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Pharmaceutical composition for preventing or treating glioma

A composition and technology for glioma, applied in the field of chemotherapy for glioma, can solve the problems of limited effect and few targeted drugs

Active Publication Date: 2020-06-30
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, breakthroughs have been made in targeted therapy for lung cancer, leukemia, breast cancer, and colorectal cancer, but there are only a handful of targeted drugs that can be used for HGG, and the effect is very limited

Method used

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  • Pharmaceutical composition for preventing or treating glioma
  • Pharmaceutical composition for preventing or treating glioma
  • Pharmaceutical composition for preventing or treating glioma

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0075] 1. R406 can efficiently inhibit the cell viability and cell proliferation of glioma stem cells

[0076] Experimental Materials

[0077] Glioma stem cell lines GSC-1 and GSC-2 (isolated and cultured from neurosurgery tumor tissue specimens of Sun Yat-sen University Cancer Center). R406 (free base) 50mg freeze-dried powder, made into 40mM stock solution with DMSO, diluted with DMSO to 10mM stock solution as needed, filtered, and stored at -20°C. Medium preparation: 500ml DMEM / F12+2%B27+20ng / ml bFGF+20ng / mlEGF+50U / ml penicillin+50μg / ml streptomycin. The C17.2 mouse neural stem cell line was generously provided by Pi Rongbiao, Professor of Pharmacology, Zhongshan School of Medicine, Sun Yat-sen University. C17.2 cells were routinely cultured in DMEM supplemented with 10% FBS (Gibco), 5% horse serum (Gibco) and 2 mM L-glutamine.

[0078] experimental method

[0079] Cultivation of glioma stem cells: Glioma stem cell lines are cultured in a well-prepared DMEM / F12 medium...

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PUM

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Abstract

The invention provides a pharmaceutical composition for treating glioma. The pharmaceutical composition comprises a therapeutically effective amount of Tamatinib or prodrugs or pharmaceutical salts ofTamatinib and a therapeutically effective amount of temozolomide or prodrugs or pharmaceutical salts of temozolomide. The invention also provides a pill case for treating glioma, wherein the pill case comprises a first pharmaceutical composition body and a second pharmaceutical composition body, the first pharmaceutical composition body comprises a therapeutically effective amount of Tamatinib orprodrugs or pharmaceutical salts of Tamatinib, and the second pharmaceutical composition body contains a therapeutically effective amount of temozolomide or prodrugs or pharmaceutical salts of temozolomide. The invention further provides application of Tamatinib or prodrugs or pharmaceutical salts of Tamatinib as sensitizers in chemotherapy drugs for treatment of glioma.

Description

technical field [0001] The present invention relates to chemotherapy for glioma, in particular to a pharmaceutical composition for preventing or treating glioma. The present invention also relates to the use of the pharmaceutical composition in treating glioma with glioma stem cells and preventing or treating recurrence of glioma. Background technique [0002] According to the molecular pathological characteristics and biological behavior of tumors, gliomas can be divided into WHO grades I to IV from low to high malignancy, of which WHO grade III and WHO grade IV gliomas are collectively referred to as high-grade gliomas (High-grade gliomas). -grade Glioma, HGG), including anaplastic astrocytoma, anaplastic oligodendroglioma, and the most malignant glioblastoma (Glioblastoma, GBM). HGG is the most common invasive intracranial primary tumor. It is often combined with surgery, radiotherapy and chemotherapy for comprehensive treatment in clinical practice, but the treatment ef...

Claims

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Application Information

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IPC IPC(8): A61K31/5383A61K31/675A61K31/4188A61P35/00
CPCA61K31/5383A61K31/675A61K31/4188A61P35/00A61K2300/00
Inventor 朱文博赛克孙叔昕刘文锋陈智杰蒋小兵张继
Owner SUN YAT SEN UNIV
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