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Method for promoting hair regeneration based on plasmas

A plasma and cold plasma technology, applied in the field of regenerative medicine, can solve the problems of unseen hair follicle regeneration and hair regeneration

Inactive Publication Date: 2020-02-14
SHENZHEN GRADUATE SCHOOL TSINGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are international studies on the application of plasma to promote chronic wound healing, blood coagulation, fracture healing, etc., but there are no relevant reports on promoting hair follicle regeneration and hair regeneration.

Method used

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  • Method for promoting hair regeneration based on plasmas
  • Method for promoting hair regeneration based on plasmas
  • Method for promoting hair regeneration based on plasmas

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] experimental method

[0023] 7-8 week old C57Bl / 6 mice (hair follicles in quiescent phase) were randomly divided into experimental group and control group, with 6 mice in each group. The back of the mouse was depilated with a depilatory cream, and four areas with a diameter of 5 mm were selected as treatment sites on the symmetrical parts of the back of the mouse (see figure 1 ), in order to further ensure that the plasma flow does not spread to areas other than the treatment site, the skin of the non-treatment site is protected with a 3M film.

[0024] The treatment site in the experimental group was irradiated with a cold plasma flow with a width of 5 mm, the plasma intensity (power supply voltage) was 12 volts, and the irradiation time was 3 minutes each time, once a day for 3 consecutive days. transmitters (such as Figure 5 ), the cold plasma flow has a clear boundary and no scattering flow. A control group underwent the same procedure but without plasma irradia...

Embodiment 2

[0028] Embodiment 2, investigate the impact of irradiation intensity on the ability to promote regeneration

[0029] Irradiate with a cold plasma flow with a width of 5 mm, keep the intensity of the plasma constant (power supply voltage 12 volts), and irradiate for 1 minute, 10 minutes, and 30 minutes respectively (the three times correspond to C, D, and E diagrams), once a day , continuously irradiated for three days, and after 10 days, it was found that the hair regeneration within a certain range was related to the plasma treatment time, and the number of hair follicle regeneration increased significantly with the increase of treatment time, but its ability to promote regeneration after a certain treatment time decreased ( Figure 4 ).

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Abstract

The invention provides a method for promoting hair regeneration based on plasmas. The method is as follows: cold plasmas are used for irradiating skin to activate hair follicle stem cells, and hair regeneration is promoted. Experiments prove that atrophic hair follicles are immediately activated after plasma jet treatment is performed on the skin of 7-8 weeks old mice in a rest period (hair follicle atrophy), so that the hair follicles are regenerated to form new hair follicles, and hair grows out.

Description

technical field [0001] The invention belongs to the field of regenerative medicine, in particular to a method for promoting hair regeneration based on plasma. Background technique [0002] Plasma (Plasma) is a kind of material form produced by partial ionization of gas under high-voltage discharge, with free electrons and charged ions as the main components. It is called the fourth form of matter except solid state, liquid state and gaseous state. Its main active components contain a large number of active particles, such as electrons, ions, free radicals (ROS and RNS), molecules, and electrically neutral atoms. The active components and content in these plasma jets will vary with some parameters. Different, such as changes in ion source structure, frequency, voltage, gas composition and other parameters will also cause differences in its composition and content. [0003] Plasma has a strong inactivation effect on bacteria, and its initial application in the field of biolog...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61N5/10
CPCA61N5/10A61N2005/1021
Inventor 吴耀炯张若兵孔德强徐国旺
Owner SHENZHEN GRADUATE SCHOOL TSINGHUA UNIV
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