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Preparation method of oropharyngeal hydrogel
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A hydrogel and gel matrix technology, applied in the field of medical devices, can solve problems such as affecting the quality of life of patients and long duration, and achieve the effects of good safety, reduced sensitivity and less adverse reactions
Pending Publication Date: 2020-04-28
LANJIATANG BIOLOGICAL MEDICINE FUJIAN CO LTD
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Problems solved by technology
[0004] Sore throat requires different treatment methods according to the cause, but generally lasts for a long time, which seriously affects the quality of life of patients
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Embodiment 1
[0039] Example 1 Preparation of oropharyngeal hydrogel I
[0040] Table 1 The dosage of oropharyngeal hydrogel Ⅰ
[0041]
[0042] Concrete preparation steps are (according to table 1 charging capacity):
[0043] (1) Weigh carbomer and fully swell with an appropriate amount of purified water as pre-solution 1.
[0045] (3) Weigh Tween-80 and propylene glycol, mix and stir evenly, add the menthol of the formula amount, stir until completely dissolved as pre-solution 3;
[0046] (4) Then add pre-solutions 2, 3, benzyl alcohol and triethanolamine to pre-solution 1 successively, stir, dissolve and mix;
[0047] (5) Then add the remaining amount of purified water, set the volume to 1000mL, and continue to stir for 10min to make the solution to a uniform state, a...
Embodiment 2
[0048] Example 2 Preparation of oropharyngeal hydrogel II
[0049] Table 2 The dosage of oropharyngeal hydrogel II
[0050]
[0051]
[0052]According to the dosage in Table 2, refer to the preparation method of Example 1 to prepare the oropharyngeal hydrogel II.
Embodiment 3
[0053] Example 3 Preparation of Oropharyngeal Hydrogel III
[0054] Table 3 The dosage of oropharyngeal hydrogel III
[0055]
[0056] According to the dosage in Table 3, refer to the preparation method of Example 1 to prepare the oropharyngeal hydrogel III.
[0057] The prepared oropharyngeal hydrogel was tested for its safety and effectiveness through the following tests.
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Abstract
The invention belongs to the field of medical instruments, and particularly relates to oropharyngeal hydrogel. The oropharyngeal hydrogel comprises gel substrates, citric acid, collagen, sodium hyaluronate, xylitol, silver ions, dipotassium glycyrrhizinate, benzyl alcohol, tween-80, propanediol, mint, yolk isolate and purified water. The invention also relates to a preparation method of the oropharyngeal hydrogel, and a purpose of the oropharyngeal hydrogel for preparing medical supplies for relieving the oral ulcer and / or swollen sore throat. The oropharyngeal hydrogel has the advantages thatthe safety is high; the oral ulcer can be effectively relieved; the level of inflammatory factors of TNF-alpha, IL-1 beta and IL-6 in ulcer positions can be slightly reduced; a good auxiliary effectis achieved on the treatment of the oral ulcer; particularly, the swollen sore throat caused by upper respiratory infection can be effectively relieved; and very good clinical application prospects are realized.
Description
technical field [0001] The invention belongs to the field of medical equipment, and in particular relates to an oropharyngeal hydrogel, a preparation method thereof and the use of a medical product for relieving oral ulcer and / or sore throat. Background technique [0002] Oral ulcer is a common oral mucosal disease, its etiology is complex, and there is no ideal treatment at present. When an oral ulcer occurs, the local burning pain is obvious, and many patients often have repeated symptoms, which affects normal diet and daily life, and even affects work or life emotions. [0003] Sore throat is a kind of modaldisease, and it is mainly in the cold season of the year, and cold, tonsillitis, sinusitis, whooping cough, pharyngitis and viral infection even myocardial infarction all can cause sore throat. [0004] Sore throat requires different treatment methods according to the etiology, but generally lasts for a long time, which seriously affects the quality of life of patien...
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