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Application of phthalide compounds in angelica sinensis in preventing and treating agricultural diseases

A disease and angelica technology, applied in the fields of application, animal husbandry, biocide, etc., to achieve the effect of high bactericidal activity, wide bactericidal spectrum, and good inhibitory activity

Inactive Publication Date: 2020-02-18
LANZHOU UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are few research reports on the structure of phthalides such as ligustilide, ligustilide A, 3-n-butenylphthalide and n-butylphthalide in angelica for the prevention and treatment of plant pathogenic fungi.

Method used

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  • Application of phthalide compounds in angelica sinensis in preventing and treating agricultural diseases
  • Application of phthalide compounds in angelica sinensis in preventing and treating agricultural diseases
  • Application of phthalide compounds in angelica sinensis in preventing and treating agricultural diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Example 1: Chemical formulas (D1) to (D4) were isolated, and their structural identifications were consistent with those reported in literature. Ligustilide (D1) CAS: 4431-01-0, purity > 98%; Ligustilide A (D2) CAS: 62006-39-7, purity > 98%; 3-n-butenylphthalide ( D3) CAS: 551-08-6, purity > 98%; n-butylphthalide (D4) CAS: 6066-49-5, purity > 98%; Angelica volatile oil is steam distilled according to the Pharmacopoeia of the People's Republic of China made by law.

[0013]

Embodiment 2

[0014] Embodiment 2: Indoor antibacterial activity assay and result

[0015] The phytopathogenic bacteria used in this experiment were strains stored at 4°C in the laboratory, and the medium used was potato agar dextrose medium (abbreviated as PDA). PDA medium formula: potato (peeled) 200g, glucose 20g, agar 15g, distilled water 1000mL, natural pH.

[0016] Preparation method: Wash and peel the potatoes, weigh 200g and cut into small pieces, add water and boil until rotten (boil for 20-30 minutes, it can be pierced by a glass rod), filter with four layers of gauze and fill the beaker with water to 1000mL, According to the needs of the experiment, add 15-20g of agar, add 20g of glucose, stir to make it fully dissolved, then pack it in a triangular flask, sterilize at 121°C for 20 minutes, and cool it for later use.

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PUM

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Abstract

The invention belongs to the field of natural pharmaceutical chemistry, and discloses an application of ligustilide, senkyunolide A, 3-n-butylidene phthalide and n-butyl phthalide in preventing and treating diseases caused by rhizoctonia solani, sclerotinia sclerotiorum, botrytis cinerea, gibberella zeae, magnaporthe grisea and fusarium oxysporum vasinfectum. Particularly, 3-n-butylidene phthalideexhibits an excellent inhibition effect on rhizoctonia solani and gibberella zeae. The application can be used for preparing agricultural sterilization lead compounds, and has a good development prospect.

Description

technical field [0001] The invention belongs to the field of natural medicinal chemistry, and discloses new uses of four phthalide compounds, ligustilide, ligustilide A, 3-n-butenylphthalide and n-butylphthalide, derived from Angelica sinensis. The invention relates to its use in preventing and controlling diseases caused by Sclerotinia sclerotiorum, Rhizoctonia solani, Botrytis cinerea, wheat scab, cotton fusarium wilt and rice blast. Background technique [0002] Plant disease is one of the main factors affecting agricultural production. According to the estimation of the Food and Agriculture Organization of the United Nations, the annual loss of grain and cotton production in the world is more than 10% due to disease. At present, the prevention and control of plant diseases in the world mainly uses chemical agents. However, due to the long-term use of chemical agents, a series of serious problems such as residues, pollution, resistance of harmful organisms, damage to non-...

Claims

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Application Information

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IPC IPC(8): A01N43/08A01P3/00
CPCA01N43/08
Inventor 刘映前孙钰杨志刚杨程杰柳军玺吴争荣张智军秦芳王仁轩
Owner LANZHOU UNIVERSITY
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