Gel comprising chlorhexidine

A technology of chlorhexidine, gel composition, applied in the field of oral hygiene, capable of solving the problems of damage, unavailability, non-functioning

Active Publication Date: 2020-04-10
实验室金公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For this reason, despite requests from dentists and surgeons, there are no gel compositions on the market that contain chlorhexidine and hyaluronic acid
[0016] On the other hand, some gels in which all desired components can be stably embedded together in a gelled matrix have a disadvantage, namely their adhesive properties on tissue poor or compromised, thus making it unusable
[0017] Additionally, many gelling agents are pH sensitive and do not perform their function at the final desired pH (for oral compositions, typically around 7-8) Function

Method used

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  • Gel comprising chlorhexidine
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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0126] Example 1. Aqueous Gel Formulations for Topical Use

[0127] Table 1 below shows a particular gel composition of the invention comprising chlorhexidine gluconate and sodium hyaluronate.

[0128] Table 1. Formulation of a colorless gel composition comprising 0.24% by weight of hyaluronic acid. Compositions are 100g and 5000g.

[0129]

[0130] This composition did not show any precipitation of chlorhexidine and / or hyaluronic acid.

[0131] Table 2 below shows the appearance and consistency of some gel compositions comprising chlorhexidine and hyaluronic acid. The presence of hydroxymethylcellulose provided a suitable gel consistency (colorless or white), but no precipitation was observed.

[0132] Table 2. Other gel compositions of the invention.

[0133]

[0134] Table 2 continued

[0135]

[0136] Table 2 continued

[0137]

[0138] Table 3. Formulation of a colorless gel composition comprising 1.0% by weight of hyaluronic acid. The composition is 10...

Embodiment 2

[0145] Example 2. Experiments for evaluating the mucoadhesive properties of topical products

[0146] The colorless gel of Example 1 (Table 1; gel composition containing 0.24% hyaluronic acid) was tested to assess mucoadhesive properties by gravimetric testing on an inclined temperature-controlled plane treated with mucin .

[0147] The purpose of this test is to evaluate the mucoadhesive properties of topical products by analyzing the kinetic detachment of samples from steel slopes with and without mucin biofilms. The actual mucoadhesiveness of the sample was determined by the slippage of the sample caused by the mucin and the delay in detachment from the plane.

[0148] Place the steel plane horizontally and set the temperature control 60 minutes in advance. Place 4ml of analytical sample or deionized water at the predetermined running distance and let stand for 2 minutes. To start the run, tilt the plane at 45°. The amount of sample detached from the plane falls into th...

Embodiment 3

[0167] Example 3. Clinical Trial of Efficacy of the Gel of the Invention Comprising Chlorhexidine and Hyaluronic Acid

[0168] The gel of Example 1 (Table 1) was tested to see if a gel with both active ingredients could be combined in dental practice after tooth extraction. The evolution of pain levels and inflammation after tooth extraction, as well as the degree of scarring (or degree of healing, which is used as a synonym for scarring) were assessed. The second aspect assessed included the ease of application and administration of the gel, its consistency and flavor and whether it had any effect on biofilm formation.

[0169] Materials and methods

[0170] A double-blind prospective clinical trial was conducted on 30 patients. The experimental group (or test group) consisted of 15 patients who received the gel of Example 1. The control group included another 15 patients who received a gel without hyaluronic acid and chlorhexidine as a placebo. Voluntary patients at the ...

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Abstract

The invention relates to a gel composition comprising chlorhexidine and/or a pharmaceutically acceptable salt thereof; hyaluronic acid and/or a pharmaceutically acceptable salt thereof; and a gellingmatrix, wherein the gelling matrix comprises water, and cellulose derivatives. The invention also relates to a method for preparing the gels and to particular uses of the gels in the field of oral cavity cosmetics, hygiene, prevention of oral cavity diseases and treatment of said diseases.

Description

[0001] This application claims the benefit of European Patent Application EP17382547.2 filed on 4th August 2017 and Irish Patent Application 2017 / 0230 filed on 2nd November 2017. technical field [0002] The present invention relates to the field of oral hygiene, and compositions having effective principles and ingredients to maintain oral health. Accordingly, the present invention relates to compositions useful in the field of dentistry or dental stomatology. Background technique [0003] According to the World Health Organization (WHO), oral health is the state of being free from a number of diseases that affect the oral cavity, including chronic oral and facial pain, cancer of the mouth and larynx, mouth ulcers, birth defects such as cleft lip and palate ), periodontal (gum) disease, tooth decay and tooth loss. Risk factors are unhealthy diet, smoking, harmful alcohol consumption and poor oral hygiene. It is well known that oral health contributes to overall health and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/41A61K8/43A61Q11/00A61K8/73A61Q19/00A61P1/02
CPCA61K8/41A61K8/43A61Q11/00A61K8/73A61Q19/00A61P1/02A61K8/416A61K8/731A61K8/735
Inventor J·巴拉施·里苏诺M·恩比德·洛佩兹
Owner 实验室金公司
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