Berberine hydrochloride-matrine-carboxymethyl chitosan composite hydrogel and preparation method and application thereof
A technology of carboxymethyl chitosan and berberine hydrochloride, which is applied in the field of prevention or treatment of dairy cow mastitis, can solve the problems of easy flow of medicinal liquid and difficulty in continuously exerting medicinal effect, and achieves the effect of good bacteriostatic performance.
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Embodiment 1
[0034] Example 1 Preparation of berberine hydrochloride-matrine-carboxymethyl chitosan composite hydrogel
[0035] (1) Take 0.1g berberine hydrochloride and 0.8g matrine in 94ml pure water, heat in a water bath, add 5g carboxymethyl chitosan powder to it after fully dissolving, stir evenly with a magnetic stirrer, place overnight, The mixed solution 1 was obtained after fully absorbing and dissolving, and refrigerated for later use.
[0036] (2) Weigh 22g of poloxamer 407 and 6g of poloxamer 188 and dissolve them in 72ml of pre-cooled pure water, stir them with a magnetic stirrer to obtain a mixed solution 2, and refrigerate for later use.
[0037] (3) Mix the mixed solution 1 and the mixed solution 2 in a disposable plate according to the ratio of 2:1, mix well with a magnetic stirrer to prevent the generation of air bubbles, and let it stand on a constant temperature heating platform at 37°C for 10-15min. After solidification, it is sterilized by Co60 irradiation and refrig...
Embodiment 2
[0038] Example 2 Preparation of berberine hydrochloride-matrine-carboxymethyl chitosan composite hydrogel
[0039] (1) Take 0.05g berberine hydrochloride and 0.5g matrine in 94ml pure water, heat in a water bath, add 6g carboxymethyl chitosan powder to it after fully dissolving, stir evenly with a magnetic stirrer, place overnight, The mixed solution 1 was obtained after fully absorbing and dissolving, and refrigerated for later use.
[0040] (2) Weigh 10 g of Poloxamer 407 and 2 g of Poloxamer 407 and dissolve them in 88 ml of pre-cooled pure water, stir with a magnetic stirrer to obtain a mixed solution 2, and refrigerate for later use.
[0041] (3) Mix the mixed solution 1 and the mixed solution 2 in a disposable plate according to the ratio of 3:1, mix well with a magnetic stirrer to prevent the generation of air bubbles, and let it stand on a constant temperature heating platform at 37°C for 10-15min. After solidification, it is sterilized by Co60 irradiation and refrige...
Embodiment 3
[0042] Example 3 Preparation of berberine hydrochloride-matrine-carboxymethyl chitosan composite hydrogel
[0043] (1) Weigh 0.5g berberine hydrochloride and 3g matrine in 94ml pure water, heat in a water bath, add 2g carboxymethyl chitosan powder to it after fully dissolving, stir evenly with a magnetic stirrer, place overnight, fully After absorbing and dissolving, the mixed solution 1 was obtained and refrigerated for later use.
[0044] (2) Weigh 30 g of Poloxamer 407 and 10 g of Poloxamer 407 and dissolve in 70 ml of pre-cooled pure water, stir with a magnetic stirrer to obtain a mixed solution 2, and refrigerate for later use.
[0045] (3) Mix the mixed solution 1 and the mixed solution 2 in a disposable plate according to the ratio of 5:3, and mix it with a magnetic stirrer to prevent the generation of air bubbles. Let it stand on a constant temperature heating platform at 37°C for 10-15min, and wait for it After solidification, it is sterilized by Co60 irradiation and...
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