafers to remove grease and other pollutants on the surface. Washing with water; ultrasonic cleaning in acetone solution, ethanol solution and deionized water to improve the surface activity of the substrate, thereby enhancing the bonding force between the film and the substrate material; after cleaning, place the substrate in an oven to dry and store.

[0034] Step 2: Take 6g of HA and 1.5g of silver nitrate powder and grind them mechanically, mix them evenly according to the mass ratio of 4:1, and press them into a target with a diameter of 30mm and a target thickness of 5mm with a tablet press;

[0035] Step 3: Place the above target in the target position of the pulsed laser deposition vacuum chamber, and place the above substrate in th...

Embodiment 3

[0040] Present embodiment is a kind of preparation method of HA and norfloxacin active antibacterial coating, comprises the steps:

[0041] The first step: chemically clean the surface of quartz, aluminum alloy, and single crystal silicon wafers to remove grease and other pollutants on the surface. Washing with water; ultrasonic cleaning in acetone solution, ethanol solution and deionized water to improve the surface activity of the substrate, thereby enhancing the bonding force between the film and the substrate material; after cleaning, place the substrate in an oven to dry and store.

[0042] The second step: take 6g HA and 1.5g norfloxacin according to the mass ratio of 4:1, mechanically grind and mix them evenly, and press them into a target with a diameter of 30mm and a target thickness of 5mm with a tablet press;

[0043] Step 3: Place the above target in the target position of the pulsed laser deposition vacuum chamber, and place the above substrate in the substrate po...

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Abstract

The invention discloses a medical antibacterial coating layer and a preparation method thereof, and belongs to the technical field of medical antibacterial materials. A method of preparing an HA (hydroxyapatite) coating layer comprises the following steps: mechanically grinding HA+AgNO3 and HA+norfloxacin according to a ratio of 4 to 1, pressing the material into a target with a diameter of 30 mmand a thickness of 5 mm on the premise of uniform mixing, putting the target into a pulse laser radiation vacuum cavity, and selecting quartz, a silicon wafer and a copper gauze to form a substrate; carrying out deposition by taking YAG:Nd<3+> as a laser source, thus obtaining a thin film sample. The HA with high biocompatibility is used as an implant coating layer material widely applied to plastic surgery, neurosurgery and dentistry; an HA thin film prepared by using a pulse laser deposition technology has a high degree of crystallinity and high bonding strength. The HA antibacterial coatinglayer obtained through the preparation method stabilizes antibiotic and silver particles on the surface of and in the film, so that the antibiotic and silver particles can fully exert an antibacterial effect.

Description

technical field [0001] The invention belongs to the technical field of coatings, and in particular relates to a medical antibacterial coating material and a preparation method thereof. Background technique [0002] Hydroxyapatite widely exists in the bones and teeth of animals, and also exists in some pathological tissues of the human body (such as salivary stones, brain stones, urethral stones, tonsil stones, nodular stones, and cervical posterior ligament ossification). Hydroxyapatite has excellent biological activity and can form chemical bonds on the interface after being implanted in the human body. [0003] Hydroxyapatite has excellent biocompatibility. It is not only safe and non-toxic to implant in the body, but also conducts bone growth, that is, new bone can follow the surface of the implant from the joint between the hydroxyapatite implant and the original bone. Or internal penetrating voids clinging and growing. Many scholars are committed to improving the mech...

Claims

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Application Information

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IPC IPC(8): A61L31/16A61L31/10A61L31/08
CPCA61L31/088A61L31/10A61L31/16A61L2300/404A61L2300/802A61L2420/02A61L2420/06C08L5/08
Inventor 江晓红王素瑞苗益鸣孙晋国冰利普左夫·德米特里雅德马连科·马克西姆罗加乔夫·亚历山大
Owner NANJING UNIV OF SCI & TECH
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