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Active silver ion colloid antibacterial agent and preparation method thereof

A technology of silver ions and antibacterial agents, which is applied in the field of medical and surgical medicine, can solve the problems of harsh processing conditions, irritating taste, and no permeability, and achieves the effects of shortening healing time, no side effects, and no peculiar smell, and shortening the treatment cycle.

Inactive Publication Date: 2020-07-14
盐城市汇信复康生物科技发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among the above three patented technical solutions, the first two belong to the category of non-medical clinical disinfectant solution, which is used for disinfection and sterilization of utensils such as tableware and bathware in people's daily life, as well as cleaning and sterilization of skin (CN1262101A) , not suitable for infection control such as burns, scalds, open wounds and wounds on the human body surface
And the third document (CN1110557A) belongs to traumatic treatment and has curative effect in surgical medicine and has occupied the pivotal position always, inferior then is to cause patient's local or systemic anaphylaxis frequent, drug-resistant bacterial strain increases day by day, has irritating smell, is harmful to human body. Inhibition of epidermal cell growth, adverse effects on renal function
However, this patented technical solution also has deficiencies. First, the treatment effect on the deep part of the wound is not ideal, because it is as impermeable as sulfadiazine silver cream; secondly, the formula has many raw materials; the processing conditions introduced are harsh

Method used

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  • Active silver ion colloid antibacterial agent and preparation method thereof
  • Active silver ion colloid antibacterial agent and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] A) Add commercially available active silver ion powders such as those produced and sold by Sinopharm Chemical Reagent Co., Ltd. into deionized water with a purity of 0.1-0.16 μs / cm measured by a conductivity meter and stir evenly. The container used can either be a polyethylene plastic container or a stainless steel container, until the active silver ion powder is fully dissolved, thereby obtaining the active silver ion powder body liquid;

[0023] B) adding reagent-grade phosphoric acid to the active silver ion powder liquid obtained in step A) to carry out acidification treatment, the time of acidification treatment is 30min, adjust PH2, and obtain the active silver ion powder mixed liquid after acidification treatment;

[0024] C) adding commercially available reagent-grade tartaric acid, such as produced and sold by China Shanghai Reagent No. 1 Factory, into deionized water with the same purity of 0.1-0.16 μs / cm and stirring for 20 minutes to obtain a tartaric acid s...

Embodiment 2

[0030] A) Add commercially available active silver ion powders such as those produced and sold by Sinopharm Chemical Reagent Co., Ltd. into distilled water with a purity of 0.1-0.16 μs / cm measured by a conductivity meter and stir evenly. The container can be a polyethylene plastic container or a stainless steel container until the active silver ion powder is fully dissolved, thereby obtaining the active silver ion powder body liquid;

[0031] B) adding reagent-grade phosphoric acid to the active silver ion powder body liquid obtained in step A) for acidification treatment, the time of acidification treatment is 18min, adjust PH1.8, and obtain the active silver ion powder mixed liquid after acidification treatment ;

[0032] C) adding commercially available reagent-grade tartaric acid, such as produced and sold by China Shanghai Reagent No. 1 Factory, into distilled water with the same purity of 0.1-0.16 μs / cm and stirring for 35 minutes to obtain a tartaric acid solution;

[...

Embodiment 3

[0037] A) Add commercially available active silver ion powders such as those produced and sold by Sinopharm Chemical Reagent Co., Ltd. into deionized water with a purity of 0.1-0.16 μs / cm measured by a conductivity meter and stir evenly. The container used can either be a polyethylene plastic container or a stainless steel container, until the active silver ion powder is fully dissolved, thereby obtaining the active silver ion powder body liquid;

[0038] B) adding reagent-grade citric acid to the active silver ion powder body liquid obtained in step A) for acidification treatment, the time of acidification treatment is 35min, adjust the pH to 1.5, and obtain the mixed active silver ion powder after acidification treatment liquid.

[0039]C) adding commercially available reagent-grade tartaric acid, such as produced and sold by China Shanghai Reagent No. 1 Factory, into deionized water with the same purity of 0.1-0.16 μs / cm and stirring for 15 minutes to obtain a tartaric acid...

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Abstract

The invention relates to an active silver ion colloid antibacterial agent applicable to infection control and wound heal promotion for human body surfaces, also relates to a preparation method of theactive silver ion colloid antibacterial agent, and belongs to the technical field of medicines for medical surgery. A finished liquid agent formed by the active silver ion colloid antibacterial agentcontains active silver ion powder, sodium alginate, dibasic acid, a penetrant, tartaric acid and purified water. The active silver ion colloid antibacterial agent and the preparation method thereof have the following advantages: firstly, a stabilizer with a permeation effect is adopted in a formula, can permeate through deep tissue of a wound, kill bacteria and endotoxins in deep parts and loosen,resolve and discharge necrotic tissue, pus and blood clots out of the body and contributes to shortening the wound heal time; secondly, the active silver ion colloid antibacterial agent does not cause obvious drug membranes or produce drug resistance by long-term use and can effectively shorten the treatment period; thirdly, the active silver ion colloid antibacterial agent causes no side effectson a patient and has no foreign smells or sensitization; and fourthly, the method comprises few process steps, has no harsh conditions and can adapt to mass production requirements.

Description

technical field [0001] The invention relates to an active silver ion colloidal antibacterial agent, which is suitable for controlling infection of human body surface wounds and promoting wound healing, and also relates to a preparation method of the active silver ion colloidal antibacterial agent, which belongs to the technical field of medical surgical medication. Background technique [0002] At present, the medicines for wound infection caused by burns, scalds, and open wounds are mainly sulfadiazine silver cream (also known as ointment) or suspension, and its active ingredients are mainly sulfadiazine except sulfadiazine. It is silver nitrate, which is widely used clinically. However, there are still the following deficiencies in clinical application: First, because this drug is not permeable, it is difficult to effectively kill the bacteria in the deep part of the wound, and it is easy to form an obvious drug film on the surface, resulting in a longer healing time of th...

Claims

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Application Information

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IPC IPC(8): A61K33/38A61K9/70A61K47/04A61P17/02A61P31/04
CPCA61K9/7007A61K33/38A61K47/02A61P17/02A61P31/04
Inventor 汪健
Owner 盐城市汇信复康生物科技发展有限公司
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