44 results about "Impurity profiling" patented technology

The invention discloses an impurity analysis instrument for chemical detection, and relates to the technical field of chemical detection, the impurity analysis instrument comprises a machine body, the top of the machine body is fixedly provided with a discharging box, the machine body is internally provided with a mixing bin, a feeding pipe is fixedly connected between the discharging box and the mixing bin, and the machine body is fixedly provided with a first motor; a stirring rod is fixedly installed at the output end of the first motor, stirring blades provided with a large number of small holes are fixedly installed on the stirring rod, a discharging pipe is fixedly installed below the mixing bin and communicates with the interior of the mixing bin, and a plurality of detectors are fixedly installed at the positions, corresponding to the discharging pipe, in the machine body; and a detection head is fixedly installed at the input end of the detector and located in the discharging pipe, a filter screen is fixedly installed on the upper portion of the interior of the discharging pipe, and a collecting mechanism is arranged on the machine body and the mixing bin. According to the device, the effect of uniformly distributing impurities in a solution is achieved, the accuracy of a detection result is ensured, and meanwhile, metal products can be automatically collected.

The invention discloses an impurity analysis method for a budesonide inhalation solution, and relates to the technical field of budesonide impurity analysis, and the method comprises the following steps: weighing 50mg of a budesonide inhalation solution sample, placing the budesonide inhalation solution sample in a 10mL volumetric flask, adding a diluent (such as acetonitrile and methanol) to a scale line, and fully shaking to dissolve the diluent to prepare a 5mg / mL sample solution; and filtering the diluted sample by using a filter so as to remove insoluble impurities. According to the budesonide inhalation solution impurity analysis technology, the product quality, the market competitiveness and the research and development capability of enterprises can be remarkably improved, meanwhile, the requirements of laws and regulations are met, and time and cost are saved; by analyzing the impurities, the product quality and safety can be improved, and by accurately analyzing and controlling the impurity content in the medicine, the purity and quality of the product can be remarkably improved, so that the risk of adverse reaction and side effect can be reduced, and the medication safety of a patient is improved.

The invention provides an electronic-grade silicon-based material metal impurity online analysis system and method, and belongs to the field of impurity analysis. The electronic-grade silicon-based material metal impurity online analysis system comprises a sampling module used for collecting a target silicon-based material to obtain a silicon-based sample; the sample processing module is used for processing the silicon-based sample to obtain a first silicon-based sample; the sample analysis module is used for analyzing the first silicon-based sample to obtain an analysis result; the feedback control module is used for sending the analysis result to the terminal module; the sample processing module is respectively connected with the sampling module and the sample analysis module; and the sample analysis module is connected with the feedback control module. According to the invention, the detection speed and reliability of online analysis of the metal impurities of the silicon-based material can be improved.

The invention discloses a method for analyzing related substances and impurities in a reaction process of Mabazavir, relates to the field of medicine detection, and aims to provide a high-sensitivity and excellent-stability related substance analysis method for controlling the reaction process of Mabazavir, and the chromatographic conditions are as follows: a C18 chromatographic column (Waters Xselect CSH C18, 4.6 * 100mm, 3.5 mu m) of which the surface is charged and hybridized is adopted as a chromatographic column; a mobile phase A is a 0.05%-0.2% trifluoroacetic acid solution containing 0.1-1.0 mmol / L disodium ethylene diamine tetraacetate, a mobile phase B is acetonitrile, and isocratic elution is carried out according to the ratio of 55: 45; the column temperature is 40-60 DEG C; the flow velocity is 0.5 to 1.0 mL / min; the sample size is 5-20 [mu] l; and the operation time is 20-60 minutes. The method has the advantages of high detection sensitivity, good reproducibility, high stability and the like, and is suitable for detecting related substances controlled in the reaction process of the macavir.

The invention discloses a basic nickel carbonate impurity analysis method and system. The method comprises the following steps: judging whether each first identification result is an abnormal identification result or not; if a certain first recognition result is an abnormal recognition result, obtaining a certain target original image corresponding to the certain first recognition result, determining a certain position of the certain target original image in a certain original image sequence, and selecting other original images from other original image sequences according to the certain position; and inputting other original images into the image recognition model, outputting a second recognition result corresponding to other original images by the image recognition model, and performing basic nickel carbonate impurity analysis on a certain original image sequence and each original image in other original image sequences by adopting a preset impurity analysis strategy, and obtaining an analysis result of basic nickel carbonate on each production line. The efficiency of basic nickel carbonate impurity analysis in the whole production line can be effectively improved.

The utility model discloses an absorption system for silane gas metal impurity analysis. The absorption system comprises an impurity analysis pipeline, a sample tail gas emptying pipeline, a sample gas absorption device, a blank sample analysis pipeline, a purging tail gas emptying pipeline, a blank sample absorption device, a sample injection pipeline, a first purging gas inlet pipeline and a second purging gas inlet pipeline, the sample gas absorption device is connected with the gas outlet end of the impurity analysis pipeline and the gas inlet end of the sample tail gas emptying pipeline; the blank sample absorption device is connected with the gas outlet end of the blank sample analysis pipeline and the gas inlet end of the purging tail gas emptying pipeline; the gas outlet end of the sample injection pipeline and the gas outlet end of the first purge gas inlet pipeline are connected in parallel to the gas inlet end of the impurity analysis pipeline; and the gas outlet end of the second purge gas inlet pipeline is connected to the gas inlet end of the blank sample analysis pipeline. According to the utility model, a sample for silane gas metal impurity analysis and a blank control sample can be simultaneously obtained.

The invention discloses a method for detecting genotoxic impurities in dabigatran etexilate mesylate, and belongs to the technical field of pharmaceutical analysis. The detection method comprises the following steps: pretreatment of a sample: dissolving a dabigatran etexilate mesylate sample in an acid solution, extracting, then centrifuging the extract liquor, and taking supernate to respectively obtain to-be-detected solutions; the method comprises the following steps: pre-treating a genotoxic impurity standard substance according to a method which is the same as a method for pre-treating a dabigatran etexilate mesylate sample to obtain a standard solution; and measuring the standard solution and the to-be-measured solution by adopting a gas chromatograph-tandem mass spectrometer, and calculating according to the standard curve to obtain the content of each genotoxic impurity in the to-be-measured solution. According to the method, various genotoxic impurities and dabigatran etexilate mesylate are effectively separated through a liquid-liquid extraction method, the influence of dabigatran etexilate on genotoxic impurity analysis is reduced, interfering substances are reduced, and the method is high in accuracy and good in repeatability.

AI-Powered Computer for HPLC Data Analysis and Impurity Profiling

The invention relates to the field of oxide impurity analysis, in particular to a method and system for analyzing the content of impurities in oxide. The method comprises the following steps: setting oxide impurity samples, constructing a reference impurity database through the oxide impurity samples, and analyzing the reference impurity database to obtain a reference impurity data set; the method comprises the following steps: acquiring a to-be-detected spectrogram sequence of a to-be-detected oxide sample, analyzing the to-be-detected spectrogram sequence to obtain to-be-detected spectrogram subsequences, and constructing a to-be-detected spectrogram event chain; analyzing the spectrogram event chain to be detected to obtain a de-noised spectrogram event chain; analyzing the de-noised spectrogram event chain in combination with a reference impurity data set to obtain a matched impurity data set and an unmatched impurity data set of the to-be-detected oxide sample; and analyzing the matched impurity data set and the unmatched impurity data set to obtain an impurity analysis result of the to-be-detected oxide sample. According to the invention, the impurity identification precision can be improved.

This invention discloses an impurity analysis instrument for chemical testing, belonging to the field of chemical testing technology. It includes a main body, a feeding box fixedly installed on the top of the main body, a mixing chamber inside the main body, a feed pipe fixedly connected between the feeding box and the mixing chamber, a first motor fixedly installed on the main body, a stirring rod fixedly installed on the output end of the first motor, and stirring blades with numerous small holes fixedly installed on the stirring rod. A discharge pipe fixedly installed below the mixing chamber, communicating with the interior of the mixing chamber. Multiple detectors are fixedly installed inside the main body corresponding to the positions of the discharge pipe, with a detection head fixedly installed on the input end of each detector, located inside the discharge pipe. A filter screen is fixedly installed above the interior of the discharge pipe. A collection mechanism is provided on the main body and the mixing chamber. This invention achieves the effect of uniform distribution of impurities within the solution, ensuring the accuracy of the test results, while also automatically collecting metallic products.

This invention discloses a method and system for analyzing impurities in basic nickel carbonate. The method includes: determining whether each first identification result is an abnormal identification result; if a first identification result is an abnormal identification result, acquiring a target original image corresponding to the first identification result, determining a position of the target original image in a sequence of original images, selecting other original images from other sequences based on the position; inputting the other original images into an image recognition model, the image recognition model outputting a second identification result corresponding to the other original images, and using a preset impurity analysis strategy to perform basic nickel carbonate impurity analysis on each original image in the first and other sequences, obtaining the analysis results of basic nickel carbonate on each production line. This method can effectively improve the efficiency of basic nickel carbonate impurity analysis throughout the entire production line.

The application discloses a sample solution preparation method for trace impurity analysis of high-purity trimethylaluminum, and belongs to the technical field of trace impurity analysis, and the preparation steps are as follows: a magnetic stirring rotor is placed in a flue gas absorption bottle, nitric acid solution is added, and a magnetic stirring heater is started; high-purity trimethylaluminum is added into an oxidation decomposition bottle, a gas cylinder pressure reducing valve and an air inlet valve are opened, oxygen-nitrogen mixed gas in a gas cylinder is transported into the oxidation decomposition bottle, then an air outlet valve and an automatic one-way valve are opened, when there is no high-purity trimethylaluminum in the oxidation decomposition bottle, all the valves are closed, and a sample solution for trace impurity analysis of high-purity trimethylaluminum is obtained. The application adopts the method of oxidizing and decomposing trimethylaluminum by using high-purity oxygen-nitrogen mixed gas, and then nitric acid solution is used to dissolve aluminum oxide powder to prepare an aluminum ion nitric acid solution. The application has the advantages of single chemical variety, low concentration, no need for additional treatment of tail gas, simpler device structure, easy operation, low investment cost, safety, economy, and environmental protection.

The present application relates to the technical field of raw coal ash content regulation, in particular to a raw coal ash content feedforward automatic regulation system, comprising a coal sampling module, a sub-mine impurity detection module, a coal impurity analysis module, a washing parameter analysis module, a washing amount tracking module, an execution terminal and a cloud database. The physical and chemical detection of each sub-mine ensures the accuracy and scientificity of raw coal ash content detection, greatly improves the reliability of raw coal ash content detection results, and further provides strong data support for the analysis of subsequent washing operation parameters. By analyzing the washing parameters of raw coal mines, the washing effect of coal mines can be effectively optimized, achieving higher washing amount, improving the utilization value of coal mines, avoiding resource waste caused by unreasonable washing amount operation, and further improving the consistency and stability of washed clean coal.

The present invention discloses a method for determining the impurity content of recycled plastics, including sample pretreatment, sample detection, impurity analysis, and generating a quantitative estimation model. The method for determining the impurity content of recycled plastics of the present invention combines physical detection with chemical instrument detection, and can not only analyze and detect the apparent visible impurity content in the recycled plastics, but also analyze and detect the invisible impurity content. The present invention not only conducts a qualitative analysis of the impurity content in the recycled plastics, but also conducts a quantitative analysis, and can generally understand the impurity composition and content in the same recycled plastics. According to the impurity analysis results of the recycled plastics, an impurity quantitative estimation model can be generated to estimate the impurity content of the same recycled plastic samples.

A pretreatment method for the analysis of trace impurities in magnesium pyrocene involves placing a precisely weighed, dried sampling bottle and sampling device into an inert atmosphere chamber. Magnesium pyrocene is then placed into the sampling bottle using the sampling device, the bottle cap is tightened, and the inert atmosphere chamber is removed. The total weight of the sampling bottle and the magnesium pyrocene contained therein is accurately weighed. A 5% (w / w) dilute acid solution is then added dropwise to a Class 100 cleaning table to allow the reaction to proceed. After the reaction slows down, a small amount of the 5% (w / w) dilute acid solution is added to fully dissolve the sample. The solution is first heated at a low temperature, and the sample on the inner wall of the bottle is rinsed clean with the 5% (w / w) dilute acid solution. The temperature is then increased to allow for a complete reaction, and the acid is removed until nearly dry. The substance in the sampling bottle is then dissolved with the 5% (w / w) dilute acid solution to prepare the corresponding test solution for subsequent detection. This invention solves the problems of complex processes and the easy introduction of other trace impurities in existing technologies.

AI-BASED LABORATORY DEVICE FOR IMPURITY PROFILING OF HERBAL AND SYNTHETIC COMPOUNDS

The invention belongs to the field of radioactive substance treatment, and particularly relates to a radioactive sample pretreatment device and method for impurity analysis. The impurity analysis radioactive sample pretreatment device comprises an automatic weighing module, an automatic digestion module and an automatic nuclide separation module, and samples are bidirectionally transmitted among the modules. The automatic weighing module is used for carrying out code scanning, sample pouring and high-precision weighing on the samples; the automatic digestion module adopts a graphite heating mode to realize high-precision temperature control and accurate capacity determination; the automatic nuclide separation module uses a pipetting device to accurately add an activating solution so as to realize automatic operations of activation, leaching and elution. Through automatic operation, the manual operation error is reduced, the reliability of an impurity analysis result is ensured, and the working efficiency is improved.

This utility model relates to the technical field of textile testing equipment, and discloses a raw cotton impurity analyzer with self-cleaning function. The analyzer includes an analyzer with two conveyor wheels on its inner wall, two first fixing frames fixedly connected to its inner wall, multiple permanent magnets installed on the inner wall of an impurity collection funnel, a second fixing frame fixedly connected to the outer wall of the impurity collection funnel, a first spring on the outer wall of a fixing rod, a vibrating oscillator installed on the inner wall of the analyzer, a collection box slidably connected to the inner wall of the analyzer, and a shock-absorbing component at the bottom of the analyzer. In this utility model, multiple permanent magnets are installed at the bottom of the impurity collection funnel, within the inner wall of the second fixing frame, and the first spring is positioned between the two fixing rods, allowing the two fixing rods to slide against the inner wall of the analyzer, thus fixing the impurity collection funnel and facilitating its installation and removal.

The present application relates to the technical field of agricultural machinery, and provides a grain impurity analyzer, which comprises a screening mechanism, the screening mechanism comprises a vibrating device and a screening assembly in transmission connection with the vibrating device, the screening assembly eccentrically vibrates under the drive of the vibrating device, so that the grain to be analyzed in the screening assembly vibrates along a preset direction, and the preset direction is at least two directions; the screening assembly is provided with a feeding port, a first discharging port and a second discharging port; an impurity weighing device, the first discharging port is in communication with the feeding port of the impurity weighing device, so that the impurities screened out by the screening mechanism enter the impurity weighing device for weighing; and a clean grain weighing device, the second discharging port is in communication with the feeding port of the clean grain weighing device, so that the grain screened out by the screening mechanism enters the clean grain weighing device for weighing. The precision of impurity screening is improved, and the weighing accuracy is ensured.

The invention belongs to the technical field of material synthesis, analysis and detection, and provides a clofazimine impurity C, a salt and a preparation method thereof, and a clofazimine detection method. The invention provides a clofazimine impurity C and a salt thereof. The clofazimine impurity C has a structure as shown in a formula I. The applicant predicts the toxicity of the clofazimine impurity C through a Cramerrules model, and the result shows that the grade of the toxic harmful substance of the clofazimine impurity C is class III, and the clofazimine impurity C has significant toxicity or reactive functional groups. Meanwhile, according to the prediction of a Carcinogene model (IRFMN-ISSCAN-CGX) 1.2. 2 model, the impurity C of the clofazimine is a cancerogen, and three cancerogenic alarms exist. The clofazimine impurity C has potential genetic toxicity and carcinogenicity. The clofazimine impurity C and the salt thereof can provide convenience for impurity analysis and research of clofazimine bulk drugs and preparations thereof.

The invention discloses a method for detecting impurities in nitrosamine of vortioxetine hydrobromide by liquid chromatography-mass spectrometry. According to the method, an ultra-high performance liquid chromatograph-mass spectrometer is adopted, and octadecylsilane chemically bonded silica is used as a filler; the chromatographic conditions are as follows: the column temperature is 35-45 DEG C, the temperature of a sample introduction disc is 6-8 DEG C, the flow velocity is 0.3-0.5 ml / min, and the sample introduction amount is 2-20 microliters; and eluting with a gradient mobile phase. Mass spectrum conditions are as follows: a triple quadrupole tandem mass spectrometer is used for detection, an ion source is an electrospray ion source, and a positive ion scanning mode is adopted. Calculating the content of the impurity G by adopting an external standard method. The method for analyzing the impurity G in the vortioxetine hydrobromide, established by the invention, is strong in specificity, high in stability, high in accuracy, high in precision and strong in durability, and can be used as a method for detecting the content of the impurity G in the vortioxetine hydrobromide.

The invention relates to a cleanliness testing method. The method comprises the following steps: an impurity collection step (10): collecting impurity particles on a to-be-detected part on a first carrier made of a water-soluble material; a carrier dissolving step (20) of completely dissolving the first carrier and dispersing the impurity particles in an aqueous solution to form a particle solution when the first carrier together with the impurity particles collected thereon is placed in the aqueous solution; an impurity recollection step (30): collecting impurity particles in the particle solution by using a second carrier; and an impurity analysis step (40): detecting and analyzing the impurity particles on the second carrier. The method is particularly suitable for the application that an aerostatic press is adopted to collect impurity particles on a to-be-detected component onto a first carrier in a filter paper form and a microscope is adopted to detect and analyze impurity particles on a second carrier in a filter paper form. The component to be detected may be a fuel cell.

The invention provides a separation and purification method for degradation impurities in urea [13C] granules, and relates to the technical field of pharmaceutical analysis. The method comprises the following steps: carrying out an acid thermal degradation reaction on a urea [13C] granule sample by using a hydrochloric acid solution to obtain a degradation reaction solution; and carrying out liquid chromatography separation and purification on the degradation reaction liquid, and collecting a fraction rich in steviol-19-O-glucoside. And the fraction rich in steviol-19-O-glucoside can be efficiently and accurately obtained. According to the method, time-consuming and labor-consuming structural speculation and directional synthesis steps in traditional impurity analysis are avoided, the analysis cost is effectively reduced, the analysis period is effectively shortened, and meanwhile, the degradation impurity separation accuracy is improved.

The invention discloses an octafluoropropane crude product automatic sample injection and impurity analysis system and a use method thereof. The system comprises a color detector, two ten-way valves, two six-way switching valves and a thermal conductivity detector, a silica gel drying column is connected to a branch between a first pneumatic valve and a second pneumatic valve, and the other end of the silica gel drying column is connected with a sample inlet pipe; the detection range of the color detector covers the whole silica gel drying column, and the color detector is linked with the pneumatic valve; the first ten-way valve is respectively connected with a second twenty-way valve and a first six-way switching valve; the first six-way switching valve is further connected with a second twenty-way valve and a second six-way switching valve. And the second six-way switching valve is connected with the thermal conductivity detector. According to the invention, HF and F2 are prevented from corroding the chromatography, automatic continuous analysis of the octafluoropropane crude product is realized, detection equipment is effectively protected, and the service life of the equipment is prolonged; the impurities in the octafluoropropane are detected in groups, so that the analysis efficiency of an analysis sample is effectively improved, the analysis time is shortened to 30 minutes, and the ppm-level content impurity detection requirement is met.

The invention provides a pretreatment method for analyzing trace impurities in ferrocene. The method comprises the following steps: feeding a dry sampling bottle and a sampling device which are accurately weighed into an inert atmosphere operation box, taking a metal organic compound by using the sampling device, putting the metal organic compound into the sampling bottle, tightening a bottle cap of the sampling bottle, and taking out the inert atmosphere operation box; accurately weighing the total weight of the sampling bottle and ferrocene in the sampling bottle, dropwise adding a first preset amount of concentrated acid on a hundred-grade clean bench, heating to fully dissolve the concentrated acid, removing the acid until the concentrated acid is nearly dry, cooling, adding a second preset amount of concentrated acid along the bottle wall of the sampling bottle, heating, digesting, and removing the acid until the concentrated acid is nearly dry; and heating and dissolving by using a dilute acid solution with solute mass percentage of 5% to prepare a corresponding solution to be detected for detection. The concentrated acid is dropwise added to decompose the metal organic compound ferrocene to form soluble ferrocene, and the method has the advantages of easiness in operation, good safety, short detection time, no environmental pollution, good analysis result repeatability, wide applicability and the like.

The invention relates to the technical field of impurity protein detection, and particularly discloses a fluorescence low-cost detection-based oxytetracycline impurity protein content detection method, which comprises: S1, sample preparation, S2, fluorescence labeled antibody preparation, S3, standard curve preparation, S4, sample detection, and S5, result analysis. Specific detection of impurity protein in an oxytetracycline sample is achieved through the fluorescence labeled antibody, the result is consistent with the assumed concentration, and the method is high in sensitivity, high in specificity and suitable for accurate analysis and application in drug quality control; by adopting a fluorescence labeling technology and combining simple spectrograph detection, high use cost of a large instrument is avoided, the detection cost is reduced, meanwhile, the method has high sensitivity and accuracy, the reliability of a detection result is ensured, and the method is suitable for detecting the content of the oxytetracycline impurity protein and also suitable for detecting the content of the oxytetracycline impurity protein. And the method can be expanded to impurity analysis of other drugs and quantitative analysis of target proteins in biological samples, and has relatively high universality and practicability.

The invention belongs to the technical field of analysis and testing of impurities in high-purity samples, and particularly relates to an ICP-MS (Inductively Coupled Plasma Mass Spectrometry) detection method for trace impurities in high-purity yellow phosphorus. Through accurate weighing of a yellow phosphorus sample and a mixed acid-microwave digestion technology, the sample is rapidly dissolved under high-temperature and high-pressure conditions, and the sample is diluted and then directly detected on a machine; the yellow phosphorus sample pretreatment and on-machine measurement efficiency is improved. The method mainly comprises the following steps: S1, weighing a yellow phosphorus sample; s2, sample digestion; and S3, ICP-MS machine detection is carried out. According to the method, a yellow phosphorus sample is digested by adopting a mixed acid-microwave digestion method and then is detected by adopting an ICP-MS (Inductively Coupled Plasma Mass Spectrometry), and a proper amount of oxalic acid is added into the digested nitric acid, so that elements such as impurities As, Mg, Na, Ca and Fe in the yellow phosphorus sample can be effectively dissolved and released within a short time; in the detection process, a collision reaction tank mode is adopted to eliminate element interference, 23 trace impurity elements can be detected at the same time, the detection efficiency is high, the detection time of each batch of samples is shortened to be within 4 h, and the detection limit of each element is reduced to 10 ppt or below.

This invention proposes a method and system for improving the insulation resistance of ceramic capacitors, relating to the field of ceramic capacitor technology. The method involves acquiring capacitor usage scenario data, performing scenario determination analysis on the usage scenario data to obtain scenario determination analysis data, conducting ceramic material analysis based on the scenario determination analysis data to obtain ceramic material analysis data, performing ceramic structure dimension analysis and adjustment based on the ceramic material analysis data to obtain various analysis and adjustment data, performing joint dimension and impurity analysis based on the various analysis and adjustment data to obtain joint dimension and impurity analysis and adjustment data, and performing production process impurity analysis and adjustment based on the joint dimension and impurity analysis and adjustment data to obtain insulation resistance improvement data. This invention achieves multi-stage synergy and scenario-driven capability for improving insulation resistance.

The application provides a method for determining the content of impurity elements in concentrated isotopes based on HR-ICP-MS, and belongs to the technical field of element detection. The method provided by the application only needs to consume a small amount of concentrated isotope sample, and is particularly suitable for accurate analysis of the purity of high-value to-be-detected substances such as concentrated isotopes. In the application, the use of element mixed solution series standard substances can realize the simultaneous analysis of 68 kinds of impurity elements, which is significantly superior to the impurity analysis method based on the ICP-MS method in the prior art. The application utilizes an improved matrix effect correction method to realize the correction of the matrix effect through the measurement of the sensitivity factor under the to-be-detected matrix. The application designs a special sample measurement process, measures the process blank without the matrix by the external standard method, and measures the impurity content in the sample by matrix matching, so that the measurement result is more accurate.