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Preparation method of adamantanol compound

An adamantanol and compound technology, which is applied in the field of the preparation of adamantanol compounds, can solve the problems of high price, inconvenient transportation and high production cost, and achieves the effects of simple operation, cheap raw materials and mild reaction conditions.

Inactive Publication Date: 2020-05-19
天津民祥药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method uses an excessive amount of resource material bromine, which is expensive and inconvenient to transport, resulting in higher production costs

Method used

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Examples

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Embodiment Construction

[0017] The present invention is further described below through specific examples, but the present invention is not limited to the following examples. Changes, combinations or substitutions made to the present invention within the scope of the present invention or without departing from the content, spirit and scope of the present invention are obvious to those skilled in the art and are included in the scope of the present invention Inside.

[0018] An adamantane alcohol compound preparation method, the preparation method comprises the following steps: adding quantitative adamantane, solvent and concentrated sulfuric acid into a three-neck flask equipped with a thermometer and a condensing reflux device, stirring and dissolving, slowly adding a quantitative oxidant, Then the reaction was stirred for a period of time at 80°C, the solvent was removed by distillation under reduced pressure, and the solution was neutralized with 30% sodium hydroxide solution; three different product...

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Abstract

The invention discloses a preparation method of an adamantanol compound. The preparation method comprises the following steps of: adding a certain amount of adamantane, a solvent and concentrated sulfuric acid into a three-neck flask provided with a thermometer and a reflux condensation device, stirring for dissolving, slowly adding a certain amount of an oxidant, stirring at 80 DEG C for reactingfor a period of time, performing reduced pressure distillation to remove the solvent, and neutralizing with a 30% sodium hydroxide solution. The process has the advantages of cheap and easily available raw materials, simple operation, mild reaction conditions and the like, and is suitable for industrial production.

Description

Technical field [0001] The invention relates to the field of preparation of adamantanol compounds, in particular to a preparation method of adamantaneol compounds. Background technique [0002] The adamantane alcohol compound obtained by bonding the hydroxyl group to the adamantane skeleton is a very important fine chemical product. It can be used to prepare photoresist monomers, photochromic compounds, pharmaceutical intermediates, etc., and is used in coatings, Adhesives, films, adsorption materials, etc. also have a wide range of uses. [0003] Regarding the preparation methods of adamantane alcohol compounds, the known methods mainly include bromination of adamantanes, and then hydrolysis at a high temperature under a certain pressure or hydrolysis with excess silver sulfate; for example, in the Chinese patent application with patent publication number CN101492348A, The adamantane is brominated and then hydrolyzed at a high temperature under a certain pressure to prepare 1-ada...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C29/48C07C35/37
CPCC07C29/48C07C2603/74
Inventor 刘万里李彬侯少利刘德宙
Owner 天津民祥药业有限公司