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Method for detecting Alzheimer's disease occurrence and severity products based on skin keratin fragments and content of keratin and application thereof

A technology for keratin fragments and Alzheimer's disease, which is applied in the direction of measuring devices, material excitation analysis, and material analysis through optical means, can solve non-invasive, fast, economical, non-invasive, non-invasive, Quick, economical methods, etc.

Inactive Publication Date: 2020-03-17
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] For Alzheimer's disease, there is no non-invasive, fast, economical method that can be used at home to determine whether the disease is present, and there is no non-invasive, fast, and economical method that can be used to screen out Alzheimer's patients during physical examination
At the same time, there is no non-invasive, fast, economical, and home-usable method for judging the prognosis of Alzheimer's disease. Therefore, inventing a non-invasive, fast, economical, and home-usable method for judging whether Alzheimer's disease is onset can be A non-invasive, rapid and economical method for screening out Alzheimer's disease patients during physical examination, as well as a non-invasive, rapid, economical method for judging the prognosis of Alzheimer's disease that can be used at home, has extremely important socioeconomic Significance and clinical value

Method used

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  • Method for detecting Alzheimer's disease occurrence and severity products based on skin keratin fragments and content of keratin and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Example 1: Determination of skin fluorescence mainly from keratin fragments.

[0023] Skin autofluorescent substances mainly include keratin, NAD, FAD, collagen, melanin, etc. Each phosphor has its own characteristic spectrum. We detected the spectrum of autofluorescence of human skin. The peak was found to be between 470nm-500nm. Based on this, we believe that the autofluorescence of the skin comes from keratin fragments.

Embodiment 2

[0024] Example 2: Confirmation of autofluorescent substances

[0025] In vivo experiment

[0026] The subject's surface keratin was imaged using a microscope. The excitation light used is blue light, and the specific wavelength range is between 470-500nm. The images of the distribution and content of keratin fragments on the body surface of the subjects were collected.

Embodiment 3

[0027] Example 3: Alzheimer's disease human population surface keratin fragments

[0028] Compared with healthy people, the skin keratin content of Alzheimer's patients is significantly increased. Such as figure 1 shown.

[0029] From the above experiments, it can be concluded that keratin fragments and keratin in the skin can be used as biomarkers. This marker can be used to judge the occurrence and severity of Alzheimer's disease.

[0030] The degree of elevated keratin fragments in the skin was positively correlated with the onset and severity of these Alzheimer's diseases, and the degree of decreased total keratin content was positively correlated with the occurrence and severity of Alzheimer's disease. The degree of elevated keratin fragments was positively correlated with the degree of poor prognosis of these Alzheimer's diseases, and the degree of decreased total keratin content was positively correlated with the degree of poor prognosis of Alzheimer's disease.

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Abstract

The invention provides a method for detecting Alzheimer's disease occurrence and severity products based on skin keratin fragments and the content of keratin and an application thereof. According to the application of keratin to a product for detecting occurrence and severity of Alzheimer's disease, occurrence, severity or the post-healing adverse degree of the Alzheimer's disease is judged by detecting the content of keratin fragments in the skin of a subject, the total content of keratin, related fluorescence or Raman spectra and other properties, the content of keratin is the sum of all keratin family proteins. Compared with people with non-Alzheimer's disease, keratin fragments in the skin of patients with Alzheimer's disease are increased, the total content of keratin is reduced, andautofluorescence images of the keratin fragments in the skin are changed.

Description

technical field [0001] The invention relates to a method for judging the occurrence and severity of Alzheimer's disease based on human skin keratin fragments, keratin content and left-right spatial distribution and its application. Background technique [0002] For Alzheimer's disease, there is no non-invasive, fast, economical method that can be used at home to determine whether the disease is present, and there is no non-invasive, fast, and economical method that can be used to screen out Alzheimer's patients during physical examination . At the same time, there is no non-invasive, fast, economical, and home-usable method for judging the prognosis of Alzheimer's disease. Therefore, inventing a non-invasive, fast, economical, and home-usable method for judging whether Alzheimer's disease is onset can be A non-invasive, rapid and economical method for screening out Alzheimer's disease patients during physical examination, as well as a non-invasive, rapid, economical method ...

Claims

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Application Information

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IPC IPC(8): G01N21/00G01N21/64G01N21/65
CPCG01N21/00G01N21/6486G01N21/65
Inventor 殷卫海张铭超陶钺吴丹红
Owner SHANGHAI JIAO TONG UNIV