Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

A kind of preparation method of coix seed oil nanocomposite particles

A technology of coix seed oil and composite granules, which is applied in the directions of non-active ingredients medical preparations, medical preparations containing active ingredients, drug combinations, etc., can solve the problem of in vivo resistance to digestion and target absorption, poor taste experience, and preparation Long time and other problems, to achieve the effect of improving digestion resistance and targeted absorption, low production cost, and reducing preparation time

Active Publication Date: 2022-03-29
FOSHAN UNIVERSITY
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to overcome the problems of high production cost, long preparation time, poor taste experience, weak resistance to digestion and targeted absorption in the existing production methods of coix seed oil nanoparticles, the primary purpose of the present invention is to provide a coix seed oil nanoparticle Preparation method of composite particles to reduce the raw material cost of coix seed oil oral nanoparticles and achieve better targeted absorption in vivo

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of preparation method of coix seed oil nanocomposite particles
  • A kind of preparation method of coix seed oil nanocomposite particles
  • A kind of preparation method of coix seed oil nanocomposite particles

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] A high-efficiency preparation method of coix seed oil nanocomposite particle carrier, comprising the following steps:

[0033] (1) Dispersing wheat gliadin (Gliadin) in 60% (V / V) ethanol solution, until the mass fraction of gliadin in the solution is 1%, until it is completely dissolved;

[0034] (2) Coix seed oil (CSO) was added at a mass ratio of 5:1 to prolamin, and magnetically stirred until the coix seed oil was completely dispersed and dissolved to obtain a dispersion;

[0035] (3) Pour the carboxymethyl chitosan (CMCS) solution into the vortex-stirred dispersion until the mass fraction of carboxymethyl chitosan in the dispersion is 0.5%, adjust the pH value to 4, stir for 10 min, and rotate Evaporate for 10min to remove ethanol;

[0036] (4) Add calcium ion solution until the mass fraction of calcium ion in the reaction system is 0.5%, stir for 10min,

[0037] Coix seed oil-prolamin-carboxymethyl chitosan-calcium ion colloid solution was prepared.

[0038] (5)...

Embodiment 2-5

[0040] Polysaccharide is carboxymethyl chitosan, and add-on is respectively 1mg (accounting for dispersion liquid mass fraction 0.1%) (embodiment 2), 2mg (accounting for dispersion liquid mass fraction 0.2%) (embodiment 3), 3mg (accounting for dispersion liquid mass fraction 0.2%) (embodiment 3), 3mg (accounting for dispersion liquid mass fraction 0.3% by mass fraction) (Example 4), 4 mg (accounting for 0.4% by mass fraction of the dispersion liquid) (Example 5), calcium ions accounted for 0.5% by mass fraction of the reaction system.

[0041] Other steps and raw materials are with embodiment 1.

[0042] The particle diameter (Size), surface potential (Zeta) and embedding efficiency (EE) of above embodiment gained nanoparticle are as follows figure 1 shown. It can be seen that the coix seed oil-prolamin-carboxymethyl chitosan nanoparticles obtained in each embodiment maintain good particle size and potential, and the embedding rate is >50%. When the mass fraction of carboxym...

Embodiment 6-11

[0044] Calcium ion is as cation, and its consumption is respectively 0mg (embodiment 6), 0.05mg (accounting for reaction system mass fraction is 0.05%) (embodiment 7), 0.1mg (accounting for reaction system mass fraction is 0.1%) (embodiment 8 ), 0.2mg (accounting for reaction system mass fraction is 0.2%) (embodiment 9), 0.3mg (accounting for reaction system mass fraction is 0.3%) (embodiment 10), 0.4mg (accounting for reaction system mass fraction is 0.4%) (Example 11). The mass fraction of carboxymethyl chitosan in the dispersion is 0.2%.

[0045] Other steps and raw materials are with embodiment 1.

[0046] The particle diameter (Size), surface potential (Zeta) and embedding efficiency (EE) of above embodiment gained nanoparticle are as follows figure 2 shown. It can be seen that the coix seed oil-prolamin-carboxymethyl chitosan nanoparticles obtained in each embodiment maintain good particle size and potential, and the embedding rate is >50%. When the mass fraction of...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle diameteraaaaaaaaaa
surface potentialaaaaaaaaaa
quality scoreaaaaaaaaaa
Login to View More

Abstract

The invention discloses a method for preparing coix seed oil composite granules. The method comprises the following steps: dissolving prolamin in an ethanol solution, adding coix seed oil to obtain a dispersion liquid, and then adding a polysaccharide solution to reach the mass of the polysaccharide in the dispersion liquid The fraction is 0.1-0.5%, the pH value is adjusted to 2-7, the ethanol is removed by rotary evaporation, and then the cation solution is added until the mass fraction of cations in the reaction system is 0.05-0.50%, and the coix seed oil nanocomposite particles are obtained by spray drying. The method of the present invention reduces the loss of the nanoparticle wall material, and the cation and the polysaccharide can further reduce the particle size of the nanoparticle through electrostatic crosslinking, forming a protective layer of the coix seed oil-prolamin, and the coix seed oil-prolamin enters the human body In the intestinal process, it can reduce the loss of gliadin wall material so that coix seed oil can reach the intestinal tract intact.

Description

technical field [0001] The invention relates to a method for preparing coix seed oil nanocomposite particles. Background technique [0002] Coix seed oil accounts for 2 to 7% of Coix seed, mainly containing coixenyl, coix lactone and sterol compounds, and unsaturated fatty acids are mainly oleic acid and linoleic acid, accounting for 85% of triglycerides. Coix seed oil has a good curative effect on anti-cancer and improving the body's immunity. It has been reported that routine oral administration of coix seed oil is safe, without skin irritation and rectal irritation, but its taste is poor, greasy, and poor absorption. The long-term clinical use of coix seed oil injection fat emulsion can reduce platelet Ⅲ / Level IV. [0003] Chinese patent application CN 104147436A discloses a coix seed oil oral nanoparticle and its preparation method. The composition of the method is as follows: 1 weight part of coix seed oil, 20 weight parts of polylactose glycolic acid polymer, 40 wei...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/42A61K36/8994A61K9/51A61K47/36A61P35/00A61P37/04
CPCA61K36/8994A61K9/5169A61K9/5161A61P35/00A61P37/04
Inventor 廖兰郑文宇杨彦红林维杰文晓燕周苏斌
Owner FOSHAN UNIVERSITY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com