Method for detecting illegally added prohibited components in sample with ultra-high efficiency

Abstract

The invention discloses a method for ultra-efficiently detecting illegally added prohibited components in a sample. The method comprises the following steps: retrieving a first-level MS1 characteristic spectrum and an MS2 second-level characteristic spectrum of related mental / toxic anesthetic related analytes in a database; the method comprises the following steps: establishing a corresponding qualitative database of poison, anesthesia and sperm, introducing a high-resolution mass spectrum into a sample by adopting a corresponding extraction method, acquiring mass spectrum data of the sample by virtue of UPLC, and matching a given database. The invention discloses a method for super-efficiently detecting illegally added prohibited components in a sample. A target analyte in a sample can beextracted to the greatest extent; the method can quickly and accurately determine whether the sample contains toxic, numb and refined components forbidden to be added, has the advantages of high sensitivity, high accuracy and short analysis time by adopting a high-resolution liquid chromatography-mass spectrometry method, and provides a quick verification basis for verification of unseen added parts in imported drugs and health care product customs imported drugs and drug smuggling inspection in a public safety system.

Description

technical field [0001] The invention relates to the technical field of drug detection, in particular to a qualitative test method for whether there are related prohibited ingredients in commercially available drugs or health products. Background technique [0002] The "Regulations on the Administration of Narcotic Drugs and Psychotropic Substances" stipulates detailed management regulations on the use and sale of narcotic drugs and psychotropic substances. The addition of related ingredients in drugs and health care products that enhance excitement is also a matter of concern. [0003] At present, the common content detection and analysis adopts HPLC method or LC / MS method to detect and quantify the content of related components. The measurement of this kind of analysis method is to select the target first for directional and quantitative detection, but because this type of analysis is various and related New types of "poison" substances emerge in an endless stream, which b...

AI Technical Summary

Problems solved by technology

[0003] At present, the common content detection analysis adopts HPLC method or LC / MS method to detect and quantify the content of related components. The measurement of this kind of analysis method is to select the target first for directional and quantitative detection. However, due to the variety of such analysis and the related The emergence of new "poison" substances has brought great challenges to the detection of such prohibited ingredients in conventional commercially available related drugs and health products, and it is impossible to quickly determine the prohibited ingredients in the sample in one sample. There is a risk of missed and wrong detections

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