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Cartilage graft scaffolds

A graft and cartilage technology, applied in medical science, tissue regeneration, prosthesis, etc., can solve the problems of long-term functional impact of grafts, poor matrix permeability, etc.

Inactive Publication Date: 2020-04-03
TRAUMA CARE CONSULT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Combined with the native 3D structure, this may counteract the formation of undesired cartilage types, thereby positively affecting the long-term function of the graft
[0007] Recolonization tests show that cells attach well to the surface of the decellularized scaffold, but show poor matrix permeability

Method used

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  • Cartilage graft scaffolds
  • Cartilage graft scaffolds
  • Cartilage graft scaffolds

Examples

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Embodiment

[0089] The following examples are presented to help the understanding of the present invention, but are not intended and should not be construed as limiting the scope of the present invention in any way. These examples do not include detailed descriptions of conventional methods. Such methods are known to those of ordinary skill in the art.

[0090] Materials and methods

[0091] Sample Collection

[0092] Macroscopically intact human articular cartilage was harvested from the femoral heads of donors undergoing hip replacement with patient consent and approval by the local ethics committee. Full-thickness non-calcified cartilage was isolated from the subchondral bone, prepared for biopsy with an 8 mm diameter biopsy punch, and washed with PBS + antibiotics (Pen / Strep). Cartilage biopsies were normalized to a full thickness or sample thickness of 300 μm using a Teixido cartilage cutter (Integra Life Sciences' United States). Cartilage is taken from the mid-section of the ...

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Abstract

The present invention relates to a biomaterial comprising a cartilage graft scaffold substantially free of viable cells, wherein the cartilage graft scaffold exhibits a plural of notches in form of lamellae or grids.

Description

[0001] describe technical field [0002] The present invention relates to cartilage graft scaffolds having engraved notches useful for therapeutic applications, and methods of making such scaffolds. Background technique [0003] Matrix-associated chondrocyte transplantation (MACT or MACI) is currently the gold standard for the treatment of large articular cartilage defects and improves symptoms in most patients. However, graft failure can still occur, and success is largely dependent on long-term postoperative physical therapy. Although donor age, body mass index, defect type, and surgical approach play a role, a significant cause of graft failure is inadequate post-implantation recovery or traumatic occurrence, both of which are related to early loading (Marlovits et al, Eur J Radiol, 2006, Jan;57(1):24-31), this can be prevented by reducing the time of loading of the load leading to the risk, or by making the implant less susceptible to infection, for example by a stiffer...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/36
CPCA61L27/3612A61L27/3683A61L2430/02A61L2430/06A61L2430/30A61L27/3654A61L27/56A61L27/3852A61L27/3834A61F2/30756A61F2/30771A61F2002/30827A61L27/3691A61L27/3804A61L27/3817A61L2430/40
Inventor H·雷德尔S·尼恩贝格尔J·策厄特纳
Owner TRAUMA CARE CONSULT
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