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Preparation method of hard tissue implant coating material

A technology for coating materials and implants, which can be used in coatings, tissue regeneration, prostheses, etc., can solve the problems of grain growth, easy mixing of impurities, etc., and achieve the effects of increased specific surface area, low production cost, and good crystal shape.

Inactive Publication Date: 2019-11-12
ZHEJIANG SCI-TECH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The powder prepared by the hydrothermal method generally does not need to be sintered, which can avoid the disadvantages of grain growth and easy mixing of impurities during the sintering process.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] 1) Accurately weigh 2.36g Ca(NO 3 ) 2 4H 2 O, 2.94g Na 3 C 6 h 5 o 7 2H 2 O, 2.28gNa 3 PO 4 12H 2 O, 0.5g NaHCO 3 , 0.38g NaF in corresponding numbered beakers, add 10g, 10g, 15g, 10g, 20g deionized water respectively, seal the beakers with plastic wrap, add 2 drops of polyethylene glycol 400 respectively, and stir at room temperature for 5-10min to prepare A solution with a certain concentration is ready for use;

[0032] 2) Transfer the calcium nitrate solution to the polytetrafluoroethylene lining, and add the sodium citrate solution dropwise to the calcium nitrate solution at a flow rate of 4 mL / min using a constant flow pump under stirring conditions. , stirring with a magnet for 5 minutes;

[0033] 3) Add the sodium fluoride solution dropwise to the mixed solution in step 2) at the same speed with a constant flow pump, and stir for 8 minutes after the dropwise addition;

[0034]4) Add the sodium phosphate solution dropwise to the mixed solution in ste...

Embodiment 2

[0041] 1) Accurately weigh 2.36g Ca(NO 3 ) 2 4H 2 O, 2.94g Na 3 C 6 h 5 o 7 2H 2 O, 2.28gNa 3 PO 4 12H 2 O, 0.546g NaHCO 3 , 1g NaF in a corresponding numbered beaker, add 2mL hydroxyethyl cellulose, add 10g, 10g, 15g, 10g, 20g deionized water respectively, seal the beaker with plastic wrap, stir at room temperature for 5min to prepare a solution of a certain concentration spare;

[0042] 2) Transfer the calcium nitrate solution to the polytetrafluoroethylene lining, and add the sodium citrate solution dropwise to the calcium nitrate solution at a flow rate of 4 mL / min using a constant flow pump under stirring conditions. , stirring with a magnet for 5 minutes;

[0043] 3) Add the sodium fluoride solution dropwise to the mixed solution in step 2) at the same speed with a constant flow pump, and stir for 10 minutes after the dropwise addition;

[0044] 4) Add the sodium phosphate solution dropwise to the mixed solution in step 3) at the same speed with a constant f...

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PUM

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Abstract

The invention relates to the field of implant coatings and discloses a preparation method of a hard tissue implant coating material. The bio-coating material with both thermal stability and bioactivity is prepared by a method with lower cost and adopting simple equipment. Carbonic acid and fluorine co-doped hydroxyapatite is prepared in the sequence of dropwise addition of sodium fluoride and sodium phosphate by a hydrothermal method, so that finally prepared particles have high purity, good dispersity, good and controllable crystal form and low production cost.

Description

technical field [0001] The invention relates to the field of implant coating, in particular to a preparation method of a hard tissue implant coating material. Background technique [0002] Hydroxyapatite has a similar composition and structure to hard tissues such as bone and teeth, and has good biological activity. It rarely causes immune rejection in medicine. It is a potential bone repair material, but the physical properties of hydroxyapatite The chemical stability is not good, and the degradation rate is fast. The hard tissue implant coating prepared by it is easy to fail in the human body and cause adverse effects. [0003] Carbonapatite has good biological activity and is a good bone graft coating material, but the doping of carbonate radicals will change the thermal expansion coefficient, which is the main factor affecting the combination of apatite coating and matrix ; Fluorine is one of the trace elements in the human body, and has a positive therapeutic effect on...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/32A61L27/30A61L27/34
CPCA61L27/306A61L27/32A61L27/34A61L2420/02A61L2420/06A61L2430/02C08L71/02
Inventor 彭志勤王晓云刘珉琦黄诗莹王秉万军民
Owner ZHEJIANG SCI-TECH UNIV
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