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Antibacterial modification method for high polymer material

A polymer material and modification technology, applied in the field of antibacterial modification, can solve problems such as patient infection and implant failure, and achieve the effect of preventing failure and improving surface properties

Inactive Publication Date: 2020-02-28
俞志焘
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In biomedical and engineering applications, bacterial adhesion to material surfaces and the subsequent formation of bacterial biofilms are serious problems, potentially leading to implant failure or patient infection

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] The present invention also proposes a method for antibacterial modification of polymer materials, comprising the following steps:

[0028] Preparation steps of diazomethane with hydroxyl groups;

[0029] Using diazomethane with thioether groups to chemically modify the surface of the polymer material;

[0030] And the step of using isobornyl acrylate to carry out Ag-S coordination reaction with the chemically modified polymer material.

[0031] Wherein, the preparation steps of the diazomethane with group are as follows:

[0032] Using benzoyl chloride and alcoholic hydroxyl as raw materials, it can be obtained through Friedel-Crafts reaction, hydrazone reaction and oxidation reaction.

[0033] Wherein, the preparation steps of the diazomethane with group are as follows:

[0034] Dissolve the alcoholic hydroxyl group in dichloromethane, then add benzoyl chloride dropwise, stir the reaction at room temperature after the dropwise addition, after the reaction, wash, rem...

Embodiment 2

[0043] The present invention also proposes a method for antibacterial modification of polymer materials, comprising the following steps:

[0044] Preparation steps of diazomethane with hydroxyl groups;

[0045] Using diazomethane with thioether groups to chemically modify the surface of the polymer material;

[0046] And the step of using isobornyl acrylate to carry out Ag-S coordination reaction with the chemically modified polymer material.

[0047] Wherein, the preparation steps of the diazomethane with group are as follows:

[0048] Using benzoyl chloride and alcoholic hydroxyl as raw materials, it can be obtained through Friedel-Crafts reaction, hydrazone reaction and oxidation reaction.

[0049] Wherein, the preparation steps of the diazomethane with group are as follows:

[0050] Dissolve the alcoholic hydroxyl group in dichloromethane, then add benzoyl chloride dropwise, stir the reaction at room temperature after the dropwise addition, after the reaction, wash, rem...

Embodiment 3

[0059] The present invention also proposes a method for antibacterial modification of polymer materials, comprising the following steps:

[0060] Preparation steps of diazomethane with hydroxyl groups;

[0061] Using diazomethane with thioether groups to chemically modify the surface of the polymer material;

[0062] And the step of using isobornyl acrylate to carry out Ag-S coordination reaction with the chemically modified polymer material.

[0063] Wherein, the preparation steps of the diazomethane with group are as follows:

[0064] Using benzoyl chloride and alcoholic hydroxyl as raw materials, it can be obtained through Friedel-Crafts reaction, hydrazone reaction and oxidation reaction.

[0065] Wherein, the preparation steps of the diazomethane with group are as follows:

[0066] Dissolve the alcoholic hydroxyl group in dichloromethane, then add benzoyl chloride dropwise, stir the reaction at room temperature after the dropwise addition, after the reaction, wash, remov...

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PUM

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Abstract

The invention discloses an antibacterial modification method for a high polymer material. The antibacterial modification method comprises the following steps: a step of preparation of diazomethane with a hydroxyl group; a step of chemical modification of the surface of the high polymer material with the diazomethane with a thioether group; and a step of an Ag-S coordination reaction of isobornyl acrylate and a chemically-modified high polymer material. According to the invention, the surface of the high polymer material is chemically modified by the diazomethane with the hydroxyl group, so thesurface performance of the high polymer material can be easily improved; meanwhile, environment-friendly isobornyl acrylate is used for modifying the high polymer material, and a good antibacterial layer is formed on the surface of the high polymer material, so a bacterial biofilm is prevented from being formed on the surface of the high polymer material, and the situations of implant failure andpatient infection are prevented from occurrence.

Description

technical field [0001] The invention relates to the related field of antibacterial modification technology, in particular to an antibacterial modification method of polymer materials. Background technique [0002] At present, the biggest problem with implantable / interventional medical polymer materials is that bacteria tend to adhere to the surface and form biofilms during clinical application, which can cause infection, surgery and medical accidents. According to preliminary statistics from the National Institutes of Health, 80% of bacterial diseases are related to medical materials. Bacterial biofilms commonly exist on artificial devices in the body, and have strong drug resistance and immune evasion. Even a drug that is hundreds of times the normal dose cannot be effectively removed, which often endangers the lives of patients. Taking the cardiovascular system as an example, the mortality rate due to infection of artificial devices is close to 100%. Therefore, obtaining...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J7/12C08L101/00
CPCC08J7/12C08J2300/00
Inventor 俞志焘
Owner 俞志焘
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