Novel polycyclic compound
A polycyclic compound, compound technology, applied in the directions of organic chemistry, chemical instruments and methods, methine/polymethine dyes, etc., can solve problems such as unfavorable industrial utilization, and achieve the effect of protecting human body
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Embodiment 1
[0146] Preparation of 2-(2-hydroxy-3-(chloromethyl)-5-methyl)benzotriazole (compound 3)
[0147]
[0148] Add 2-(2-hydroxyl-5-methyl)benzotriazole (UV-P, compound 3) 350g, paraformaldehyde 55g, acetic acid 2000g, 35% hydrochloric acid 300g in 5000ml reaction flask, heat up to 60 The temperature was kept at ℃ for 10 hours, and samples were taken to monitor the reaction. Lower the temperature, wash with water, and dry to obtain a white powder (chloromethyl UV-P, compound 4), with a yield of 96%. C 14 h 12 ClN 3 O, melting point: 163-164°C.
Embodiment 2
[0150] Preparation of 2-(2-hydroxy-3-(N,N-dimethylaniline)-5-methyl)benzotriazole (compound 5)
[0151]
[0152] Add 180ml of toluene, 17g of potassium carbonate, 13.9g of N-methylaniline, 0.2g of phase catalyst, and 33.3g of compound (4), heat up to 90-100°C for 5 hours, and monitor the reaction by sampling. Cool down to 30°C, wash with water and recover toluene. Add 180g of methanol and stir, filter and dry to obtain a solid (compound 5). The purity is 98.3%, and the yield is 84%. C 21 h 20 N 4 O, melting point: 98-100°C.
Embodiment 3
[0154] Preparation of 2-(2-hydroxy-3-(4-formyl-N,N-dimethylaminophenyl)-5-methyl)benzotriazole (Compound 6)
[0155]
[0156] Put in 35g of compound (5) and 8.7g of DMF, and add 18.4g of phosphorus oxychloride dropwise at 20-25°C, and the addition is completed in about 2 hours. The temperature was raised to 90° C. for 2 hours, and samples were taken to monitor the reaction (Vilsmeier-Haack formylation). Slowly add the reaction material to 300g of water below 30°C for hydrolysis, then neutralize with 30% liquid caustic soda, adjust the pH to 8, and filter out the solid. Dissolve in toluene, wash with water, cool down to 15°C, solid precipitates, and dry to obtain 31.8g of yellow solid (compound 6). C 21 h 19 N 4 o 2 , Melting point: 111-113°C.
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