Unlock instant, AI-driven research and patent intelligence for your innovation.

A kind of synthetic method of 3-azidotrisilane

A technology of azidotrisilane and synthesis method, which is applied in the direction of silicon organic compounds, chemical instruments and methods, compounds of group 4/14 elements of the periodic table, etc., and can solve the cumbersome preparation and reactivity of 3-halotrisilane Inconsistency and other issues, to achieve the effect of easy operation, good functional group tolerance, and wide applicability

Active Publication Date: 2022-06-03
YANGZHOU UNIV
View PDF3 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This reaction has the following disadvantages: the preparation of 3-halotrisilane is cumbersome, and the reactivity of chlorine, bromine and iodine is also inconsistent, and elimination reactions are prone to occur
This reaction also has many disadvantages: the preparation of epoxypropyl silane requires multiple reactions, and the ring-opened product has the selectivity problem of cis and trans

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of synthetic method of 3-azidotrisilane
  • A kind of synthetic method of 3-azidotrisilane
  • A kind of synthetic method of 3-azidotrisilane

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0027] General Procedure A: Synthesis of allyl azides. Its operation process is as follows:

[0028] To a stirred solution of HG-2 (2 mol%) in dichloromethane (1 mL / mmol) under argon was added alkene (1 eqiv) and allyl bromide (5 eqiv) dissolved in dichloromethane (2 mL / mmol) ) premixed solution and reacted at room temperature for 10 h. The dichloromethane solvent was removed to give crude allyl bromide. To the above solution of allyl bromide in anhydrous DMF (2 mL / mmol) and DMSO (1 mL / mmol) was added sodium azide (6eqiv) in portions and stirred at room temperature for 15h. After the reaction was completed, the resulting mixture was extracted with ethyl acetate and water, the aqueous layer was extracted three times, the combined organic layers were washed with saturated brine, the organic layer was dried over anhydrous sodium sulfate, filtered with suction and concentrated under reduced pressure. The corresponding allyl azide mixture was obtained by separation.

[0029] Th...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a synthesis method of 3-azidotrisilane. Firstly, allyl azide is synthesized by allyl bromide, because allyl azide is prone to [3,3] rearrangement at room temperature Reaction, so what is obtained is a mixture of a group of azides at both ends of the allyl group. Then, under the action of Karstedt's catalyst (0.25mol%), the organic solvent is used as the solvent, and dimethylphenylsilane (4 equiv) or other silane reagents are used as the silicon source to react selectively with the allyl azide mixture, utilizing terminal olefins and The difference in the rate of the hydrosilation reaction of intermediate olefins, combined with the [3,3] rearrangement reaction, can selectively obtain 3-azidotrisilane compounds.

Description

technical field [0001] The invention relates to the synthesis of compounds, in particular to a synthesis method of 3-azidotrisilane. Background technique [0002] As a chemical element, nitrogen is the most abundant element in the air, and it exists widely in nature, and many medicines contain nitrogen. Nitrogen-containing compounds also play a major role in living organisms, such as amino acids that make up proteins. In addition, nitrogen-containing compounds, such as drugs with amide structure, play a very good role in drug absorption, transport and metabolism due to their relatively stable physical and chemical properties. Organic azides are a kind of nitrogen-containing compounds that are widely used, and are also one of the main raw materials for the preparation of nitrogen-containing compounds. As a kind of organic azide compound, allyl azide compound is generally obtained as a mixture due to the [3,3] rearrangement in the molecule, which limits its application (J.Am...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): C07F7/08C07J1/00
CPCC07F7/0829C07J1/0059Y02P20/55
Inventor 刘汝章魏震王娟刘泳梅
Owner YANGZHOU UNIV