Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Preparation method of ozagrel impurity

A technology of impurity and mass ratio, applied in the field of preparation of ozagrel impurities, can solve the problems of appearance variation, activity reduction, low drug content and the like

Inactive Publication Date: 2020-03-06
深圳振强生物技术有限公司
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The impurities contained in the drug are the main factors affecting the purity of the drug. If the drug contains impurities exceeding the limit, it may change the physical and chemical constants, change the appearance, and affect the stability of the drug.
The increase of impurities will inevitably reduce the content of the drug or reduce the activity, and the toxic and side effects will increase significantly.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method of ozagrel impurity
  • Preparation method of ozagrel impurity

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0020] Further description will be made below in conjunction with the accompanying drawings and specific embodiments.

[0021] Such as figure 1 and figure 2 As shown, the present invention provides a kind of preparation method of ozagrel impurity, comprises the following steps:

[0022] S1: adding methyl 4-bromomethyl cinnamate and sodium methoxide in a mass ratio of 5:1 to an appropriate amount of methanol to prepare a solution;

[0023] S2: stirring at room temperature for 2-16 hours to fully react the mixture in the solution to obtain a mixed solution containing ozagrel impurities;

[0024] S3: Concentrating the ozagrel impurity by vacuum rotary evaporation;

[0025] S4: Purify the ozagrel impurity by column chromatography.

[0026] For making 4-bromomethyl cinnamic acid methyl ester dissolve completely, the content of methyl alcohol is as many as possible, present embodiment adds 1 part of 4-bromomethyl cinnamic acid methyl ester and 0.2 part of sodium methylate in 10...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a preparation method of a zagrel impurity. The method includes the steps of: adding methyl 4-bromomethylcinnamate and sodium methoxide into a proper amount of methanol according to a mass ratio of 5:1, and blending the substances into a dilute solution; performing stirring for 2-16h under a room temperature condition to enable full reaction of the mixture, thus obtaining amixed solution containing ozagrel impurity; concentrating the ozagrel impurity by vacuum rotary evaporation method; and carrying out purification treatment on the ozagrel impurity by column chromatography process. The method provided by the invention can simply and directly acquire an ozagrel impurity reference substance, also provides convenience for impurity analysis and research of ozagrel crude drugs and preparations thereof, and provides a detection method and judgment basis for production and medication safety of ozagrel.

Description

technical field [0001] The present invention relates to the technical field of drug impurity inspection and preparation, in particular to a method for preparing ozagrel impurities. Background technique [0002] Sodium ozagrel, chemical name (E)-3-[4-(1H-imidazol-1-methyl)yl]-2-sodium acrylate (1), is the first thromboxane synthase ( TX) inhibitors were put on the market under the trade name Cataclot by Japan Ono Pharmaceutical Co., Ltd. in 1989. Sodium ozagrel can hinder the production of thromboxane (TXA2) by the prostate (PGH2), and promote the conversion of PGH2 derived from platelets into endothelial cells, which are used to synthesize PGI2, thereby improving the abnormal balance between TXA2 and prostaglandin PGI2, and achieving the effect of inhibiting platelets. Aggregates and dilates blood vessels. Clinically, ozagrel sodium is mainly used for the treatment of acute thrombotic cerebral infarction and the movement disorder associated with cerebral infarction. [00...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C07C67/31C07C67/48C07C67/56C07C69/734
CPCC07C67/31C07C67/48C07C67/56C07C69/734
Inventor 李少龙
Owner 深圳振强生物技术有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com