Application of rhizoma smilacis glabrae in preparing drug for promoting proliferation of CD4+ cells to assist therapy

Abstract

The invention discloses application of rhizoma smilacis glabrae in preparing a drug for promoting proliferation of CD4+ cells to assist therapy. Animal experiments prove that for the situation that the CD4+ cells obviously decrease after model building, CD4+ T cells obviously increase after water extract of the rhizoma smilacis glabrae or an extract thereof is applied, which shows that the rhizomasmilacis glabrae can be used for adjuvant therapy of diseases including the acquired immune deficiency syndrome, infectious mononucleosis, tuberculosis, tumors and the like caused by decrease of theCD4+ cells, and can be used for preparing the drug so as to perform adjuvant therapy of the diseases by promoting proliferation of the CD4+ cells. The rhizoma smilacis glabrae can enhance the immunityof a patient, and reduces the time and severity of infection, and the drug is safe and non-toxic, and is expected to be developed into the therapeutic drug for the acquired immune deficiency syndrome, the infectious mononucleosis, the tuberculosis, the tumors and the like.

Description

technical field [0001] The invention relates to a new medicinal use of traditional Chinese medicine Smilax smilax. Background technique [0002] CD4+ cells are an important part of human immunity. They can recognize MHC class II molecules and play a role in assisting in the recognition of TX-expressed antigen recognition receptors (TCR). CD4+ cells may promote the proliferation and differentiation of B cells, T cells and other immune cells, and coordinate the interaction between immune cells [Cao Xuetao, edited by He Wei, Medical Immunology, People's Health Publishing House, August 2015, third edition]. The reduction of CD4+ cells often leads to the weakening of immune function, such as in human immunodeficiency virus (human immunodeficiency virus) [0003] In the AIDS (acquired immunodeficiency syndrome, AIDS) caused by immunodeficiency virus (HIV), HIV mainly attacks CD4+ T cells, and CD4+ cells decrease, resulting in impaired immune function of the patient, and then infe...

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Problems solved by technology

[0005] 5654.2017.32.183, Luo Xiangqun, Zhao Quan, Xu Kui, etc. Clinical research on Jianpi Yiqi ointment combined with HAART to promote immune reconstitution in AIDS patients with poor immune reconstitution due to qi deficiency, Dazhong Science and Technology 2018, 20(228): 62), but currently lack of specific drugs

Smilax smilax is a traditional medicinal and edible material, and it is often used clinically to treat gout, nephritis, psoriasis, eczema, arthritis, hepatitis, tumor and other diseases (Yu Guangying, Liu Wei. Clinical application overview of Smilax smilax[ J].Journal of Liaoning University of Traditional Chinese Medicine, 2009(03):61~63), there is no literature report on the increase of CD4+ cells in Smilax smilax

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