Far-infrared detection method of drugs

A detection method, far-infrared technology, applied in measuring devices, material analysis through optical means, instruments, etc., can solve the problems of low resolution, poor quantification, and complicated operation of chromatography and mass spectrometry in ion mobility spectrometry, and achieve The effect of improving detection efficiency, fast non-destructive testing, and shortening testing time

Inactive Publication Date: 2020-02-21
SHANGHAI INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, the chemical detection method is not easy to detect drugs with low content and similar chemical structure, and the impurities contained will affect the accuracy of the test results. It is mostly used in laboratories and cannot achieve rapid detection.
Drugs can only see the external shape under X-rays, and cannot be analyzed qualitatively, and X-rays have certain radiation hazards to the human body, especially sensitive groups such as pregnant women and children need to avoid exposure to X-rays as much as possible
Therefore, in most cases, X-rays can only be used for object detection, not for human detection.
Ion mobility spectrometry has low resolution, poor quantitation, and can only detect in the lower concentration range
Chromatography and mass spectrometry are complex and costly, and are not suitable for on-site detection of drugs

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Example 1: Take cocaine as an example

[0032] The invention provides a kind of far-infrared detection method of cocaine, and concrete steps are as follows:

[0033] Step 1: Prepare a standard sample of cocaine:

[0034] Take 1 mL of cocaine standard substance with a concentration of 1 mg / mL, drop it on a filter membrane with a diameter of 13 mm, and dry it at 40 ° C to obtain a standard sample of cocaine;

[0035] Step 2: Experimental measurement and establishment of a standard spectral library:

[0036]The standard sample of cocaine that step 1 obtains is put into the sample tank of the instrument, and the instrument is vacuumized, then utilizes the FTIR far-infrared band to measure, and the test environment temperature is 21° C., and detects under vacuum conditions; the far-infrared absorption spectrum of the drug standard The frequency range is 30-350cm -1 ; The number of scans of the instrument is 128 times, and the resolution is 2cm -1 ; Each sample was tested...

Embodiment 2

[0038] Embodiment 2: Taking ketamine hydrochloride as an example

[0039] The invention provides a far-infrared detection method of ketamine hydrochloride, the specific steps are as follows:

[0040] Step 1: Prepare standard samples of ketamine hydrochloride:

[0041] Take 1 mL of ketamine hydrochloride standard substance with a concentration of 1 mg / mL, drop it on a filter membrane with a diameter of 13 mm, and dry it at 40 ° C to obtain a standard sample of ketamine hydrochloride;

[0042] Step 2: Experimental measurement and establishment of a standard spectral library:

[0043] Put the standard sample of ketamine hydrochloride obtained in step 1 into the sample tank of the instrument, vacuumize the instrument, and then use the FTIR far-infrared band to measure, the test environment temperature is 21 ° C, and detect under vacuum conditions; the far-infrared absorption spectrum of the drug standard The frequency range is 30-350cm -1 ; The number of scans of the instrument...

Embodiment 3

[0045] Example 3: Taking Cannabidiol as an Example

[0046] The invention provides a far-infrared detection method of cannabinol, the specific steps are as follows:

[0047] Step 1: Preparation of standard samples of cannabinol:

[0048] Take 1 mL of cannabinol standard substance with a concentration of 1 mg / mL, drop it on a filter membrane with a diameter of 13 mm, and dry it at 40 ° C to obtain a standard sample of cannabinol;

[0049] Step 2: Experimental measurement and establishment of a standard spectral library:

[0050] Put the standard sample of cannabinol obtained in step 1 into the sample tank of the instrument, vacuumize the instrument, and then use the FTIR far-infrared band to measure. The test environment temperature is 21°C, and it is tested under vacuum conditions. The frequency range of the far-infrared absorption spectrum of the drug standard is 30-350cm -1 , the number of scans of the instrument is 128 times, and the resolution is 2cm -1 , each sample w...

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Abstract

The invention discloses a far-infrared detection method of drugs. The drugs comprise cocaine, ketamine hydrochloride, cannabinol, morphine and heroin. The far-infrared detection method of the drugs comprises the following steps that 1, standard substance samples of the drugs are prepared; 2, the far-infrared detection technology is used for detecting standard substances of the drugs and constructing a standard dactylogram library; and 3, the constructed standard dactylogram library is used for detecting unknown objects. According to the far-infrared detection method of the drugs, the far-infrared detection technology is used for constructing the fingerprint spectrum library of the five drugs, and the dactylogram library is used for quickly detecting whether the unknown objects are the drugor not. Far-infrared wave photons are low in energy and high in penetrating power, and do not cause harm to a human body, and nondestructive detection can be realized.

Description

technical field [0001] The invention belongs to the technical field of drug detection, and in particular relates to a detection method for constructing standard fingerprints of drugs by using far-infrared waves. Background technique [0002] Drugs seriously endanger human health and social peace, and are a major public hazard to society. Drug addicts have an extremely strong desire for drugs after becoming addicted to drugs. In order to satisfy drug addiction, they will obtain drugs by any means, which seriously disrupts social order and causes national and national crises. Prevention and control of drug flooding is an important part of the government's work. How to quickly discover and detect drugs is an urgent problem for customs and public security departments to solve and control drugs. [0003] Some existing techniques for detecting drugs include: chemical method, spectroscopic method, ion mobility spectrometry, chromatography, mass spectrometry and combined technology...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/3581G01N21/3577
CPCG01N21/3577G01N21/3581
Inventor 马霞张志远田桢干
Owner SHANGHAI INST OF TECH
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