Extraction process of total flavonoids of overground part of bupleurum chinense cultivated in Ningxia

An aerial part and extraction process technology, which is applied in the field of extraction process of total flavonoids from aerial parts of cultivated Bupleurum chinensis in Ningxia, can solve the problems of unfavorable industrial production, long extraction time, low extraction rate, etc., and is convenient for large-scale production and easy to propose. , The effect of simple and easy process

Inactive Publication Date: 2020-02-21
NINGXIA VOCATIONAL TECH COLLEGE
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In the prior art, extracting total flavonoids from Bupleurum radix is ​​generally directly heated and refluxed with high-concentration ethanol. Not only the extraction rate is not high, but also the extraction time is long and the process is complicated, which is not conducive to industrial production.

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  • Extraction process of total flavonoids of overground part of bupleurum chinense cultivated in Ningxia
  • Extraction process of total flavonoids of overground part of bupleurum chinense cultivated in Ningxia

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Embodiment 1

[0029] The extraction process of the total flavonoids of the above-ground part of Bupleurum bupleuri cultivated in Ningxia in this embodiment includes four steps of crushing, soaking at room temperature, static heating and reflux extraction and concentration;

[0030] The extraction process of the total flavonoids of the above-ground part of Bupleurum bupleurum is specifically as follows:

[0031] Step 1, crushing, selecting the aerial part of Bupleurum bupleuri cultivated in Ningxia, drying it naturally, crushing it with a small swinging grinder and passing through No.

[0032] Step 2. Soaking at room temperature: put the coarse powder of Bupleurum above ground into the extraction container, add 55% ethanol, and soak for 50 minutes at room temperature, wherein the ratio of solid to liquid of coarse powder of Bupleurum above ground and 55% ethanol is 0.8:11;

[0033] Step 3, static reflux extraction: after airtight immersion in 55% ethanol at room temperature, use static heati...

Embodiment 2

[0036] Refer to the attached figure 1 , the extraction process of the total flavonoids of the above-ground part of Bupleurum bupleuri cultivated in Ningxia in this embodiment includes four steps of crushing, soaking at room temperature, static heating and reflux extraction and concentration;

[0037] The extraction process of the total flavonoids of the above-ground part of Bupleurum bupleurum is specifically as follows:

[0038] Step 1, crushing: the aerial part of Bupleurum bupleuri cultivated in Ningxia is selected, aired naturally, pulverized with a small swing pulverizer and passed through a No.

[0039] Step 2. Soaking at room temperature: put the coarse powder of Bupleurum above ground into the extraction container, add 55% ethanol, and soak for 60 minutes at room temperature, wherein the ratio of solid to liquid of coarse powder of Bupleurum above ground and 55% ethanol is 1:10;

[0040] Step 3, static reflux extraction: after airtight immersion in 55% ethanol at room...

Embodiment 3

[0043] The extraction process of the total flavonoids of the above-ground part of Bupleurum bupleuri cultivated in Ningxia in this embodiment includes four steps of crushing, soaking at room temperature, static heating and reflux extraction and concentration;

[0044] The extraction process of the total flavonoids of the above-ground part of Bupleurum bupleurum is specifically as follows:

[0045] Step 1, crushing: the aerial part of Bupleurum bupleurum cultivated in Ningxia is selected, dried naturally, pulverized with a small swing pulverizer and passed through a No.

[0046] Step 2. Soaking at room temperature: put the coarse powder of Bupleurum above ground into the extraction container, add 55% ethanol, and soak for 70 minutes at room temperature, wherein the ratio of solid to liquid between the coarse powder of Bupleurum above ground and 55% ethanol is 1:9;

[0047]Step 3, static reflux extraction: after airtight immersion in 55% ethanol at room temperature, use the stat...

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Abstract

The embodiment of the invention discloses an extraction process of total flavonoids of an overground part of bupleurum chinense cultivated in Ningxia, and particularly relates to the field of extraction processes of total flavonoids. The process comprises four steps of crushing, room-temperature soaking, static heating reflux extraction and concentration, and specifically comprises the following steps: crushing a cleaned and selected overground part of bupleurum chinense, and sieving the crushed overground part with a Chinese pharmacopeia No.2 sieve; loading the crushed overground part of bupleurum chinense into an extraction container, adding 55% ethanol according to a solid-to-liquid ratio of 1:10, and performing hermetical soaking at room temperature for 60 minutes; performing static heating reflux extraction for three times each for 72 min according to a solid-liquid ratio of 1:10, and combining extracted filtrate; and concentrating the filtrate under reduced pressure at 56 DEG C or below until a solvent is completely evaporated to dryness to obtain dry extractum. According to the invention, the processes of the crushing, the room-temperature soaking, the reflux extraction, theconcentration and the like are adopted to obtain the total extracted dry extractum of the overground part of bupleurum chinense, and the extraction rate of the total flavonoids reaches 3.7%. The process is simple and feasible, and industrial production is convenient to realize.

Description

technical field [0001] The embodiment of the present invention relates to the field of extraction technology of total flavonoids, in particular to the extraction technology of total flavonoids from the aerial part of Bupleurum bupleuri cultivated in Ningxia. Background technique [0002] Bupleurum is derived from the plants of the genus Bupleurum L. in the family Umbelliferae. It is a commonly used traditional Chinese medicine, and its roots are mainly used as medicine at present. Slightly cold in nature, pungent and bitter in taste, it has the effects of dispersing and reducing fever, soothing the liver and promoting yang, and it is mainly used to treat colds and fever, alternating cold and heat, malaria, irregular menstruation and uterine prolapse. The medicinal and active chemical components of Bupleurum are mainly saponins, flavonoids, volatile oils, phytosterols and polysaccharides, among which Bupleurum flavonoids have strong anti-influenza virus effects, and have good...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/233A61P31/16A61P29/00A61P31/04A61K135/00A61K127/00
CPCA61K36/233A61K2236/15A61K2236/333A61K2236/39A61K2236/51A61P29/00A61P31/04A61P31/16
Inventor 郝彩琴冷晓红李军陈海燕郭超郭鸿雁徐超刘立轩
Owner NINGXIA VOCATIONAL TECH COLLEGE
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