Preparation method of boron-containing carbon quantum dots and application of boron-containing carbon quantum dots in tumor diagnosis and boron neutron capture therapy drugs

A therapeutic drug and quantum dot technology, applied in the field of chemical and biomedical tumor diagnosis and treatment, can solve the problems of no tumor affinity, poor water solubility, inability to timely monitor enrichment and peak time, etc.

Active Publication Date: 2020-05-29
INST OF HIGH ENERGY PHYSICS CHINESE ACAD OF SCI
View PDF5 Cites 10 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

BPA has a certain tumor affinity, but its water solubility is poor, so polyhydroxylated BPA(OH)x or combined with fructose are often used to improve its water solubility and bioavailability
Although BSH has good water solubility and high boron enrichment, it does not have tumor affinity and cannot target tumors
At the same time, when such boron-containing drugs are used for treatment, the accumulation and peak time of these drugs in tumor tissues cannot be monitored in a timely manner.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method of boron-containing carbon quantum dots and application of boron-containing carbon quantum dots in tumor diagnosis and boron neutron capture therapy drugs
  • Preparation method of boron-containing carbon quantum dots and application of boron-containing carbon quantum dots in tumor diagnosis and boron neutron capture therapy drugs
  • Preparation method of boron-containing carbon quantum dots and application of boron-containing carbon quantum dots in tumor diagnosis and boron neutron capture therapy drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Synthetic steps:

[0048] Step 1. Using 5mmol of glucose (0.9g) and BPA (1.05g) as raw materials, add 2.5M (4mL) NaOH solution and mix and stir to fully mix and dissolve the glucose and BPA;

[0049] Step 2. Adjust the volume of the above-mentioned mixed solution to 30mL, then add the mixed solution of glucose and BPA into a 50mL reaction kettle, and react at 160 degrees for 6h to obtain a brown-black liquid;

[0050] Step 3: Filter the brownish-black liquid with a 0.22 μm filter membrane, and then purify by dialysis (500 Da molecular cut-off dialysis bag) for 24 hours. The obtained dialysis fluid was lyophilized to obtain a powdery product.

[0051] The present invention adopts simple and quick synthetic method such as figure 1 shown.

[0052] Synthetic nanomaterials, the synthetic particles are relatively uniform, with good monodispersity, and the particle size is about 2nm, such as figure 2 shown.

[0053] ICP-MS detected the B element content in the product, a...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
molar massaaaaaaaaaa
particle diameteraaaaaaaaaa
particle diameteraaaaaaaaaa
Login to view more

Abstract

The invention discloses a preparation method of boron-containing carbon quantum dots and an application of the boron-containing carbon quantum dots in tumor diagnosis and boron neutron capture therapydrugs, and relates to the field of chemical and biomedical tumor diagnosis and treatment. Glucose and BPA are used as raw materials to synthesize the boron-containing carbon quantum dots (BCDs), andthe quantum dots have in-vivo and in-vitro fluorescence luminescence properties similar to those of carbon quantum dots. Experiments prove that the BCDs synthesized by taking glucose and BPA can target brain tumors and other tumor tissues and are enriched at tumor parts, and the BCDs in healthy tissues can be quickly metabolized and excreted. The characteristic provides conditions for realizing excellent treatment effect of the BNCT. Therefore, the BCDs can be used as a novel tumor BNCT therapeutic agent, and integration of tumor diagnosis and BNCT treatment can be realized. The boron-containing carbon quantum dots are good in biocompatibility and have an excellent in-vivo fluorescence imaging effect.

Description

technical field [0001] The invention relates to the field of chemical and biomedical tumor diagnosis and treatment, in particular to the preparation of a boron-containing carbon quantum dot and its application in tumor diagnosis and boron neutron capture therapeutic drugs. Background technique [0002] The methods of biological disease diagnosis mainly include bioluminescence BL, fluorescence imaging FI, computed tomography CT, magnetic resonance imaging MRI, and photogenerated imaging PA technology. These technologies are of great significance for the diagnosis and follow-up treatment of tumors. Among the above diagnostic techniques, the X-rays produced by CT will cause certain damage to the organism, and the noise generated by MRI under the strong magnetic field will interfere with the organism to a certain extent. Compared with CT and MRI, FI is a quiet and non-destructive diagnostic technique, which can have better diagnostic results under certain conditions. Fluorescen...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): C01B32/15A61K41/00A61K49/00A61P35/00C09K11/65
CPCA61K41/0095A61K49/0019A61P35/00C09K11/65C01B32/15
Inventor 邢更妹李娟陈奎常亚男
Owner INST OF HIGH ENERGY PHYSICS CHINESE ACAD OF SCI
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap