A green synthesis device for 4-chloroacetoacetates

Abstract

The invention discloses a green synthesis device for 4-chloroacetoacetate, which comprises a sealed heat-insulating shell, a conductive cylinder is arranged inside the heat-insulating shell, and the upper and lower ends of the conductive cylinder are connected with the inner cavity of the heat-insulating shell. The upper and lower sides are sealed and fixedly connected. An electrostatic generator is installed outside the insulation shell. The output end of the electrostatic generator is connected to the side of the conductive cylinder through a cable, and the cable runs through the insulation shell. The upper part of the inner cavity of the conductive cylinder is equipped with an electrostatic Sprayer, a precooler is installed on the outside of the conductive cylinder; this green synthesis device of 4-chloroacetoacetates electrostatically atomizes the diketene solution to increase the contact area between the diketene solution droplets and chlorine gas, and double The downward movement distance of the diketene solution droplet determines the reaction time of the diketene solution droplet and chlorine gas, the reaction time of diketene solution and chlorine gas is easy to control, reduces the generation of by-products, and avoids the loss of raw materials.

Description

technical field [0001] The invention relates to the technical field of organic synthesis equipment, in particular to a green synthesis device for 4-chloroacetoacetate. Background technique [0002] During the synthesis of 4-chloroacetoacetate esters: the diketene solution is at -15~-30°C, filled with chlorine gas, stirred at low temperature, after the reaction is completed, alcohols are added for esterification reaction, and after the reaction is completed, it is obtained by post-processing and rectification The yield of the product is 80-88%. If the contact time between chlorine gas and the product is too long, it is easy to produce other chlorinated compounds, such as: ethyl 2-chloroacetoacetate, ethyl 2,4-dichloroacetoacetate, 2 , 4 , 4-ethyl trichloroacetoacetate, etc., resulting in loss of raw materials. Contents of the invention [0003] The technical problem to be solved in the present invention is to overcome the existing defects and provide a green synthesis devi...

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Problems solved by technology

[0002] During the synthesis of 4-chloroacetoacetate esters: the diketene solution is at -15~-30°C, filled with chlorine gas, stirred at low temperature, after the reaction is completed, alcohols are added for esterification reaction, and after the reaction is completed, it is obtained by post-processing and rectification The yield of the product is 80-88%. If the contact time between chlorine gas and the product is too long, it is easy to produce other chlorinated compounds, such as: ethyl 2-chloroacetoacetate, ethyl 2,4-dichloroacetoacetate, 2 , 4 , Ethyl 4-trichloroacetoacetate, etc., causing loss of raw materials

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