Thin-layer tissue blood oxygen imaging method and device based on Lambert-Beer's law

An imaging method and tissue image technology, applied in the field of biomedicine, can solve problems such as inability to apply to skin surface or tissue blood oxygen saturation, high misjudgment rate, etc., achieving high real-time performance, high accuracy, and avoiding blood contamination effects.

Active Publication Date: 2021-05-28
HENAN UNIVERSITY
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Problems solved by technology

[0004] In order to solve the problems of high misjudgment rate in the traditional method of distinguishing ureters and blood vessels based on experience and the existing blood oxygen saturation detection algorithm cannot be applied to the blood oxygen saturation of the skin surface or tissue, the present invention provides a Lambert-based Thin-layer tissue blood oxygen imaging method and device based on Beer's law, the present invention measures the two-dimensional light intensity distribution at different wavelengths according to the different absorption intensities of blood and other components to light of different wavelengths, thereby obtaining the blood oxygen saturation Two-dimensional distribution, and then achieve the function of vascular urinary catheter identification

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  • Thin-layer tissue blood oxygen imaging method and device based on Lambert-Beer's law

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Embodiment 1

[0039] Such as figure 1 As shown, the embodiment of the present invention provides a thin-layer tissue blood oxygen imaging method based on Lambert-Beer's law, the method includes the following steps:

[0040] S101. Control the light source to sequentially emit the first wavelength λ 1 light, the second wavelength λ 2 light and the third wavelength λ3 the light;

[0041] S102. Collecting data at the first wavelength λ respectively 1 light, the second wavelength λ 2 light and the third wavelength λ 3 The images of the thin-layer tissue to be measured under the irradiation of the light are sequentially recorded as the first thin-layer tissue image, the second thin-layer tissue image and the third thin-layer tissue image;

[0042] S103. According to the first thin-layer tissue image, the second thin-layer tissue image, and the third thin-layer tissue image, calculate and obtain the blood oxygen distribution of the thin-layer tissue to be measured by using a preset blood oxyg...

Embodiment approach

[0076] As a possible implementation, the experimental calibration method is specifically:

[0077] In the air, an n*n detector array is fixed at a preset position away from the light source, and the first wavelength λ is measured by the detector array 1 The two-dimensional light intensity distribution of Second wavelength λ 2 The two-dimensional light intensity distribution of the light is third wavelength λ 3 The two-dimensional light intensity distribution of the light is then there is In order to ensure the accuracy of detection, the larger the value of n, the better the accuracy, for example, it can be set as a 10*10 detector array.

[0078] Since the blood oxygen saturation value is between 0 and 1, as a possible implementation, the above step S104 is specifically: mapping the blood oxygen distribution of the thin-layer tissue to be measured between 0 and 255 to form a gray scale Figure to display.

Embodiment 2

[0080] Correspondingly, an embodiment of the present invention also provides a thin-layer tissue blood oxygen imaging device based on Lambert-Beer's law, which is used to implement the above method. The device includes: a control unit 201 , an image acquisition unit 202 , a blood oxygen distribution calculation unit 203 and a display unit 204 . in:

[0081] The control unit 201 is used to control the light source to sequentially emit the first wavelength λ 1 light, the second wavelength λ 2 light and the third wavelength λ 3 light; the image acquisition unit 202 is used to collect the light at the first wavelength λ respectively 1 light, the second wavelength λ 2 light and the third wavelength λ 3 The images of the thin-layer tissue to be measured under the irradiation of light are sequentially recorded as the first thin-layer tissue image, the second thin-layer tissue image and the third thin-layer tissue image; the blood oxygen distribution calculation unit 203 is used ...

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Abstract

The invention provides a thin-layer tissue blood oxygen imaging method and device based on Lambert-Beer's law. The method includes: controlling the light source to sequentially emit the first wavelength λ 1 light, the second wavelength λ 2 light and the third wavelength λ 3 light; respectively collected at the first wavelength λ 1 light, the second wavelength λ 2 light and the third wavelength λ 3 The images of the thin-layer tissue to be measured under the irradiation of light are sequentially recorded as the first thin-layer tissue image, the second thin-layer tissue image and the third thin-layer tissue image; according to the first thin-layer tissue image, the second thin-layer tissue image For the tissue image and the third thin-layer tissue image, the blood oxygen distribution of the thin-layer tissue to be measured is calculated by using the preset blood oxygen distribution algorithm; the blood oxygen distribution of the thin-layer tissue to be measured is converted to the image domain for display. According to the difference in absorption intensity of different wavelengths of light by blood and other components, the present invention obtains the two-dimensional distribution of blood oxygen saturation by measuring the two-dimensional light intensity distribution at different wavelengths, and then achieves the function of identifying blood vessels and urinary catheters.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a thin-layer tissue blood oxygen imaging method and device based on Lambert-Beer's law. Background technique [0002] In clinical surgery, especially in abdominal or pelvic surgery, it is usually necessary to operate on the blood vessels in the operation, but because the surface of the ureter and blood vessels are covered with tissue components such as fat, the tissue adhesion is relatively heavy, so the surgeon cannot dissect the ureter normally , the relationship between blood vessels and surrounding tissues, it may also be due to various reasons such as insufficient experience of the surgeon, lack of familiarity with the direction of normal ureters and blood vessels, etc., which may cause accidental injury or even necrosis of the ureter. Once the ureter is damaged, it will cause various complications. , such as genitourinary fistula formation, hydronephrosis, renal functio...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61B5/1455A61B5/145G06T7/00
CPCA61B5/14542A61B5/14551G06T7/0012G06T2207/10141G06T2207/30101
Inventor 张锦龙张峰尤贺贺静樊琳琳
Owner HENAN UNIVERSITY
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