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Anti-acne composition containing lipase inhibitor and alcohol compound

A technology of lipase inhibitors and compounds, applied in the field of medicine

Inactive Publication Date: 2020-06-19
ZHONGSHAN WANHAN PHARM CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In summary, the anti-Propionibacterium acnes activity of lipase inhibitors and alcohol compounds needs to be further improved

Method used

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  • Anti-acne composition containing lipase inhibitor and alcohol compound
  • Anti-acne composition containing lipase inhibitor and alcohol compound
  • Anti-acne composition containing lipase inhibitor and alcohol compound

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] Example 1 Preparation of the External Suspension Containing the Composition of Lipase Inhibitor and Alcohol Compound

[0049] [Prescription] Compound II 0.20g, camphor alcohol 9.80g, camphor spirit 250mL, sodium carboxymethylcellulose 5g, glycerin 100g, add purified water to 1000mL.

[0050] [Preparation] Take Compound II in a mortar, add glycerin and grind it into a fine paste. In addition, use 200mL of water to make carboxymethyl cellulose sodium into a slurry, slowly add it into the mortar under stirring, move it into a measuring device, add camphor spirit and camphor non-alcohol in a small stream while stirring, add purified water to the full amount, Stir well and serve.

Embodiment 2

[0051] Example 2 Preparation of the External Emulsion Containing the Composition of Lipase Inhibitor and Alcohol Compound

[0052] [Prescription] Compound Ⅰ 2.40g, C12-15 alcohol 7.60g, Arabic gum powder 125g, tragacanth gum powder 7g, sodium saccharin 0.1g, volatile almond oil 1mL, ethylparaben 0.5g, purified water to 1000mL.

[0053] [Preparation] Compound Ⅰ, C12-15 alcohol and Arabidopsis, and then add 250mL of purified water at a time, grind vigorously in one direction to make colostrum, add saccharin sodium aqueous solution, volatile almond oil, ethylparaben alcohol solution, and slowly Slowly add the tragacanth gum glue, add purified water to the full amount, stir well, and you have it.

Embodiment 3

[0054] Example 3 Preparation of Ointment Containing the Composition of Lipase Inhibitor and Alcohol Compound

[0055] [Prescription] Compound II 9.88g, 1,2-pentanediol 0.12g, stearic acid 12.5g, glyceryl monostearate 17.0g, beeswax 5.0g, white petrolatum 67.0g, aluminum distearate 10.0g, Ozone wax 75.0g, liquid paraffin 410.0mL, ethylparaben 1.0g, calcium hydroxide 1.0g, add distilled water to 1000g.

[0056] [Preparation method] Take compound II, 1,2-pentanediol, stearic acid, glyceryl monostearate, beeswax, ozokerite, heat and melt on a water bath, then add liquid paraffin, white petrolatum, and distearic acid aluminum, heated to 85°C (oil phase); in addition, dissolve calcium hydroxide and ethylparaben in distilled water, and heat to the same temperature (water phase); slowly add the water phase to the oil phase while stirring, Until it condenses, that is.

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Abstract

The invention provides an anti-acne composition containing a lipase inhibitor and an alcohol compound. The definitions of the lipase inhibitor and the alcohol compound are shown in the specification.In-vitro test results show that the composition containing the lipase inhibitor and the alcohol compound can generate a synergistic antibacterial effect on clindamycin-resistant propionibacterium acnes (drug combination index CI(1)), and the animal tests further verify the synergistic antibacterial effect.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to an anti-acne composition containing lipase inhibitors and alcohol compounds. Background technique [0002] Acne is a chronic inflammatory skin disease of the pilosebaceous unit that occurs during adolescence and mainly affects the face. The incidence of acne in the Chinese population is 8.1%. However, studies have found that more than 95% of people will have different degrees of acne, and 3% to 7% of acne patients will leave scars, which will have a great impact on the physical and mental health of patients. The pathogenesis of acne is still not fully elucidated. Under the genetic background, hormone-induced excessive secretion of sebaceous glands, abnormal keratinization of pilosebaceous gland ducts, proliferation of hair follicle microorganisms such as Propionibacterium acnes, and inflammation and immune responses are related to it. [0003] Yan Sinan, a 2014 gr...

Claims

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Application Information

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IPC IPC(8): A61K31/337A61K31/536A61K45/06A61P17/10A61P31/04
CPCA61K9/0014A61K31/337A61K31/536A61K45/06A61P17/10A61P31/04
Inventor 向飞杜志博苏海娟李玲杨衍秋彭韪
Owner ZHONGSHAN WANHAN PHARM CO LTD