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Steviolbioside crystal with crystal form B, preparation method and application thereof

A technology of steviobioside and crystal form, which is applied in the field of sweeteners, can solve problems such as the instability of stevioside crystal form A, and achieve the effects of good water solubility, easy operation and high stability

Inactive Publication Date: 2020-07-14
DONGTAI HIRYE BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The technical problem to be solved by the present invention is that the existing crystal form A of stevioside is unstable under high humidity conditions

Method used

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  • Steviolbioside crystal with crystal form B, preparation method and application thereof
  • Steviolbioside crystal with crystal form B, preparation method and application thereof
  • Steviolbioside crystal with crystal form B, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Mix 8 g of steviol diglycoside with a dry matter purity of 80% with 100 mL of water (boiling point 100°C), stir at 30 rpm at 80°C for 0.3h, and cool the above solution to 30°C to obtain a steviol diglycoside suspension A; Suspension A was stirred at 65°C and 30 rpm for 2 hours, cooled to 10°C, and a solid was precipitated. After drying the solid at 100°C, the steviol diglycoside crystals with crystal form B were obtained. There are no obvious endothermic and exothermic peaks in the characteristic curve in the differential scanning thermal analysis chart of the product.

Embodiment 2

[0035] Mix 20 g of steviol diglycoside with a dry matter purity of 99.5% and 100 mL of a methanol aqueous solution with a volume concentration of 90% (boiling point 91.8°C), stir at 30°C at 10 rpm for 1 h, and cool to 25°C to obtain a steviol diglycoside suspension A ; Suspension A was stirred at 15° C., 10 rpm for 2 hours, cooled to 5° C., and a solid was precipitated. After the solid was dried in vacuum at 25° C., the steviol diglycoside crystals with crystal form B were obtained.

Embodiment 3

[0037] Mix 30 g of steviol diglycoside with a dry matter purity of 55% and 100 mL of an aqueous solution of 97% isopropanol (boiling point 80.4°C) with a volume concentration, and stir at 40°C at 20 rpm for 1 hour. Cool the above solution to 10°C to obtain stevia Suspension A of Diglycoside; Stir Suspension A at 25°C and 10rpm for 4h, cool to 5°C, and precipitate a solid. The solid obtained after filtration is dried under vacuum at 45°C to obtain a Stevia double with crystal form B Glycoside crystals.

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Abstract

The invention discloses a steviolbioside crystal with a crystal form B, a preparation method and application thereof, and belongs to the technical field of sweeteners. The steviolbioside crystal has distinct characteristic diffraction peaks expressed in degrees at 2theta angles of at least 4.84, 7.32, 8.60, 16.02 and 17.14 using X-ray powder diffraction analysis measured using Cu-Kalpha radiation.The crystal is characterized by solid chemical analysis means such as XRD, DSC, TGA and the like, and the crystal is found to have advantages of good water solubility, high stability and the like, and is suitable for a wider application field. The preparation method is simple, easy to operate, multiple in selectivity and good in reproducibility, and can stably obtain the target crystal form.

Description

Technical field [0001] The invention belongs to the technical field of sweeteners, and in particular relates to a steviol diglycoside crystal with crystal form B, a preparation method and application. Background technique [0002] Steviol glycoside is a natural non-nutritive sweetener, containing stevioside, rebaudioside AF, steviol diglycoside and other ingredients. They are all tetracyclic diterpene compounds, but each glycoside has its own unique The taste characteristics and sweetness. In recent years, with the broadening of the application field of steviol glycosides, industry has put forward new requirements for the properties of steviol glycosides such as water solubility and stability. Steviol A glycosides, which are rich in steviol glycosides, have good taste and wide application. Its crystal form 7 and crystal form 9 have been reported by patent CN103739639A and patent CN103739640A respectively. Good solubility, high stability and high crystallinity make the two The s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H15/256C07H1/06A23L2/60A23L27/30A23L29/30
CPCA23L2/60A23L27/36A23L29/30C07B2200/13C07H15/256
Inventor 夏咏梅张童童李磊方云沈洁樊晔胡学一
Owner DONGTAI HIRYE BIOTECH CO LTD