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An anti-acne composition containing lipase inhibitor and vegetable oil

A technology of lipase inhibitor and composition, applied in the field of medicine

Inactive Publication Date: 2020-06-16
ZHONGSHAN WANHAN PHARM CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In summary, the anti-Propionibacterium acnes activity of the lipase inhibitor and the vegetable oil needs to be further improved

Method used

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  • An anti-acne composition containing lipase inhibitor and vegetable oil
  • An anti-acne composition containing lipase inhibitor and vegetable oil
  • An anti-acne composition containing lipase inhibitor and vegetable oil

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0062] Embodiment 1 The preparation of the external suspension that contains the composition of lipase inhibitor and vegetable oil

[0063] [Prescription] Compound II 9.88g, mint leaf oil 0.12g, camphor distiller 250mL, sodium carboxymethylcellulose 5g, glycerin 100g, add purified water to 1000mL.

[0064] [Preparation] Take Compound II in a mortar, add glycerin and grind it into a fine paste. In addition, use 200mL of water to make carboxymethyl cellulose sodium into a slurry, slowly add it into the mortar under stirring, move it into a measuring device, add camphor spirit and mint leaf oil in a small stream while stirring, add purified water to the full amount, Stir well and serve.

Embodiment 2

[0065] Embodiment 2 Preparation of the external emulsion containing the composition of lipase inhibitor and vegetable oil

[0066] [Prescription] Compound Ⅰ 0.38g, Italian chrysanthemum flower oil 9.62g, Arabic gum fine powder 125g, tragacanth gum fine powder 7g, sodium saccharin 0.1g, volatile almond oil 1mL, ethylparaben 0.5g, purified water to 1000mL.

[0067] [Preparation] Grind compound Ⅰ, Italian chrysanthemum flower oil and gum arabic evenly, add 250mL of purified water at a time, grind vigorously in one direction to make colostrum, add aqueous solution of sodium saccharin, volatile almond oil, ethylparaben alcohol solution, and slowly Slowly add the tragacanth gum glue, add purified water to the full amount, stir well, and you have it.

Embodiment 3

[0068] Embodiment 3 The preparation of the ointment containing the composition of lipase inhibitor and vegetable oil

[0069] [Prescription] Compound Ⅰ 5.00g, thyme flower oil 5.00g, stearic acid 12.5g, glyceryl monostearate 17.0g, beeswax 5.0g, white petrolatum 67.0g, aluminum distearate 10.0g, ozokerite 75.0g , liquid paraffin 410.0mL, ethylparaben 1.0g, calcium hydroxide 1.0g, add distilled water to 1000g.

[0070] [Preparation method] Take compound Ⅰ, thyme flower oil, stearic acid, glyceryl monostearate, beeswax, ozokerite, heat and melt on a water bath, then add liquid paraffin, white petrolatum, aluminum distearate, and heat to 85°C (oil phase); in addition, dissolve calcium hydroxide and ethylparaben in distilled water and heat to the same temperature (water phase); slowly add the water phase to the oil phase under stirring until it condenses, that is have to.

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Abstract

The invention provides an anti-acne composition containing a lipase inhibitor and vegetable oil. The definitions of the lipase inhibitor and the vegetable oil are shown in the specification. An in-vitro test result shows that the composition of the lipase inhibitor and the vegetable oil can generate a synergistic antibacterial effect on clindamycin drug-resistant propionibacterium acnes (the combined medication index CI (1)), and an animal test further verifies the synergistic anti-acne effect.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to an anti-acne composition containing a lipase inhibitor and vegetable oil. Background technique [0002] Acne is a chronic inflammatory skin disease of the pilosebaceous unit that occurs during adolescence and mainly affects the face. The incidence of acne in the Chinese population is 8.1%. However, studies have found that more than 95% of people will have different degrees of acne, and 3% to 7% of acne patients will leave scars, which will have a great impact on the physical and mental health of patients. The pathogenesis of acne is still not fully elucidated. Under the genetic background, hormone-induced excessive secretion of sebaceous glands, abnormal keratinization of pilosebaceous gland ducts, proliferation of hair follicle microorganisms such as Propionibacterium acnes, and inflammation and immune responses are related to it. [0003] Yan Sinan, a 2014 gradua...

Claims

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Application Information

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IPC IPC(8): A61K45/06A61K31/365A61K31/536A61K36/534A61K36/287A61K36/53A61K36/47A61K47/44A61P17/10A61P31/04
CPCA61K31/365A61K31/536A61K36/287A61K36/47A61K36/53A61K36/534A61K45/06A61K47/44A61P17/10A61P31/04A61K2300/00
Inventor 向飞杜志博苏海娟李玲杨衍秋彭韪
Owner ZHONGSHAN WANHAN PHARM CO LTD