Preparation method of boron-containing carbon quantum dots and application of boron-containing carbon quantum dots in tumor diagnosis and boron neutron capture therapy drugs

Abstract

The invention discloses a preparation method of boron-containing carbon quantum dots and an application of the boron-containing carbon quantum dots in tumor diagnosis and boron neutron capture therapydrugs, and relates to the field of chemical and biomedical tumor diagnosis and treatment. Glucose and BPA are used as raw materials to synthesize the boron-containing carbon quantum dots (BCDs), andthe quantum dots have in-vivo and in-vitro fluorescence luminescence properties similar to those of carbon quantum dots. Experiments prove that the BCDs synthesized by taking glucose and BPA can target brain tumors and other tumor tissues and are enriched at tumor parts, and the BCDs in healthy tissues can be quickly metabolized and excreted. The characteristic provides conditions for realizing excellent treatment effect of the BNCT. Therefore, the BCDs can be used as a novel tumor BNCT therapeutic agent, and integration of tumor diagnosis and BNCT treatment can be realized. The boron-containing carbon quantum dots are good in biocompatibility and have an excellent in-vivo fluorescence imaging effect.

Description

technical field [0001] The invention relates to the field of chemical and biomedical tumor diagnosis and treatment, in particular to the preparation of a boron-containing carbon quantum dot and its application in tumor diagnosis and boron neutron capture therapeutic drugs. Background technique [0002] The methods of biological disease diagnosis mainly include bioluminescence BL, fluorescence imaging FI, computed tomography CT, magnetic resonance imaging MRI, and photogenerated imaging PA technology. These technologies are of great significance for the diagnosis and follow-up treatment of tumors. Among the above diagnostic techniques, the X-rays produced by CT will cause certain damage to the organism, and the noise generated by MRI under the strong magnetic field will interfere with the organism to a certain extent. Compared with CT and MRI, FI is a quiet and non-destructive diagnostic technique, which can have better diagnostic results under certain conditions. Fluorescen...

AI Technical Summary

Problems solved by technology

BPA has a certain tumor affinity, but its water solubility is poor, so polyhydroxylated BPA(OH)x or combined with fructose are often used to improve its water solubility and bioavailability

Although BSH has good water solubility and high boron enrichment, it does not have tumor affinity and cannot target tumors

At the same time, when such boron-containing drugs are used for treatment, the accumulation and peak time of these drugs in tumor tissues cannot be monitored in a timely manner.

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