Method for synthesizing nicotine salt by using micro-channel reactor under solvent-free condition

A micro-channel reactor and channel reactor technology, applied in the field of tobacco products, can solve the problems of failure to carry out continuous production, differences between batches, low efficiency, etc., and achieve high yield, stable state, and raw material cost. low effect

Inactive Publication Date: 2020-04-03
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The method does not allow for continuous production, is not efficient and has batch-to-batch variability

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Put liquid nicotine and acetic acid in a molar ratio of 1:1.1, add the syringe into the microchannel reaction chip, and stay at 25°C for about 85 seconds, and collect the prepared nicotine salt at the liquid connection port, and LC-MS is normalized The chemical yield is 56.25%.

[0015] MS (ESI + ):m / z:163([M-H]+).

Embodiment 2

[0017] Add liquid nicotine and acetic acid in a molar ratio of 1:1.2 to the syringe and pass it into the microchannel reaction chip, dwell at 75°C for about 129 seconds, collect the prepared nicotine salt at the liquid contact port, and normalize by LC-MS The yield was 32%.

[0018] MS (ESI + ):m / z:163([M-H]+).

Embodiment 3

[0020] Add liquid nicotine and acetic acid in a molar ratio of 1:1.3 to the syringe and pass it into the microchannel reaction chip, dwell at 75°C for about 95 seconds, and collect the prepared nicotine salt at the liquid connection port, LC-MS normalization The yield was 35%.

[0021] MS (ESI + ):m / z:163([M-H]+).

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PUM

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Abstract

The invention discloses a method for synthesizing nicotine salt by using a micro-channel reactor under a solvent-free condition. The method comprises the following steps: respectively adding liquid nicotine and acetic acid at a molar ratio of 1: (1.1-6) into an injector, pumping the liquid nicotine and acetic acid into the micro-channel reactor, heating to 25-95 DEG C to react for 85-706 seconds,and discharging through a liquid receiving port after the pressure of the system reaches a certain value, thereby obtaining nicotine salt. The method has the advantages of mild reaction conditions, simple operation, low raw material cost, no solvent addition, environmental protection, no post-treatment purification and high yield, and the prepared nicotine salt has the advantages of stable state,high purity, effective reduction of the irritation of nicotine, and suitableness for industrial production.

Description

Technical field: [0001] The invention relates to the field of tobacco products, in particular to a method for synthesizing nicotine salts under solvent-free conditions using a microchannel reactor. Background technique: [0002] Nicotine, commonly known as nicotine, has a molecular weight of 162.23, is a colorless or light yellow oily liquid at room temperature, is volatile, has a pungent odor, is optically active, and has two optical isomers. The alkaloids in plants (Solanum genus) are also important components of tobacco, and they are also representatives of N choline receptor agonists. They have effects on N1 and N2 receptors and the central nervous system, and have no clinical application value. [0003] Nicotine can be addictive or dependent, and repeated use of nicotine also increases heart rate and blood pressure and reduces appetite. Large doses of nicotine can cause vomiting and nausea, and in severe cases, people can die. Tobacco usually contains nicotine. E-cig...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D401/04C07C51/41C07C53/10
CPCC07C51/412C07D401/04C07C53/10
Inventor 黄漫娜邵李姝雯万一千
Owner SUN YAT SEN UNIV
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