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Application of valine in preparation of drug for treating or preventing infection of avian influenza virus

A technology of avian influenza virus and valine, which is applied in the field of biomedicine to achieve the effect of improving weight loss, increasing clearance ability, and reducing inflammatory damage

Active Publication Date: 2020-05-15
HUAZHONG AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] At present, most of the research on valine, lysine and isoleucine is based on nutrition and improving immunity, and there are few reports on the antiviral research of these amino acids

Method used

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  • Application of valine in preparation of drug for treating or preventing infection of avian influenza virus
  • Application of valine in preparation of drug for treating or preventing infection of avian influenza virus
  • Application of valine in preparation of drug for treating or preventing infection of avian influenza virus

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Effects of feeding valine, isoleucine and lysine on the body weight of mice infected with avian influenza virus:

[0028] The experimental animals were 8-week-old female C57BL / 6 specific pathogen-free (SPF) mice, a total of 40 were randomly divided into 4 groups, 10 in each group, and all animals were raised in a biosafety level 3 laboratory (ABSL3) .

[0029] The first group is the control group fed with sterile PBS; the second group is the group fed with valine solution; the third group is the group fed with isoleucine solution; the fourth group is the group with lysine solution.

[0030] The mice were fed with PBS, valine, isoleucine, and lysine solution every day. After one week, all mice were infected with 500 EID by intranasal drip 50After the H7N9 avian influenza virus was challenged, it was continued to be fed for 3 days, and the state of the mice was observed for 15 consecutive days after the infection of the influenza virus, and the body weight was measured, ...

Embodiment 2

[0043] Application of valine in the preparation of medicines for treating or preventing avian influenza virus infection:

[0044] The experimental animals were 8-week-old female C57BL / 6 specific pathogen-free (SPF) mice, a total of 20 were randomly divided into 2 groups, 10 in each group, and all animals were raised in a biosafety level 3 laboratory (ABSL3) . The first group is the control group fed with sterile PBS; the second group is the group fed with valine solution. The valine solution used and the dosage for gavage are the same as in Example 1.

[0045] The mice were fed with PBS or valine solution every day. One week later, all the mice were infected with 1 LD50 H7N9 avian influenza virus by intranasal drip, and continued to be fed for 3 days after the challenge. On day 5, the mice were dissected to take lung samples, 5 mice in each group. Add 1ml of sterile PBS (1mlPBS / lung) to the collected lung tissue samples, homogenize the homogenate, centrifuge to get the supe...

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Abstract

The invention relates to the field of biological preparations, and particularly discloses application of valine in preparation of a drug for treating or preventing infection of an avian influenza virus. Infected mice are treated by virtue of the valine in a lethal mouse flu infection model, so that the loss of the weight of the mice can be effectively improved, the survival rate of the mice can beeffectively increased, and the virus titer in supernate of lung tissues of the infected mice can be effectively decreased. Therefore, the valine disclosed by the invention is a new-found anti-influenza virus molecule, is essential amino acid in an animal body, has the advantages of high safety, convenience in use and the like, can be used for developing drugs for preventing or treating the infection of the influenza virus and has wide application prospects.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to the application of valine in the preparation of medicines for treating or preventing avian influenza virus infection. Background technique [0002] Influenza virus belongs to Orthomyxoviridae family Influenza virus, it is a kind of highly contagious infectious disease on a global scale, and viruses that threaten human health continue to appear repeatedly. In the world, the annual influenza epidemic will kill about 1 billion people. infection in humans, resulting in three to five million cases of severe illness and as many as one million deaths. Avian influenza virus belongs to Orthomyxoviridae Influenza A virus genus, the disease mainly occurs in poultry and wild poultry, which seriously hinders the development of poultry industry. At the same time, some of its subtypes (H5, H7, H9, H10) can also spread to humans across species, causing symptoms such as fever, co...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/198A61P31/16A61P29/00
CPCA61K31/198A61P31/16A61P29/00
Inventor 金梅林张强胡晓通杨丽王婷孙小美康超钟鸣
Owner HUAZHONG AGRI UNIV
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