Thermo-chromic micro-capsule and preparation method and application thereof

A technology of thermochromic and color developer

Inactive Publication Date: 2020-07-10
JIANGSU UNIV
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no anti-tumor thermochromic microcapsule that can change the light penetration effect.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Thermo-chromic micro-capsule and preparation method and application thereof
  • Thermo-chromic micro-capsule and preparation method and application thereof
  • Thermo-chromic micro-capsule and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Embodiment 1: Preparation of thermochromic microcapsules

[0033] In this example, thermochromic microcapsules were prepared by the following steps:

[0034] Mix 20 mg of thermal black TF-BL3 (purchased from Changshu Jiayou Machinery Equipment Co., Ltd.), 100 mg of 2-naphthol and 1200 mg of cetyl alcohol to a molten state, and then disperse them in 10 mL of gum arabic aqueous solution ( 4.5%), mixed evenly in a tissue masher after a little stirring, and quickly emulsified for 15 seconds; the emulsified colostrum was transferred to a 100 mL beaker and placed in a 60°C water bath, and 10 mL of Type A gelatin aqueous solution (4.5%) to obtain a uniform mixed solution;

[0035] Add 10% acetic acid (HAc) dropwise under stirring to adjust the pH of the mixture to 3.8, add 20 mL of distilled water at 40°C while stirring, add about 0.24 mL of formaldehyde solution to cross-link and solidify, and stir for 10 minutes; use 20% NaOH to adjust the pH to 7 , after stirring and mixi...

Embodiment 2

[0036] Embodiment 2: Preparation of thermochromic microcapsules

[0037] In this example, thermochromic microcapsules were prepared by the following steps:

[0038] Mix 20 mg thermal black TF-BL1 (purchased from Changshu Jiayou Machinery Equipment Co., Ltd.), 160 mg 1-naphthol and 1920 mg cetyl alcohol, heat to melt, and disperse in 16 mL aqueous gum arabic solution (5% ) and mix evenly in a tissue masher for 15 seconds after a little stirring; transfer the emulsified colostrum into a beaker and place it in a water bath at 60°C, and add 16 mL of type A gelatin aqueous solution to it while stirring (5%) to get a homogeneous mixture;

[0039] Add 10% acetic acid (HAc) dropwise under stirring to adjust the pH of the mixture to 3.9, add 32 mL of distilled water at 40°C while stirring, add about 0.384 mL of formaldehyde solution to cross-link and solidify, and stir for 10 minutes; use 20% NaOH to adjust the pH to 7.5 , after stirring and mixing, the thermochromic microcapsules we...

Embodiment 3

[0040] Embodiment 3: Preparation of thermochromic microcapsules

[0041] In this example, thermochromic microcapsules were prepared by the following steps:

[0042] Mix 20 mg of thermosensitive green (TF-G) and 200 mg of bisphenol A (BPA) with 2400 mg of cetyl alcohol and heat to a molten state, then disperse in 20 mL of gum arabic aqueous solution (6%) and mix well, After a little stirring, it was placed in a tissue masher for rapid emulsification for 5 seconds; the emulsified colostrum was transferred to a beaker and placed in a 62°C water bath, and 20 mL of type A gelatin aqueous solution (6%) was added to it while stirring. well mixed;

[0043] Add 10% HAc dropwise under stirring to adjust the pH of the mixture to 4.0, add 40 mL of distilled water at 42°C under constant stirring, add about 0.48 mL of formaldehyde solution, and stir for 10 minutes; use 20% NaOH to adjust the pH to 8.0, stir for 10 minutes, and heat The color-changing microcapsules were prepared successful...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention belongs to the technical field of biological materials and particularly relates to a thermo-chromic micro-capsule and a preparation method and application thereof. The thermo-chromic micro-capsule provided by the invention is wrapped with a leuco dye and a color developing agent, has complete thermal metachrosis and deeper tumor penetrating power, and can be applied to deep photo-thermal ablation of tumors as a photo-thermal agent. The leuco dye and the color developing agent are wrapped inside a capsule material constituted of Arabic gum and Type A gelatin by a complex coacervation method, a preparation course is simple, cost is low and bio-toxicity is low, and biological safety is high. The prepared thermo-chromic micro-capsule displays a color under a constant temperaturestate, the thermo-chromic micro-capsule absorbs near-infrared light and converts the light into thermal energy after being irradiated by the near-infrared light, and then the thermo-chromic micro-capsule turns to a colorless state with certain transparency. Deep tumor killing effects are enhanced, and the thermo-chromic micro-capsule has wide application prospect in the field of photo-thermal resistance to tumors.

Description

technical field [0001] The invention belongs to the technical field of biological materials, and in particular relates to a thermochromic microcapsule and its preparation method and application. Background technique [0002] Tumor is a major public problem that seriously threatens the health of the public. Death due to cancer has become an important cause of death among residents in my country. Due to the aging population trend, the number of cancer patients in my country will increase in the future, so the treatment of tumors is particularly important. Compared with traditional chemotherapy, surgery and other methods, photothermal anti-tumor therapy is a promising cancer treatment method due to its minimal invasiveness and clear therapeutic effect. With the help of light-absorbing materials, light energy can be effectively converted into heat energy, and then kill tumor cells. However, the penetration depth of laser light during the treatment of existing photothermal therap...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K9/50A61K47/10A61K47/12A61K41/00A61P35/00
CPCA61K9/5015A61K41/0052A61P35/00
Inventor 沈松冯磊戈延茹戚雪勇吴琳
Owner JIANGSU UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap