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Method for determining bisphenol compounds in food simulant

A technology of food simulants and bisphenols, which is applied in the direction of measuring devices, instruments, scientific instruments, etc., to achieve the effects of strong applicability, wide detection range, and accurate and reliable detection methods

Active Publication Date: 2020-05-26
GUANGZHOU QUALITY SUPERVISION & TESTING INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there is no report on the application of ultra-high performance liquid chromatography tandem mass spectrometry technology to the detection of migration of harmful substances in food contact materials to food simulants

Method used

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  • Method for determining bisphenol compounds in food simulant
  • Method for determining bisphenol compounds in food simulant
  • Method for determining bisphenol compounds in food simulant

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0062] This embodiment provides a method for detecting 14 kinds of bisphenol compounds in food simulants, and the operation steps are as follows:

[0063] 1 Experimental part

[0064] 1.1 Main instruments and devices

[0065] Thermo TSQ Quantuva ultra-high performance liquid chromatography-tandem mass spectrometer (Thermo Fisher, USA); high-speed refrigerated centrifuge (Allegra TM 64R, BECKMAN); ultrapure water system (Milli-Q, American Millipore Company); nitrogen blowing instrument (N-EVAP TM 111, U.S. Organomation Company); MS3 type vortex oscillator (IKA MS3, Germany Aika); analytical balance (BSA224S, Germany Sartorius); solid phase extraction device (Germany CNW company); Oasis HLB solid phase extraction column ( 200mg, 6mL, American Waters Company).

[0066] 1.2 Main materials and reagents

[0067] Standard or reference substance: BPA, BPF and TBBPA, purity ≥ 98.5%, products of Dr. Ehrenstorfer, Germany; BPB and BPS, purity ≥ 98%, products of American Acstandard ...

Embodiment 2

[0136] Embodiment 2, actual detection application

[0137] This method is used to test 100 food contact materials and products, and the product types involved include polycarbonate buckets, feeding bottles, water cups, food metal cans, food metal lids, etc. The test results showed that BPA migration was detected in 14 food metal lid samples, and BPF migration was detected in 1 food metal lid sample. The specific test results are shown in Table 6.

[0138] Table 6, positive sample detection result (%: volume ratio)

[0139]

[0140]

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Abstract

The invention relates to a method for determining a bisphenol compound in a food simulant, which comprises the following steps: precisely weighing the bisphenol compound, and dissolving the bisphenolcompound in an organic solvent to obtain a standard solution; preparing a to-be-detected solution, namely accurately measuring the food simulant after the food packaging material migrates the test sample, and taking the food simulant as the to-be-detected solution; and detection: respectively injecting the standard substance solution and the to-be-detected solution into a high performance liquid chromatography-tandem mass spectrometer for detection. According to the platform constructed by the scheme, one or more bisphenol compounds in 14 bisphenol compounds contained in the food simulant canbe detected; meanwhile, the method can also be suitable for one or more food simulants, the tedious operation that in the prior art, due to the fact that bisphenol compounds are large in structure andproperty difference, a detection scheme needs to be given for different phenolic compounds contained in specific types of food simulants is avoided, and the method has the advantages of being wide indetection range and high in applicability. And the method is accurate, reliable, rapid and sensitive.

Description

technical field [0001] The invention relates to the technical field of quality detection of food contact materials, in particular to a method for measuring bisphenol compounds in food simulants. Background technique [0002] Bisphenols are a class of compounds in which two hydroxyphenyl groups are connected by one or more carbon atoms, or other atoms such as sulfur atoms and oxygen atoms. The molecular structural formula of the bisphenol compound is represented by the following formula 1, wherein the middle connecting part R may have various structures, which may be one or more carbon atoms, such as -CH 2 -, -CH(CH 3 )-, -CH 2 (CH 2 )n-, etc., can also be a sulfur atom, such as -SO 2 -, can also be some other more complex structures. R 1 and R 2 Moieties can be hydrogen, halogen, alkyl, alkoxy, carboxyl, aromatic, and the like. [0003] [0004] Bisphenols are an important class of chemical products. The phenolic hydroxyl groups in bisphenol compounds are reactiv...

Claims

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Application Information

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IPC IPC(8): G01N30/88
CPCG01N30/88G01N2030/884
Inventor 李慧勇谭建华熊小婷王继才魏海峰陈意光夏泽敏李燕飞
Owner GUANGZHOU QUALITY SUPERVISION & TESTING INST
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