Amino-functionalization gold nanoparticle core-shell structure MOF-5 and preparing method thereof

A MOF-5, amino functionalization technology, applied in nanotechnology, nanotechnology, metal processing equipment, etc., can solve the problem that the photothermal therapy effect of gold nanoparticles cannot be well achieved, the yield of nanoparticles is reduced, and the synthesis steps are cumbersome. and other problems, to achieve the effect of improving yield, improving universality, and good repeatability of preparation

Inactive Publication Date: 2020-06-23
上海燊铭检测技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The synthesis steps are relatively cumbersome, and the increased steps reduce the yield of nanoparticles, and the Au/MOF core-shell structure material produced, the size of gold nanoparticles is

Method used

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  • Amino-functionalization gold nanoparticle core-shell structure MOF-5 and preparing method thereof
  • Amino-functionalization gold nanoparticle core-shell structure MOF-5 and preparing method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0025] A method for preparing amino-functionalized gold nano core-shell structure MOF-5, comprising the steps of:

[0026] (1), prepare the reaction substrate: zinc nitrate hexahydrate Zn(NO 3 ) 2 ·6H 2 O, 2-aminoterephthalic acid (C 8 h 7 NO 4 ), polyvinylpyrrolidone PVP, N,N dimethylformamide mixed with alcohol, chloroauric acid HAuCl 4 Mix according to the mass ratio of 145:30:1820~10920:50000~80000:0.5~8 to obtain the reaction substrate;

[0027] (2), the obtained reaction substrate is fully dissolved in the reaction vessel to form a transparent, uniform and stable liquid;

[0028] (3), take out a certain amount of said liquid, join in hydrothermal kettle or other container that can carry out solvothermal reaction;

[0029] (4), the above-mentioned liquid is reacted at a temperature of 100-150° C. for 1-48 hours;

[0030] (5), after the reaction is finished, cool to room temperature, centrifuge at a certain speed to obtain the gold nano core-shell structure MOF-5 c...

Embodiment 2

[0033] A method for preparing amino-functionalized gold nano core-shell structure MOF-5, comprising the steps of:

[0034] (1), prepare the reaction substrate: zinc nitrate hexahydrate Zn(NO 3 ) 2 ·6H 2 O, 2-aminoterephthalic acid (C 8 h 7 NO 4 ), polyvinylpyrrolidone PVP, N, N dimethylformamide mixed with alcohol, chloroauric acid HAuCl 4 The reaction substrate is obtained by mixing according to the mass ratio of 145:30:4800-9600:60000-80000:0.5-8; polyvinylpyrrolidone PVP is preferably 7280.

[0035] (2), the obtained reaction substrate is fully dissolved in the reaction vessel to form a transparent, uniform and stable liquid;

[0036] (3), take out a certain amount of said liquid, join in hydrothermal kettle or other container that can carry out solvothermal reaction;

[0037] (4) The above liquid was reacted for 3 hours at a temperature of 140°C;

[0038] (5), after the reaction finishes, cool naturally to room temperature, centrifuge with the rotating speed of 250...

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Abstract

According to the invention, a one-step method is adopted, based on solvothermal synthesis, polyvinylpyrrolidone (PVP), zinc nitrate hexahydrate (Zn(NO3)2.6H2O), 2-aminoterephthalic acid (C8H7NO4), anN,N-dimethylformamide/alcohol mixed solvent and chloroauric acid HAuCl4 are blended and loaded in a hydrothermal kettle for making a reaction, a metal organic frame structure is formed, and meanwhile,a gold nanoparticle core is formed through decomposition of the chloroauric acid under the high temperature condition; and meanwhile, micelle formed by the PVP is used, growth of the MOF-5 structureis limited, so that the MOF-5 composite material which has monodispersity, is uniform in particle size and is of the gold nanoparticle core-shell structure is prepared.

Description

Technical field: [0001] The present application belongs to the technical field of nanomaterial preparation, in particular, it belongs to a method for preparing amino-functionalized gold nano-core-shell structure MOF-5. Background technique: [0002] Gold nanoparticles have unique, size-dependent properties in optical, thermal, electrical, magnetic, and chemical aspects, such as surface plasmon resonance absorption (SPR), Raman scattering (RS), catalytic activity, and biocompatibility , Higher X-ray absorption coefficient. Functionalized gold nanoparticles (Au-core-shell structure) have good biocompatibility, water solubility and stability, and can be metabolized and excreted in the body. They are very potential CT contrast agents / photoacoustic imaging diagnostic reagents. Nanogold can also be used for photothermal therapy, and as a transportation platform to load other diagnostic and therapeutic reagents. In scientific research and clinical practice, it can realize the diag...

Claims

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Application Information

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IPC IPC(8): B22F1/02B22F9/24B22F1/00B82Y30/00B82Y40/00
CPCB22F9/24B82Y30/00B82Y40/00B22F1/07B22F1/16B22F1/054
Inventor 秦湘奇杨盛兵黄凯
Owner 上海燊铭检测技术有限公司
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