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New application of small molecular compound SJB2-043 as medicine for inhibiting Marek's disease virus

A small molecule compound, Marek's technology, used in antiviral agents, drug combinations, medical preparations containing active ingredients, etc., to achieve the effect of wide application prospect, small dose and strong inhibitory effect

Active Publication Date: 2020-06-12
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far there are no reports of SJB2-043 inhibiting Marek's virus activity or any antiviral activity

Method used

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  • New application of small molecular compound SJB2-043 as medicine for inhibiting Marek's disease virus
  • New application of small molecular compound SJB2-043 as medicine for inhibiting Marek's disease virus
  • New application of small molecular compound SJB2-043 as medicine for inhibiting Marek's disease virus

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] CEF cell preparation and virus infection:

[0034] 1. Take 9-11 day-old SPF chicken embryos, wipe and disinfect them from the center of the chicken embryos to the surrounding areas with iodine wine and alcohol cotton respectively, and then put them into the ultra-clean table, with the parts with air cells facing upwards, carefully use sterile tweezers Crack the eggshell and clip off the eggshell along the edge of the air chamber, taking care not to let the eggshell debris fall into the egg.

[0035] 2. Replace the allantoic chorion with new sterile tweezers, and then use the elbow tweezers to penetrate into the embryo to clamp the neck of the chicken embryo and take it out, put it into a disposable plate, and remove the head and limbs of the chicken embryo.

[0036] 3. Transfer to a small beaker and digest with 6% trypsin in batches. When the solution is turbid, filter the cells with a 70 μm filter, transfer to a centrifuge tube, and add medium to the centrifuge tube to...

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PUM

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Abstract

The invention relates to the field of new application of compounds, and relates to the field of medicine, in particular to a new application of a small molecular compound SJB2-043 as a medicine for inhibiting Marek's disease virus. According to CEF cell preparation and culture, drug toxicity experiments, inhibition of virus plaques, Q-PCR verification of virus copy number and preliminary animal experiments, the compound SJB2-043 can effectively inhibit replication of Marek's disease viruses at a safe concentration, and the compound SJB2-043 can be used for preparing anti-Marek's disease drugs,muscular hemorrhage, neurological symptoms and animal tumors of toxicity attacking experimental animals are generated, and the product has a good application prospect in poultry breeding.

Description

technical field [0001] The invention relates to the field of new applications of compounds, in particular to the new application of small molecular compound SJB2-043 as a drug for inhibiting Marek's virus. Background technique [0002] Marek's disease (MD) is a highly contagious, highly pathogenic, malignant neoplastic disease induced by Marek's virus (MDV), which can cause high morbidity and mortality in chicken flocks. One of the three major diseases of the poultry industry. According to the statistics of the Food and Agriculture Organization (FAO), the poultry industry in the world loses at least 2 billion US dollars every year due to MD. According to the statistics of the World Organization for Animal Health (OIE), MD occurs in every poultry-raising country in the world, and my country and Egypt belong to areas with high incidence. my country is a big country in the production of poultry eggs and poultry meat in the world, ranking first and second respectively in the w...

Claims

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Application Information

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IPC IPC(8): A61K31/423A61P31/22A61P35/00A61P21/00A61P7/04A61P25/00
CPCA61K31/423A61P7/04A61P21/00A61P25/00A61P31/22A61P35/00
Inventor 艾永兴林俊彦许家翠谢知航周宏达王梦涵王梦云周小露周文杰周正轩吕岩
Owner JILIN UNIV
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