Application of pyrazolopyrimidine derivative for treating acute pancreatitis

A technology for acute pancreatitis and pyrazolopyrimidine, which can be applied to medical preparations containing active ingredients, drug combinations, organic active ingredients, etc. , Expanding the scope of application, the effect of multiple drug selection

Active Publication Date: 2020-02-25
GUANGXI WUZHOU PHARMA GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] At present, there are only reports about pyrazolopyrimidine derivatives in the treatment of acute myeloid leukemia and psoriasis, but there is no report on the treatment of acute pancreatitis use

Method used

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  • Application of pyrazolopyrimidine derivative for treating acute pancreatitis
  • Application of pyrazolopyrimidine derivative for treating acute pancreatitis
  • Application of pyrazolopyrimidine derivative for treating acute pancreatitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Example 1 Effects on Severe Acute Pancreatitis Rats

[0034] 1. Experimental animals: clean-grade SD rats, male, weighing 200-250 g, purchased from Beijing Weitong Lihua Experimental Animal Technology Co., Ltd.

[0035] 2. Experimental materials: pyrazolopyrimidine derivatives were synthesized by the inventors. Pyrazolopyrimidine derivatives were synthesized by the inventors. Mix castor oil and ethanol 1:1 and pass through a 0.22 μm sterile filter membrane to obtain ELE solution, weigh a certain amount of pyrazolopyrimidine derivative powder of the present invention, dissolve the powder with ELE solution, and after the powder is completely dissolved, Add a certain volume of sterilized water, mix well and set aside. The volume ratio of ELE solution to sterile water is 1:3. L-arginine (l-arginine, sigma), interleukin 10 (rhIL-10, Protech).

[0036] 3. Grouping of animals: Rats were randomly divided into blank control group, model group, positive drug group, and pyrazo...

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Abstract

The invention relates to the technical field of medicines, in particular to an application of a pyrazolopyrimidine derivative in treating acute pancreatitis. The pyrazolopyrimidine derivative has thegood treatment effect on acute pancreatitis, can significantly improve the edema degree, inflammatory cell infiltration, necrosis and other symptoms of pancreatic tissue, significantly reduces the contents of ET and TXA2 in pancreatic tissue, and has the treatment effect equal to or even superior to that of human recombinant interleukin 10.

Description

technical field [0001] The invention relates to the technical field of medicines, in particular to the use of pyrazolopyrimidine derivatives in treating acute pancreatitis. Background technique [0002] Acute pancreatitis (AP) is the overactivation of pancreatic enzymes in pancreatic tissue caused by a variety of factors, causing a series of inflammatory reactions such as digestion, hemorrhage, edema, and necrosis of pancreatic tissue itself, with or without multiple The functional change of organs is one of the common acute abdomen in clinic. In my country, its incidence rate is about 13-45 / 100000, among which 20% of the patients, if timely and effective treatment measures are not taken, the condition may further progress to severe acute pancreatitis (Severe Acute Pancreatitis, SAP), the condition of SAP is complicated, and the course of the disease is Dangerous, difficult to treat, the mortality rate is as high as 30%. [0003] The 2012 Atlanta diagnostic criteria for AP ...

Claims

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Application Information

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IPC IPC(8): A61K31/519A61P1/18
CPCA61K31/519A61P1/18
Inventor 赖树生欧阳静波巫鑫钟杰敏卢蕾羽李鑫韦张静
Owner GUANGXI WUZHOU PHARMA GRP
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