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Application of pyrazolopyrimidine derivative for treating liver injury caused by acute pancreatitis

A technology for acute pancreatitis and pyrazolopyrimidine, which can be applied to medical preparations containing active ingredients, drug combinations, organic active ingredients, etc. Selective, reduced tissue damage, good therapeutic effect

Active Publication Date: 2020-02-25
GUANGXI WUZHOU PHARMA GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] At present, there are only reports about pyrazolopyrimidine derivatives in the treatment of acute myeloid leukemia and psoriasis, but there is no report on the treatment of liver disease caused by acute pancreatitis. Injury Use

Method used

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  • Application of pyrazolopyrimidine derivative for treating liver injury caused by acute pancreatitis
  • Application of pyrazolopyrimidine derivative for treating liver injury caused by acute pancreatitis
  • Application of pyrazolopyrimidine derivative for treating liver injury caused by acute pancreatitis

Examples

Experimental program
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Effect test

Embodiment 1

[0038] Example 1 Study on the effect of severe acute pancreatitis on liver injury in rats

[0039] 1. Experimental animals: clean-grade SD rats, half male and half male, weighing 180-220 g, purchased from Beijing Weitong Lihua Experimental Animal Technology Co., Ltd.

[0040] 2. Experimental materials: pyrazolopyrimidine derivatives were synthesized by the inventors. Pyrazolopyrimidine derivatives were synthesized by the inventors. Mix castor oil and ethanol 1:1 and pass through a 0.22 μm sterile filter membrane to obtain ELE solution, weigh a certain amount of pyrazolopyrimidine derivative powder of the present invention, dissolve the powder with ELE solution, and after the powder is completely dissolved, Add a certain volume of sterilized water, mix well and set aside. The volume ratio of ELE solution to sterile water is 1:3.

[0041]3. Animal grouping, modeling, administration: All animals were randomly divided into the following groups: blank control group (10 animals),...

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Abstract

The invention relates to the technical field of medicines, in particular to an application of a pyrazolopyrimidine derivative in treating liver injury caused by acute pancreatitis. The pyrazolopyrimidine derivative disclosed by the invention has the relatively good treatment effect on liver injury caused by acute pancreatitis, the contents of AMY, AST and ALT in serum can be obviously reduced, thetraditional Chinese medicine composition can effectively reduce the damage degree of pancreatic tissues and liver tissues, improve the content level of an anti-inflammatory factor IL-10 in serum, reduce the level of an inflammatory factor IL-6 in the serum and inhibit the overexpression of NF-kappa B in the liver tissues, so that the development of inflammatory response in the liver tissues is effectively controlled, and the tissue damage caused by the inflammatory response is reduced.

Description

technical field [0001] The invention relates to the technical field of medicines, in particular to the use of pyrazolopyrimidine derivatives in treating liver damage caused by acute pancreatitis. Background technique [0002] Acute pancreatitis (AP) is a common clinical disease and frequently-occurring disease. According to its clinical manifestations, it can be divided into three categories: mild acute pancreatitis (MAP), severe acute pancreatitis (SAP) and moderate to severe acute pancreatitis ( MSAP). Clinically, most AP patients are self-limiting, 20% to 30% of patients experience danger, and the overall fatality rate is 5% to 10%. The fatality rate of SAP is relatively high, up to 36% to 50%. The case fatality rate is higher. At present, the pathogenesis of severe acute pancreatitis is not yet fully understood, especially for severe cases complicated by other organ damage, there is still a lack of effective clinical treatment. Among patients with SAP complicated by m...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/519A61P1/16A61P1/18
CPCA61K31/519A61P1/16A61P1/18
Inventor 欧阳静波陈焕展钟杰敏李柏霖吴水华林艳英
Owner GUANGXI WUZHOU PHARMA GRP
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