Tri(2-methyl-2-phenylpropyl)tin 2-chlorothiophene-5-carboxylate complex, and preparation method and application thereof
A technology of phenylpropyl and chlorothiophene, which is applied in tin organic compounds, pharmaceutical formulations, chemical instruments and methods, etc., can solve problems such as application limitations and strong toxicity, and achieve simple preparation methods, low cost, and high anticancer activity Effect
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Embodiment 1
[0032]Preparation of tris(2-methyl-2-phenylpropyl)tin 2-chlorothiophene-5-carboxylate complex:
[0033] In a 250 mL round bottom flask, add bis[tris(2-methyl-2-phenylpropyl)]tin oxide 1.0534g (1.0mmol), 2-chlorothiophene-5-carboxylic acid 0.3258g (2.0 mmol), solvent toluene 25 mL, install a Dean-Stark trap, and heat under reflux at 112-120 °C for 6 h. After the reaction is completed, filter while it is hot, and remove the solvent from the filtrate with a rotary evaporator to obtain a white solid, which is recrystallized from ethanol, which is tris(2-methyl-2-phenylpropyl)tin 2-chlorothiophene-5-methanol ester complexes. Yield: 85%, melting point: 76-78°C.
[0034] Elemental analysis (C 35 h 41 ClO 2 SSn): Theoretical: C, 61.83; H, 6.08. Found: C, 61.88; H, 6.02.
[0035] IR(KBr, v / cm -1 ): 3728.40 (w), 2958.80 (m), 2920.23 (m), 2897.08 (w), 2860.43 (w), 2360.87 (s), 2337.72 (s), 1635.64 (m), 1537.27 (w), 1492.90 (w ), 1425.40 (m), 1338.60 (m), 1278.81 (w), 1188.15 (w)...
Embodiment 2
[0041] Preparation of tris(2-methyl-2-phenylpropyl)tin 2-chlorothiophene-5-carboxylate complex:
[0042] In a 250 mL round bottom flask, add bis[tris(2-methyl-2-phenylpropyl)]tin oxide 1.0536g (1.0 mmol), 2-chlorothiophene-5-carboxylic acid 0.3582g (2.2 mmol), solvent toluene 25 mL, install a Dean-Stark trap, and heat at reflux at 112-120 °C for 8 h. After the reaction is completed, filter while it is hot, and remove the solvent from the filtrate with a rotary evaporator to obtain a white solid, which is recrystallized from ethanol, which is tris(2-methyl-2-phenylpropyl)tin 2-chlorothiophene-5-methanol ester complexes. Yield: 82%, melting point: 76-78°C.
[0043] Elemental analysis (C 35 h 41 ClO 2 SSn): Theoretical: C, 61.83; H, 6.08. Found: C, 61.88; H, 6.02.
[0044] IR(KBr, v / cm -1 ): 3728.40 (w), 2958.80 (m), 2920.23 (m), 2897.08 (w), 2860.43 (w), 2360.87 (s), 2337.72 (s), 1635.64 (m), 1537.27 (w), 1492.90 (w ), 1425.40 (m), 1338.60 (m), 1278.81 (w), 1188.15 (w),...
Embodiment 3
[0050] Preparation of tris(2-methyl-2-phenylpropyl)tin 2-chlorothiophene-5-carboxylate complex:
[0051] In a 250 mL round bottom flask, add bis[tris(2-methyl-2-phenylpropyl)]tin oxide 1.0534 g (1.0 mmol), 2-chlorothiophene-5-carboxylic acid 0.3585 g (2.2 mmol), 35 mL of solvent toluene, installed a Dean-Stark trap, and heated to reflux at 112-120 °C for 8 h. After the reaction is completed, filter while it is hot, and remove the solvent from the filtrate with a rotary evaporator to obtain a white solid, which is recrystallized from ethanol, which is tris(2-methyl-2-phenylpropyl)tin 2-chlorothiophene-5-methanol ester complexes. Yield: 84%, melting point: 76-78°C.
[0052] Elemental analysis (C 35 h 41 ClO 2 SSn): Theoretical: C, 61.83; H, 6.08. Found: C, 61.88; H, 6.02.
[0053] IR(KBr, v / cm -1 ): 3728.40 (w), 2958.80 (m), 2920.23 (m), 2897.08 (w), 2860.43 (w), 2360.87 (s), 2337.72 (s), 1635.64 (m), 1537.27 (w), 1492.90 (w ), 1425.40 (m), 1338.60 (m), 1278.81 (w), 118...
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