Chip organ model for screening chemotherapy drugs for bladder tumor and preparation method thereof

Abstract

The invention discloses a chip organ model for screening bladder tumor chemotherapy drugs. The chip organ model comprises a surface modified plastic or glass base and a PDMS film, wherein the PDMS film is arranged on the top of the surface modified plastic or glass base; and one end of the PDMS film is provided with a liquid exchange tank outlet, and the other end of the PDMS film is provided witha liquid exchange tank outlet. The invention also discloses a manufacturing method of the chip organ model for screening bladder tumor chemotherapy drugs. The invention has the beneficial effects asfollows: the design of a microfluidic chip is further optimized by applying the PDMS film polymer breathable hydrophobic film, a special tissue culture chip is applied to high-throughput culture of invitro tumor tissues of individualized patients, and chemotherapy drugs are quickly and accurately screened through their reactions to different chemotherapy drugs in clinical practice, so as to improve the effective rate of drug therapy and reduce the treatment period of patients. According to the invention, the microfluidic chip technology is applied to the individualized treatment of bladder cancer, and the focus is on the screening of individualized chemotherapy drugs, which is helpful to improve the guidance of current clinical medication.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to an organ-on-a-chip model for screening chemotherapy drugs for bladder tumors and also relates to a method for making the organ-on-a-chip model. Background technique [0002] Bladder cancer is one of the most common urinary system tumors clinically in my country, and non-muscle-invasive bladder cancer accounts for 75% to 85% of all bladder tumors. Drug chemotherapy also plays an important role in the treatment of bladder cancer, especially perfusion chemotherapy after TURBT can effectively prevent tumor progression and reduce recurrence rate by eliminating residual lesions or carcinoma in situ and preventing deep tumor infiltration. [0003] At present, there are many drugs for bladder cancer chemotherapy in clinical practice, but the use of most drugs has no uniform clinical indications. The first-line regimen is still cisplatin-based chemotherapy, but currently ...

AI Technical Summary

Problems solved by technology

[0007] The purpose of the present invention is to provide an organ-on-a-chip model for screening chemotherapy drugs for bladder tumors and its manufacturing method, so as to solve the problems in improving the effectiveness of drug therapy proposed in the above-mentioned background technology, which is not conducive to reducing the treatment cycle of patients

Images