Application of sea cucumber sterol sulfate in anti-atherosclerosis product

A technology of sea cucumber sterol sulfate and atherosclerosis, which is applied in the field of food nutrition and can solve the problems of no reports on the improvement of cardiovascular diseases

Inactive Publication Date: 2020-06-02
OCEAN UNIV OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, there is no report on the improvement effect of se...

Method used

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  • Application of sea cucumber sterol sulfate in anti-atherosclerosis product
  • Application of sea cucumber sterol sulfate in anti-atherosclerosis product
  • Application of sea cucumber sterol sulfate in anti-atherosclerosis product

Examples

Experimental program
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Effect test

Embodiment 1

[0034] Embodiment 1: the preparation of sea cucumber sterol sulfate

[0035] The structural formula of sea cucumber sterol sulfate is shown in figure 1 , the preparation process is as follows:

[0036] (1) After the body wall of North Atlantic ginseng is vacuum freeze-dried and pulverized, it is ground into powder (250 mesh);

[0037] (2) Take sea cucumber dry powder, add a certain volume of ethanol, keep the ratio of material to liquid at 1:10 (m / v), continue stirring and extracting at room temperature for 24 hours, obtain the extract, extract three times, and combine the extract The sea cucumber lipid crude extract was obtained by concentrating under reduced pressure;

[0038] (3) Weigh 200-300 mesh of silica gel, activate it at 110°C for 10 hours, and then cool it at room temperature; use dry method to pack the column, dissolve the silica gel with chloroform, remove the bubbles by ultrasonication, and put it into the column. After the silica gel has completely settled, us...

Embodiment 2

[0039] Embodiment 2: the preparation of sea cucumber sterol sulfate

[0040] (1) Grinding the sea cucumber body wall into powder (250 mesh) after vacuum freeze-drying and crushing;

[0041] (2) Take the above powder, add a certain volume of ethanol, keep the ratio of material to liquid at 1:12 (m / v), continue stirring and leaching for 24 hours at room temperature, obtain the leaching solution, leaching three times, and combine the leaching solution The sea cucumber lipid crude extract was obtained by concentrating under reduced pressure;

[0042] (3) Weigh 200-300 mesh silica gel, activate it at 110°C for 12 hours, and then cool it at room temperature; use dry method to pack the column, dissolve the silica gel with chloroform, remove the air bubbles by ultrasonic and put it into the column, and use 3 times the volume of silica gel after the silica gel has completely settled Chloroform presses the column to make the silica gel in the column more compact, and the air bubbles in...

Embodiment 3

[0044] Embodiment 3: the preparation of sea cucumber sterol sulfate

[0045] (1) Grinding the sea cucumber body wall into powder (250 mesh) after vacuum freeze-drying and crushing;

[0046] (2) Take the above powder, add a certain volume of ethanol, keep the ratio of material to liquid at 1:15 (m / v), and continue to stir and extract for 24 hours at room temperature to obtain the extract, extract three times, and combine the extract The sea cucumber lipid crude extract was obtained by concentrating under reduced pressure;

[0047] (3) Weigh 200-300 mesh silica gel, activate it at 110°C for 12 hours, and then cool it at room temperature; use dry method to pack the column, dissolve the silica gel with chloroform, remove the air bubbles by ultrasonic and put it into the column, and use 3 times the volume of silica gel after the silica gel has completely settled Chloroform presses the column to make the silica gel in the column more compact, and the air bubbles in the silica gel c...

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Abstract

The invention relates to the technical field of food nutrition, in particular to application of sea cucumber sterol sulfate in an anti-atherosclerosis product. The sea cucumber sterol sulfate is extracted and separated from sea cucumbers and subjected to microencapsulation, and experiments verify that the sea cucumber sterol sulfate and a microcapsule thereof have improvement functions on atherosclerosis. The sterol sulfate is prepared with the sea cucumbers as a raw material, experiments prove that the sea cucumber sterol sulfate can effectively reduce plaque areas of the atherosclerosis, that is, the sea cucumber sterol sulfate can remarkably inhibit the development of the atherosclerosis, indicating that the sea cucumber sterol sulfate can effectively prevent, improve or treat the atherosclerosis.

Description

Technical field: [0001] The invention relates to the technical field of food nutrition, in particular to the application of sea cucumber sterol sulfate in anti-atherosclerosis products. Background technique: [0002] Atherosclerosis is a disease of the large arteries, characterized by the accumulation of lipid and fibrous elements in the large arteries. With the improvement of people's living standards, the morbidity and mortality of cardiovascular and cerebrovascular diseases are increasing year by year. Epidemiological studies have revealed that atherosclerosis is considered a multifactorial disease. Sea cucumber, as a traditional medicinal and edible sea treasure in my country, has been proven to have a variety of nutritional effects. Sea cucumber sterol sulfate is a natural sterol substance in sea cucumber. Sea cucumber sterol sulfate and phytosterols are both structurally similar to cholesterol, but they function completely differently. High cholesterol level is a we...

Claims

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Application Information

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IPC IPC(8): A61K31/575A61K9/50A61K47/36A61P9/10C07J31/00A61K35/616A23L33/10
CPCA23V2002/00A61K9/5036A61K31/575A61K35/616A23L33/10A61P9/10C07J31/006A23V2200/326
Inventor 张恬恬薛长湖王玉明王腾李兆杰常耀光唐庆娟徐杰王静凤薛勇姜晓明
Owner OCEAN UNIV OF CHINA
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