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Production process for belladonna herb extract

A production process and technology for belladonna extract, applied in the field of production technology of belladonna extract, can solve the problems of affecting the color and shape of the extract, low content of active ingredients, reducing the medicinal efficacy of the extract, etc., so as to improve the purity of the extract , the effect of reducing chlorophyll content and increasing alkaloid precipitation rate

Inactive Publication Date: 2020-06-19
安徽恒达药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the "Chinese Pharmacopoeia", there is a relatively clear record of the preparation process of belladonna extract. However, the belladonna extract prepared according to the process in the pharmacopoeia not only has low content of active ingredients, but also has high impurity content and low purity. Reduce the color and shape of the extract, reducing the efficacy of the extract

Method used

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  • Production process for belladonna herb extract

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Effect test

Embodiment 1

[0018] A kind of production technique of belladonna extractum, concrete production technique is as follows:

[0019] 1) Remove impurities, insects, mildew and non-medicinal parts of belladonna, then put 1000kg of belladonna into the processor, add distilled water to submerge the belladonna, and then pressurize the processor to 0.2MPa, and simultaneously feed ozone and distilled water into the processor for 2.5 hours of circulating treatment, wherein the flow rate of distilled water is 12L / min, and the flow rate of ozone is 1L / min. ;

[0020] 2) Put the drained belladonna powder into a coarse powder, then put the belladonna coarse powder into a vacuum treatment tank, inject 3 times the amount of distilled water into the belladonna coarse powder, and first vacuumize to -0.02 MPa, negative pressure treatment 20min, remove vacuum then, pressurize to 0.2MPa, pressurize treatment 40min, repeat processing 2 times, obtain the belladonna coarse powder of saturated state, then use the ...

Embodiment 2

[0027] A kind of production technique of belladonna extractum, concrete production technique is as follows:

[0028] 1) Remove impurities, insects, mildew and non-medicinal parts of belladonna, then put 1000kg of belladonna into the processor, add distilled water to submerge the belladonna, and then pressurize the processor to 0.25MPa, and simultaneously feed ozone and distilled water into the processor for 2 hours of circulation treatment, wherein the flow rate of distilled water is 14L / min, and the flow rate of ozone contained is 1.5L / min. After the treatment is completed, take out the belladonna and drain the water reserve;

[0029] 2) Put the drained belladonna powder into a coarse powder, then put the belladonna coarse powder into a vacuum treatment tank, inject 4 times the amount of distilled water into the belladonna coarse powder, and first vacuumize to -0.05 MPa, negative pressure treatment 15min, remove vacuum then, pressurize to 0.3MPa, pressurize treatment 35min, ...

Embodiment 3

[0036] A kind of production technique of belladonna extractum, concrete production technique is as follows:

[0037] 1) Remove impurities, insects, mildew and non-medicinal parts of belladonna, then put 1000kg of belladonna into the processor, add distilled water to submerge the belladonna, and then pressurize the processor to 0.3MPa, and simultaneously feed ozone and distilled water into the processor for 1.5h circulation, wherein the flow rate of distilled water is 15L / min, and the flow rate of ozone is 2L / min. ;

[0038] 2) Put the drained belladonna powder into a coarse powder, then put the belladonna powder into a vacuum treatment tank, inject 5 times the amount of distilled water into the belladonna powder, and first vacuumize to -0.08 MPa, negative pressure treatment 10min, remove vacuum then, pressurize to 0.5MPa, pressurize treatment 30min, repeat processing 3 times, obtain the belladonna coarse powder of saturated water state, then use the belladonna coarse powder o...

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Abstract

The invention discloses a production process of a belladonna herb extract. The production process comprises the following steps: (1) belladonna herbs are drained off after undergoing ozone cycle treatment; (2) vacuumizing treatment and impregnating treatment are carried out after crushing, and then hydrothermal treatment and microwave treatment are carried out; (3) diacolation is performed; (4) concentration is performed after alcohol recovery, and alcohol is recovered again after alcohol precipitation treatment, and concentration is performed; (5) blending and drying are performed; and (6) crushing and mixing are performed. According to the production process provided by the invention, the belladonna herbs are pretreated before being impregnated, and part of chlorophyll can be removed through ozone cycle treatment, so that the content of the chlorophyll in the extract is reduced, and the purity of the extract is increased; through vacuumizing treatment, coarse powder of the belladonnaherbs is in a water-saturated state; and through hydrothermal treatment and microwave treatment, the alkaloid precipitation rate can be increased during impregnating treatment, and thereby, the yieldof the extract is increased, and the prepared belladonna herb extract has higher purity and better efficacy.

Description

technical field [0001] The invention belongs to the technical field of extracting Chinese herbal medicines, and in particular relates to a production process of belladonna extract. Background technique [0002] Belladonna, alias: wild nightshade, beauty grass, Beladonna grass, solanaceae, belladonna is a perennial herb, or because of cultivation as an annual, the root is thick and cylindrical. The lower part of the stem is single, with purple, the upper part is forked branched, and the shoots are green. It is native to Europe and introduced to China in the 1930s. Belladonna is an infinite growth type. Herbs perennial, or annual due to cultivation. Roots are erect cylindrical. Stem flat hollow cylindrical. The leaves are alternate in the lower part of the stem, with short handles, and the leaves are ovate, ovate-elliptic or elliptic. Like warm and humid climate, afraid of cold, avoid high temperature. It is cultivated in Shandong, Zhejiang and other places in China. Sli...

Claims

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Application Information

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IPC IPC(8): A61K36/81
CPCA61K36/81A61K2236/10A61K2236/13A61K2236/15A61K2236/333A61K2236/51A61K2236/53
Inventor 张涛
Owner 安徽恒达药业有限公司
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