Unlock instant, AI-driven research and patent intelligence for your innovation.

Il-8 inhibitors for use in treatment and/or prevention of bacterial secondary infections

A bacterial infection, 1. IL-8 technology, applied in the direction of antibacterial drugs, medical preparations containing active ingredients, anti-animal/human immunoglobulin, etc., can solve the problem of increased lethality

Active Publication Date: 2020-02-07
DOMPE FARM SPA
View PDF11 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This condition is not unique to epidemics, as other types of serious infections (such as sepsis) may cause similar conditions in experimental systems and lead to the increased lethality observed in humans after sepsis

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Il-8 inhibitors for use in treatment and/or prevention of bacterial secondary infections
  • Il-8 inhibitors for use in treatment and/or prevention of bacterial secondary infections
  • Il-8 inhibitors for use in treatment and/or prevention of bacterial secondary infections

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0129] Materials and methods

[0130] mouse

[0131] Male C57BL / 6J mice (8-12 weeks old) were obtained from the Central Animal Facility of the Federal University of Minas Gerais (CEBIO UFMG / Brazil) and maintained with free access to commercial food and water. All procedures described have been previously approved by the local animal ethics committee (CETEA / UFMG 13 / 2010 and 381 / 2015).

[0132] Bacteria and Virus Strains

[0133] Streptococcus pneumoniae (ATCC 6303 serotype 3) at 37°C and 5% CO 2 Grow on blood agar plates for 12 hours and prepare infection stocks as described (Tavares, L.P., et al., Inhibition of PDE4 During Pneumococcal Pneumonia Reduces Inflammation and Lung Injury in Mice. Am J Respir Cell Mol Biol, 2015). Inoculum is usually confirmed by plating a bacterial suspension.

[0134] Mouse-adapted influenza virus A / WSN / 33H1N1 (referred to herein as IAV) was grown in MDCK (Madin-Darby Canine Kidney) culture cells as described in (Garcia, C.C. et al., Platelet...

Embodiment 2

[0166] Role of the CXCR1 / 2 pathway in a mouse model of exacerbated pneumonia in combination virus (influenza A) infection and cigarette smoke exposure

[0167] Chronic obstructive pulmonary disease (COPD) is a health problem of global importance with increasing prevalence, accounting for approximately 5% of all deaths worldwide. The disease is characterized by persistent airflow limitation, which is usually progressive and is associated with an enhanced chronic inflammatory response of the lung airways to noxious particles or gases (Sethi, S. et al. Am.J.Med. 125, 1162 –1170; 2012). Smoking is a major risk factor for which there is no adequate treatment.

[0168] Increased neutrophils in lung tissue are a hallmark of COPD patients, usually accompanied by overproduction of inflammatory cytokines (such as TNF-α, IL-6 and IL-8, etc.). Although neutrophils are undoubtedly the main contributors to acute inflammation, several lines of evidence suggest that they may also contribute...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The present invention relates to IL-8 inhibitor compounds, preferably dual CXCR1 / CXCR2 receptor inhibitors, useful in the treatment and / or prevention of secondary bacterial infections, preferably secondary respiratory infections.

Description

technical field [0001] The present invention relates to IL-8 inhibitors for preventing and / or treating secondary bacterial infections, preferably secondary respiratory tract infections. The secondary bacterial infection is associated with previous influenza infection, sepsis, severe ischemia or reperfusion injury. Background technique [0002] The lungs consist of numerous dendritic branches terminating in densely vascularized alveoli. The mucosal surface of the lung is very large (90m 2 ), exposed to a large number of particles and microorganisms including pathogens every day (Kopf, M., C. Schneider and S.P. Nobs, The development and function of lung-resident macrophages and dendritic cells. Nat Immunol, 2015.16 (1): No. 36- 44 pages). Thus, numerous physical and biological barriers, including the innate immune system, protect the lungs from possible infections. Pro-inflammatory cytokines and chemokines, produced by resident immune cells and lung epithelial cells, promo...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/427A61P31/04
CPCA61K31/427A61P31/04A61P31/16A61K31/192A61K2039/505A61K31/426C07K16/28A61K31/18
Inventor L·巴瑞多里尼M·阿莱格雷蒂M·M·特谢拉
Owner DOMPE FARM SPA