Microneedle patch for relieving skin acnes and preparation method thereof

A technology for improving skin and micro-needle stickers, applied in the field of medicine, can solve the problems of expensive micro-needle acne treatment projects, exudation of tissue fluid, severe pain and itching, achieve good absorption effect, promote re-infiltration and absorption, and alleviate acne symptoms. Effect

CN110755529AActive Publication Date: 2020-02-07广州新济薇娜生物科技有限公司
3 Cites 4 Cited by

Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
Publication Date
2020-02-07

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention relates to a microneedle patch for relieving skin acnes and a preparation method thereof. The microneedle patch comprises needle points and a base with holes, wherein raw materials of the needle points comprise soluble materials and medicine for relieving the skin acnes; raw materials of the base with holes comprise an excipient, a penetrating agent and medicine for relieving the skin acnes; the medicine for relieving the skin acnes is in the needle points and the base with the holes and is respectively and independently selected from at least one of vitamin A type medicine, radix salviae miltiorrhizae extracts, chrysanthemum flower extracts, benzoperoxide, eugenol, aloe extracts, azelaic acid and salicylic acid; the soluble material comprises at least one of hyaluronic acidand hyaluronate; and the excipient comprises polyvinyl alcohol and lactic acid / hydroxyacetic acid copolymers. The microneedle patch can fast achieve good anti-acne effects, and can also effectively prevent the pore blockage and secondary infection.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention relates to the field of medicine, in particular to a microneedle patch for improving skin acne and a preparation method thereof. Background technique

[0002] Facial acne, commonly known as acne, is a common facial skin disease. The pathogenesis of acne is still not fully elucidated. Hormone-induced sebaceous gland excessive secretion of lipids, abnormal keratinization of pilosebaceous gland ducts, proliferation of hair follicle microorganisms such as Propionibacterium acnes, and inflammation and immune responses in the genetic background are related to it. Genetic factors play an important role in the occurrence of acne, especially severe acne; androgen is the main inducing factor leading to sebaceous hyperplasia and massive lipid secretion, and other hormones such as insulin-like growth factor-1 (IGF-1), insulin, growth hormone, etc. It may also be related to acne; a large amount of lipid secretion by sebaceous glands is considered a ...

Examples

preparation example Construction

[0045] This embodiment also provides a method for preparing the above-mentioned microneedle patch, which includes the following steps:

[0046] (1) Preparation of porous substrate: mix excipients, penetrants and drugs for improving skin acne with water and dichloromethane, pour the obtained substrate solution into the negative mold of the microneedle substrate, press under vacuum, freeze and thaw Repeat 1 to 3 times to dehydrate to obtain a substrate with holes;

[0047] (2) Preparation of microneedle liquid: dissolving the soluble material in water, adding the medicine for improving skin acne, to obtain microneedle liquid;

[0048] (3) Preparation of microneedle patch: Pour the microneedle liquid into the microneedle female mold, place the perforated base on the microneedle liquid with the holes facing down, press under vacuum to remove solvent and water.

[0049] The excipients and penetrants in the base help to cross-link into a network microporous structure after repeated...

Embodiment 1

[0070] The present disclosure also provides a method for preparing a microneedle patch for acne removal and beauty treatment, comprising the following steps:

[0071] (1) Preparation of slow-dissolving porous substrate: Weigh the following components by weight and mix them: 20 parts of lactic acid / glycolic acid copolymer, 0.5 part of eugenol, 0.5 part of borneol, 1 part of benzoyl peroxide dissolved in 80 parts of two In methyl chloride, 10 parts of polyvinyl alcohol, 0.3 part of Danshen extract, 0.5 part of chrysanthemum extract, and 2 parts of aloe extract were dissolved in 150 parts of water. Mix and emulsify the above components, make a solution and pour it into a special female mold 1 that can be made into a shape with holes (the shape of the female mold 1 is as follows: figure 1 shown), pressed at -0.07mpa vacuum, frozen at a temperature of about -20°C for 6-12 hours, and thawed at room temperature for 1-2 hours. The above-mentioned freezing and thawing process was repea...

Embodiment 2

[0077] (1) Preparation of slow-dissolving porous base: Weigh the following components by weight and mix them: 10 parts of lactic acid / glycolic acid copolymer, 0.5 part of borneol, 0.5 part of eugenol, and 1 part of benzoyl peroxide are dissolved in 60 parts of two In methyl chloride, 20 parts of polyvinyl alcohol, 0.3 part of Danshen extract, 0.5 part of chrysanthemum extract, and 2 parts of aloe extract were dissolved in 180 parts of water. Mix and emulsify the above components, make a solution, pour it into a special female mold 1 that can be made into a shape with holes, press it under a vacuum of -0.07mpa, and freeze it at a temperature of about -20°C for 6 to 12 hours. thawing at low temperature for 1-2 hours, the above freezing and thawing process was repeated 1-3 times, and then vacuum dehydration and solvent were performed, and after drying, a perforated substrate with long solubility was obtained.

[0078] (2) Preparation of soluble microneedle liquid: Weigh and mix t...