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Production method of virus-inactivated plasma for treating COVID-19

A COVID-19, plasma technology, applied in the field of medicine, can solve the problems of missed detection during the detection technology window period, and achieve the effect of reducing mortality and improving cure rate

Inactive Publication Date: 2020-06-30
国药集团武汉血液制品有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main risks are: due to the limitations of the current detection of pathogen types, the detection technology has the limitation of missed detection during the window period, etc.

Method used

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  • Production method of virus-inactivated plasma for treating COVID-19
  • Production method of virus-inactivated plasma for treating COVID-19
  • Production method of virus-inactivated plasma for treating COVID-19

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Example 1. Plasma collection of convalescent patients with COVID-19

[0023] 1. Plasma collection standards,

[0024] Rehabilitation patients who donate plasma should meet the following conditions at the same time:

[0025] ①The recovery from the new crown is not less than 3 weeks from the first symptom;

[0026] ②Recovered patients meet the criteria for release from isolation and discharge in the latest version of the COVID-19 diagnosis and treatment plan issued by the National Health and Medical Commission;

[0027] ③The age should be at least 18 years old and not more than 55 years old;

[0028] ④The weight of men is not less than 50 kg, and that of women is not less than 45 kg;

[0029] ⑤ No history of menstrual blood-borne diseases;

[0030] ⑥Those who can donate plasma after comprehensive patient treatment and other related evaluation by clinicians.

[0031] 2. Collection steps:

[0032] After signing the informed consent form, plasma collection is performed...

Embodiment 2

[0042] Embodiment 2, the operation process of methylene blue inactivated plasma

[0043] This method requires aseptic technique throughout.

[0044] 1. Add methylene blue to the raw material plasma: the plasma flows through the methylene blue (MB) adding element, flows into the light bag, and the methylene blue content in the blood plasma flowing into the light bag is 0.9-2.6 μmol / L, preferably 0.9-1.3 μmol / L.

[0045] 2. After the addition of methylene blue, heat seal (seal by heating) the plasma inlet tube, put the plasma-containing light bag and the adsorption filter component connected to it into the medical plasma virus inactivation cabinet, and light inactivate it. The light intensity is 30000-40000lx (30W fluorescent lamp, wavelength 600-700nm), the swing range is 50mm±10mm, the swing frequency is 60 times / minute±5 times / minute, and the effective light time is not less than 30min.

[0046]3. After the light inactivation is completed, place the light bag at a high pla...

Embodiment 3

[0050] Embodiment 3, inactivated plasma preparation example 1

[0051] 1. Melt 3 bags of plasma from patients who have recovered from COVID-19, and follow the steps below for each bag of plasma;

[0052] 2. Add methylene blue (MB): Flow a small amount of plasma through the "MB adding element", and then close the stop clamp. When the plasma stays in the MB adding element for about 1-2 minutes, the sub The content of formazan blue is 0.9-1.3μmol / L, and then open the stop clip to make the plasma completely flow into the light bag;

[0053] 2. After the addition of methylene blue, heat-seal the inlet tube, put the plasma-containing light bag and adsorption filter parts into the medical plasma virus inactivation cabinet, and light inactivate the plasma virus. The light intensity is 30000-40000lx, the swing range is 50mm±10mm, the swing frequency is 60 times / minute±5 times / minute, and the effective light time is 30min;

[0054] 3. After the light inactivation is completed, place t...

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Abstract

The invention relates to a production method of virus-inactivated plasma for treating COVID-19. The method comprises the following steps: (1) collecting convalescent plasma of COVID-19 survivors or plasma immune to a Severe Acute Respiratory Syndrome Coronavirus 2 vaccine (SARS-CoV-2 vaccine), and conducting pretreatment; (2) adding methylene blue, and conducting photo-inactivation on the plasma;and (3) conducting labeling and packaging after the plasma passes tests.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a method for preparing virus-inactivated plasma for treating COVID-19. Background technique [0002] Novel coronavirus disease 2019 (COVID-19) is an acute infectious disease caused by severe acute respiratory syndrome coronavirus 2 (Severe Acute Respiratory Syndrome Coronavirus 2, SARS-CoV-2). SARS-CoV-2 is a single-stranded positive-strand RNA virus with an envelope. It is a coronavirus belonging to the genus Beta of the Coronaviridae family. It is the seventh member of the coronavirus family currently infecting humans. It is mainly transmitted through respiratory droplets and close contact. It may also be transmitted through aerosol and digestive tract fecal-oral routes. The clinical manifestations of COVID-19 are fever, dry cough, and fatigue. Some patients may develop symptoms such as dyspnea and diarrhea, which may progress to symptoms such as acute respiratory...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/16A61P31/14
CPCA61K35/16A61P31/14
Inventor 杨晓明李策生段凯何彦林胡勇彭焱周志军林连珍喻剑虹韩韧梁小龙邢延涛侯勇芦忠泉邓琨王月龚钦郑宵蓓刘莹朱晨邓志军邹浩勇贾玲刘智鹏刘春杰司世宏潘晓明冯璐詹骞陈克金李陶敬岳胜兰吴晓谢勇余鼎周东波杨汇川
Owner 国药集团武汉血液制品有限公司
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