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Application of metformin in drugs for treating endometriosis

A metformin and endometrium technology, applied in the field of medical applications, can solve the problems of no clinical randomized controlled study, no setting of endometrial receptivity, etc., and achieve great medical application value and socioeconomic value, and improve fertility. Effect

Pending Publication Date: 2020-02-28
THE WEST CHINA SECOND UNIV HOSPITAL OF SICHUAN
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Problems solved by technology

However, with the continuous research on endometriosis-related infertility, it has been found that the decline in endometriosis endometrial receptivity is one of the important factors affecting embryo implantation and pregnancy maintenance in patients with endometriosis. There is a lack of clinical research on endometrium receptivity in patients with endometriosis and there is no effective choice of drugs. Although some studies have suggested the relevant treatment and effects on endometriosis, they have not been set in terms of endometrium receptivity, and There are no clinical randomized controlled studies focusing on endometrial receptivity

Method used

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  • Application of metformin in drugs for treating endometriosis
  • Application of metformin in drugs for treating endometriosis
  • Application of metformin in drugs for treating endometriosis

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Embodiment Construction

[0020] The present invention will be further described in detail below in conjunction with examples, but the embodiments of the present invention are not limited thereto.

[0021] The invention relates to the application of metformin in the treatment and improvement of endometriosis medicine, especially the application of the medicine in the endometrial receptivity of infertile patients. We know that metformin is widely used in the treatment of diabetes as an effective active ingredient of insulin sensitizer, although the existing research reports have suggested that metformin can be used for endometriosis However, whether metformin disclosed in it can be used to treat and improve the endometrial receptivity of infertile patients with endometriosis by inhibiting the proliferation ability and apoptosis promotion ability of endometriosis cells is not given. Any associated research data and results. Therefore, in particular, the present invention actually relates to the applicat...

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Abstract

The invention discloses application of metformin in drugs for treating endometriosis, especially application of the metformin in drugs for treating endometriosis or drugs for improving the endometrialreceptivity of the endometriosis. By using the metformin which is currently used as the euglycemic agent, a novel efficient and safe treatment approach for solving the clinical difficulty of endometriosis infertility treatment is developed.

Description

technical field [0001] The invention belongs to the field of medical applications, in particular to the application of metformin in endometriosis drugs. Background technique [0002] Metformin, the chemical name is 1,1-dimethylbiguanide, and the chemical structural formula is: [0003] . [0004] Metformin has been used in clinical practice for 60 years. With its excellent sugar control efficacy and good drug safety, it has become the core drug for global diabetes control. Its role is mainly to reduce peripheral blood sugar concentration, increase the sensitivity of liver and peripheral tissues to insulin, inhibit liver gluconeogenesis, reduce blood lipids, promote microscopic protein dissolution and reduce platelet aggregation. In recent years, many research discoveries have been made on metformin, including its anti-tumor effect and anti-infection effect. At the same time, there have been many breakthroughs in the field of reproduction, among which metformin was found ...

Claims

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Application Information

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IPC IPC(8): A61K31/155A61P15/00
CPCA61K31/155A61P15/00
Inventor 黄薇肖丽刘冬刘畅李雪莹龙莹黄新
Owner THE WEST CHINA SECOND UNIV HOSPITAL OF SICHUAN
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